DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and sema3e

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001038549.1	Gene:	sema3e / 565658	ZFINID:	ZDB-GENE-030131-7864	Length:	768	Species:	Danio rerio

Alignment Length:	722	Identity:	196/722 - (27%)
Similarity:	326/722 - (45%)	Gaps:	129/722 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFD 128
            |:|...|..::|.::.|.:|..|.::.:||:.|::.:..   |....:::.|..|:.:|:.:. :
Zfish    51 GRLQQYTMLLDETQERLIIGGKDVLYSLNLERITAPHKR---IVWSSSQEQVEDCLMQGREKP-E 111

  Fly   129 CKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVI---GVGLGIAKCPYDPLDN 190
            |.|:::::|..: ...|..|||.|.:|....|..:.......|:.:   .:..|..:.|:.| ::
Zfish   112 CANYIKLVQHYN-STHLLACGTGAFSPVCAYIRVSRGAEQEREFRLESDHIESGRGRVPFHP-NS 174

  Fly   191 STAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNF 255
            ..|..|..|.      |:.|...::.:.|..::|..         .:.|.||...|.:.|::|.|
Zfish   175 PLASTVYRGE------LFVGLYTDYWENDAALYRLG---------NHSFIRTEVGDRQQLNEPKF 224

  Fly   256 VGSFDI-------GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARL 313
            |||..|       .:.||:||.|...:.....||||:|:||||..|.||:.:|.:.|:::||.||
Zfish   225 VGSAVIPDNDDPADDKVYYFFTERVADVEGGNKAVYTRVARVCANDQGGQRMLVNRWSSFLKTRL 289

  Fly   314 NCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKF 373
            .||::|.  ...:|:|::.|:.|.....:   .|..|:|::....|.|||.:::::|:|||||.|
Zfish   290 ICSVAGPNGIDTHFDELEDVFVLRKKDEKNPEIFGLFSTTSAVFKGYAVCMYNMDDIRAAFNGPF 354

  Fly   374 KEQSSSNSAWLPVLNSRVPEPRPGTCV--------NDTSNLPDTVLNFIRSHPLMDKAVNHEHNN 430
            ..:..::..| .|.:.:||.||||:|.        :.:....|.||.|.||||||.:||...|..
Zfish   355 AHRERTDHHW-KVYDGKVPYPRPGSCASKINGGHFSSSKEYSDEVLRFARSHPLMFQAVQPVHRR 418

  Fly   431 PVYYKRD--LVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRN-----GESLSKLLDI 488
            |:....:  ...|:|.||  |::..:..|.|.::||:...:.|::..|..     .|.|.:.|.:
Zfish   419 PILLDTEGGRKLTQLAVD--RVEAEDGHYNVLFIGTDNSVVLKMITIYNKEADTVEEVLLEELQV 481

  Fly   489 FEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTC- 550
            |:| |....::: ||..|:.||:|::..:.||.:..|......|..|  .|||||.||  ..||
Zfish   482 FKV-PVPITEIL-ISTKRQQLYVGSELGVTQIRVHQCGLYGSACADCCLARDPYCAWD--GFTCS 542

  Fly   551 RPYELDLL-------QDVANETS-------DICDSSVLKKKIVVTYG---QSVHLGCFVKIPEVL 598
            |.|...|.       |||.:..:       .:.:...:.:|:|  ||   .|..|.|   .|..|
Zfish   543 RYYPAGLYTKRRFRRQDVRHGNAVQQCNGLQLSEEQSISEKLV--YGVENNSTLLEC---RPRSL 602

  Fly   599 KNEQVTWY-HHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC----HLGGSLLCSYN 658
            : ..|||| .|..|  ..|:: |..:.|: |..||:::.:.::|.|.|.|    |  |.:.....
Zfish   603 Q-ASVTWYIEHGLD--MEEVK-SDDRMIQ-TPHGLLLLRIMKSDAGVYVCQSTEH--GFIQTLLR 660

  Fly   659 ITVDA---------------------HRCTPPNKSNDYQKIYSDWCHEFEKYKTAMKSWEKKQAQ 702
            :|::.                     ||..||             |.......|:.|.|.|...|
Zfish   661 VTLEVLEEGKVEALLHKPEEEDSDLPHRAAPP-------------CSFPSLPSTSSKLWYKDFMQ 712

  Fly   703 CSTRQNF 709
            .....||
Zfish   713 LIGYSNF 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	137/486 (28%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	28/119 (24%)
sema3e	NP_001038549.1	Sema_3E	46..516	CDD:200514	138/490 (28%)
		PSI	515..563	CDD:214655	18/49 (37%)
		Ig_Semaphorin_classIII	580..668	CDD:143279	28/99 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9670
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910