DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and sema4f

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_005166611.1	Gene:	sema4f / 556003	ZFINID:	ZDB-GENE-130530-860	Length:	797	Species:	Danio rerio

Alignment Length:	709	Identity:	198/709 - (27%)
Similarity:	303/709 - (42%)	Gaps:	136/709 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLYYRTFHM 73
            |..|.:||||::|..:|..                   |:|    ||:..|....|.|  .||.:
Zfish     7 LFVLSVLLCSTLSSWSATV-------------------NSN----GAEFPRLSGFGNL--STFLL 46

  Fly    74 NEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQS 138
            :.:...||:||.|.|..|:...:|     :.:|......|...|||:|||:: .||:|:||:::.
Zfish    47 HSESGMLYLGARDAVIVVDTAKLS-----KKMIEWSVPEDRRKSCVAKGKTE-DDCRNYVRLLEF 105

  Fly   139 MDQGDRLYVCGTNAHNPKDYVIYANLTHLPR-SEYVIGVGLGIAKCPYDPLDNSTAIYVENGNPG 202
            :|.| |:|.|||.|.:|:...|..:...|.: .:..|.:..|..|||::|....||:..     |
Zfish   106 LDDG-RIYACGTFAFDPQCAFINISTFSLEKQDDGFIKMETGKGKCPFEPSQPYTAVMA-----G 164

  Fly   203 GLPGLYSGTNAEFTKADTVIFRTDLYNTS-AKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGE--- 263
            |:  ||:...:.|...        :|:.| |..:|.:..|| :....||..|.|:.|..|.|
Zfish   165 GI--LYTAVTSNFLGT--------MYDISRATGIEQERIRT-EQSINWLSDPEFISSAFIQEDAK 218

  Fly   264 --------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCS--IS 318
                    .:||||.|.|.||....|....|:|||||.||||...|...|.|:|||:|.|.  .|
Zfish   219 NNPTGEDDKIYFFFTEVAKEYDLYTKVKVPRVARVCKSDVGGMKTLQRRWTTFLKAQLVCEDRAS 283

  Fly   319 GEFPFYFNEIQSVYQLPSDKS--RFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNS 381
            |:......::.:|...|.|.|  .|:..||:.......||||.:.:.||....||.|||...|..
Zfish   284 GQRFNILTDVFTVQHQPGDPSSTHFYGIFTSQWEREELSAVCVYSLEEITKVMNGPFKELKKSCE 348

  Fly   382 AWL-PVLNSRVPEPRPGTCVN---------DTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKR 436
            .|: |   ..:|.||||.|:|         .:..|||.||.|:|.||||:.:|...   |:..:.
Zfish   349 NWINP---EPIPTPRPGQCLNSDQRELGFESSLKLPDKVLTFMRDHPLMENSVVAV---PLMIRY 407

  Fly   437 DLVFTKLVVDKIRIDILNQEYI--VYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPNEAIQV 499
            .:.:|||.|.........:::|  |.::||:.|.::|:.....|...:.::.......|     |
Zfish   408 GITYTKLAVTLTPAFSGQKQHITTVLHLGTDHGELHKVAVVGPNATLIEEITLFSAQEP-----V 467

  Fly   500 MEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCVR--DPYCGWDKEANTC---RPYELDLLQ 559
            ..|...:....:|:.|.:.::.:..|: .|.:|..|.|  ...|.|......|   :|.|:...:
Zfish   468 NNILLYKGEAVVGSPHSLVKLPILGCS-LYSSCEVCARAGGLGCIWRHNRPACAMAKPGEVVEAE 531

  Fly   560 DV---ANETSDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYH----HSKDKGRYEI 617
            |:   .|:...:|...|::.::|  .|..|.|.|....|     ....|.|    |::.. .|::
Zfish   532 DLVRQCNKREGLCSPPVIEMRVV--EGLRVLLSCVQLSP-----RPCHWDHPPGSHTRHH-NYDL 588

  Fly   618 RYSPTKYIETTERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDAHRCTPPNKSNDYQ 676
            .      ::.|.:.|          |.|.|      ||.     :|.|..||.:...||
Zfish   589 E------VQITNKSL----------GIYVC------LCD-----EAGRDQPPCRKAVYQ 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	147/485 (30%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	18/94 (19%)
sema4f	XP_005166611.1	Sema	36..490	CDD:301699	148/489 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100