DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and si:dkey-49n23.1

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_021329223.1	Gene:	si:dkey-49n23.1 / 558742	ZFINID:	ZDB-GENE-050208-762	Length:	758	Species:	Danio rerio

Alignment Length:	807	Identity:	223/807 - (27%)
Similarity:	366/807 - (45%)	Gaps:	177/807 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADH--VREFNCGKLY- 67
            |..||.|.||.|::                          ||.|..:....|  :|..|...::
Zfish    11 LFSLLVLSLLHCNA--------------------------GNQNTPRLQLTHTELRSRNGSAVFW 49

  Fly    68 -------YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTR--------DDVVS 117
                   |:...::|||..|.||..|.::.:|..:::           :|:|        :.:..
Zfish    50 DGGEGGAYQALLLDEDRGWLLVGGRDHIYMLNSDSLT-----------QPSRKIHWPAGQEHIER 103

  Fly   118 CVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTH---LPRSEYVIGVG-L 178
            |...||:...||.|:||::|..:: ..:|||||.|.:|:  ..|.:|.|   .|..:.:..|| .
Zfish   104 CKYAGKNLSMDCANYVRLLQPFNK-THVYVCGTGAFHPQ--CTYIDLGHNLEKPTFQLLSHVGES 165

  Fly   179 GIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTL 243
            |..|||:.|.:..|| ::.:|.      ||:||..:|...:..||||.:::.:     ..:.||.
Zfish   166 GRGKCPFSPQEPFTA-HLTDGE------LYAGTAVDFMGTNAAIFRTSVHSNN-----QHYIRTE 218

  Fly   244 KYDSKWLDKPNFVGSFDI-------GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLL 301
            .|...||::|.||||:.|       .:.|||||:|||||.....|.:|||:|||||.|:|||..|
Zfish   219 AYQDHWLNEPEFVGSYSIPDTHSLDDDKVYFFFKETAVESNQLDKRIYSRVARVCKNDIGGKRSL 283

  Fly   302 AHNWATYLKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFH 361
            .:.|:|:|||||.|::.|.  ...:|:|::.::.|.:...:   .:..|:||::...|||||.:.
Zfish   284 INRWSTFLKARLVCTVPGPGGMDTHFDELEDIFLLETKDPQNPVIYGVFSTSSSVFRGSAVCVYS 348

  Fly   362 INEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVND--------TSNLPDTVLNFIRSHP 418
            :..|:|||||.|..:.|.:..|:. ...::|.||||||.::        |.:.||.|::|:|:|.
Zfish   349 MASIRAAFNGPFAHKESPDYRWME-YKGKIPYPRPGTCPSETYDALYKSTRDFPDDVVSFMRAHQ 412

  Fly   419 LMDKAVNHEHNNPVYYKRDLVF--TKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGES 481
            ||.:.|...|..||:.:.:..:  .|||||  |:|..:.:|.|.::||:.||:.|:|...:....
Zfish   413 LMWEPVVPIHRRPVFTRINTPYRLKKLVVD--RVDAEDGQYDVLHLGTDDGRVLKVVSVPKENWE 475

  Fly   482 LSKL----LDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPY 540
            :.::    |::|:.  ...|..||:|..|:.|:|.:|..:.|:.:..|......|..|  .||||
Zfish   476 IEEIILEELNVFKT--QTPILSMELSTKRQVLFISSDENVVQLPVQRCELYGKACVDCCLARDPY 538

  Fly   541 CGWDKEANTCRPY-----ELDLLQDVA-----NETSDICDSSVLKKKIVVTYG---QSVHLGCFV 592
            |.||  .::|..|     .....|||.     ::..|:.|.|. ..::...||   .|..|.|..
Zfish   539 CAWD--GSSCTNYFPSNKRRARRQDVRYGDPWSQCQDMRDGSE-NAELKTVYGVETNSTFLECVS 600

  Fly   593 KIPEVLKNEQVTWY---HHSKDK-----GRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC-- 647
            ..|:.    .:.|.   :||::.     |...:.:        .:|||::..:...:.|.|.|
Zfish   601 NSPQA----TIKWIFQPNHSQNSKELVPGEENLLH--------MQRGLLLQQITSTNAGLYLCMA 653

  Fly   648 --HLGGSLLCSYNITV-------DAHRCTPPNKS---NDYQKIY---------SDWCHEF----- 686
              |.....|..|.:.|       .|....|.|.:   ..|::::         .::|...
Zfish   654 FEHSFSRTLARYELHVIPQNQMSRAQNNLPGNHATSLRSYKELHLMGVGGLTADEYCEHLWYREK 718

  Fly   687 -EKYKTAMKSW----EKKQAQCSTRQN 708
             .::|.....|    |.::|:. .|||
Zfish   719 RRQHKHRTLKWKQVSENRKARV-RRQN 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	160/502 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	20/112 (18%)
si:dkey-49n23.1	XP_021329223.1	Sema_3	48..521	CDD:200500	160/503 (32%)
		PSI	520..557	CDD:214655	12/38 (32%)
		Ig_Semaphorin_classIII	581..672	CDD:143279	20/102 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020