Protein Alignment Sema2a and sema4c

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001121718.1
• Gene: sema4c / 561895
• ZFINID: ZDB-GENE-080303-16
• Length: 863
• Species: Danio rerio
• Alignment Length: 647
• Identity: 190/647 - (29%)
• Similarity: 284/647 - (43%)
• Gaps: 102/647 - (15%)

  Fly    56 DHVREFNC-GKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCV 119
            |.:..|.. |...|....:.|....|||||.:.:|.::..:||..  .|..|......:....|.
Zfish    38 DSMARFRAVGVWNYTMLTLAEHERVLYVGARENIFALDPNDISRQ--LRPQIEWSAPAEKKKECA 100

  Fly   120 SKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCP 184
            :|||:...:|.|::|.:||.:. ..||.|||.|..||  ..|.|..|.......:..|.|  |||
Zfish   101 AKGKNNQTECFNYIRFLQSYNH-THLYTCGTYAFQPK--CTYINADHFTLDSAALEDGKG--KCP 160

  Fly   185 YDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKW 249
            |||....|.:.|:.       .|||.|...|...:.||.|      :..:..|..|.  :|...|
Zfish   161 YDPAKGHTGLIVDK-------ELYSATLNNFLGTEPVILR------NLGQQHYSMKS--EYLPAW 210

  Fly   250 LDKPNFVGSFDIGE----------YVYFFFRETAVEYINC-GKAVYSRIARVCKKDVGGKNLLAH 303
            |::||||||..:.|          .:||||.|.||| ::| .....:|:|||||.|:||...|..
Zfish   211 LNEPNFVGSALVRESRNSKDGDDDKIYFFFSERAVE-LDCDSDLTVARVARVCKGDLGGTRTLQK 274

  Fly   304 NWATYLKARLNCSISGEFP---FYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHI 362
            .|.|:.||||.||    ||   ..||.:::|:.||....|   |:..|......:..||||.:.|
Zfish   275 KWTTFQKARLMCS----FPERHITFNNLRAVFTLPGADWRTTSFYGIFHAQWGDVDVSAVCQYQI 335

  Fly   363 NEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCV---------NDTSNLPDTVLNFIRSHP 418
            .|::..|:|.:||...|:..| ......||.||||.|:         |.:..|||..|||.:.||
Zfish   336 GEVKNVFDGPYKEYRESSQRW-GRYTGTVPSPRPGACITNFDRENGYNSSLQLPDATLNFAKKHP 399

  Fly   419 LMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQ-EYIVYYVGTNLGRIYKIVQYYRNGESL 482
            ||:.   .....|:...:.:.||:|.||  |:..|:| .|.:.::||..|.:.::|........:
Zfish   400 LMEL---RAEARPLLLTKGINFTRLAVD--RVSSLDQRSYNMLFIGTADGWLQRVVILGSEAHVI 459

  Fly   483 SKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDK 545
            .: :.:|:  ..:.:..:.||.::|.||||:...:.|:.||.|: ||.:...|:  |||||.||.
Zfish   460 EE-IQLFD--RQQPVDSLTISHSKKYLYIGSRSEVLQLPLANCS-RYHSQPDCLLSRDPYCAWDS 520

  Fly   546 EANTCRPYELDLLQDVANETSDICDSSVLK-----------------------KKIVVTYGQSVH 587
            |...|  ..:||.:   ..||.:....:|:                       :.:.|..|..:.
Zfish   521 EGRAC--VRIDLHR---GSTSTLSQDLMLERFNRGKAKFDKPFSIPSPDHSRLRNVTVVVGSDLV 580

  Fly   588 LGCFVKIPEVLKN-EQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDCH 648
            |.|     .::.| .|..|..:.::....|......:: :...|.||:........|||.|:
Zfish   581 LPC-----NLVSNLAQPFWELNERELALVEGEAIGPRF-DRALRALVIPQAGSLQAGRYICY 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	152/483 (31%)
		Ig_Semaphorin_C	573..664	CDD:143180	16/100 (16%)
sema4c	NP_001121718.1	Sema_4C	40..497	CDD:200519	154/492 (31%)
		PSI	498..541	CDD:279745	17/48 (35%)
		Ig	569..656	CDD:299845	15/74 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910