DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and sema3gb

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_005167089.1	Gene:	sema3gb / 544660	ZFINID:	ZDB-GENE-050513-4	Length:	746	Species:	Danio rerio

Alignment Length:	742	Identity:	208/742 - (28%)
Similarity:	339/742 - (45%)	Gaps:	140/742 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVVSCVSKGKSQIFDCK 130
            ||..||::|:..||:|:.:.:..:::||:     |::  :|:...|......|...||....:|.
Zfish    51 YRILHMDQDQGRLYLGSREYLVSLDMQNV-----NKEPLIIHWPATTQRKGECKLTGKGGQGECA 110

  Fly   131 NHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPR----SEYVIG-----VGLGIAKCPYD 186
            |.||:|:..:: ..||.|||.|:.|       ..|.:.|    .||:..     |..|..|.|||
Zfish   111 NFVRLIEPWNR-THLYTCGTGAYKP-------ICTFINRGWRAEEYLFRLVPGYVDSGKGKSPYD 167

  Fly   187 PLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLD 251
            |...:.|..: |||      ||||.:.:|...|..|||| |.:..|.|.|       :|||:||:
Zfish   168 PRQENAAALI-NGN------LYSGVHVDFMGTDPAIFRT-LGDRPAVRTE-------QYDSRWLN 217

  Fly   252 KPNFVGSFDI-------GEYVYFFFRETAVEYINCGKA--VYSRIARVCKKDVGGKNLLAHNWAT 307
            :|.|:....|       .:.:||||||.::: .:.|.|  |.:|:.|||..|.||:..|.:.|.|
Zfish   218 EPVFIKIQKIPDSAEKNDDKLYFFFREKSLD-ASGGSAPSVLARVGRVCLNDDGGQRSLVNKWTT 281

  Fly   308 YLKARLNCSISGE--FPFYFNEIQSVY-QLPSDKSR--FFATFTTSTNGLIGSAVCSFHINEIQA 367
            :|||||.||:.|.  ...||:|::.|: |...|:..  .:|.|:|:.:...|||||.:.:::|:.
Zfish   282 FLKARLVCSVIGADGVETYFDELRDVFIQRTHDERNPIVYAVFSTAGSVFKGSAVCVYSMSDIRN 346

  Fly   368 AFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAV 424
            .|||.|..:...|..|.| ...::|.||||||        ::.|....|..:||:|:||||.:.:
Zfish   347 VFNGPFSHKHGHNYQWTP-YTGKIPYPRPGTCPGGTFTPDLHTTKAFSDEAVNFVRAHPLMYQPI 410

  Fly   425 NHEHNNPVYYKR--DLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLL- 486
            ...|..|:..:.  |..||.:.||  .:|.::..|.|.::||:.|.:.|::...::..:..:|:
Zfish   411 YPIHKRPLVVRTGVDYRFTTIAVD--LVDAVDGRYEVLFLGTDRGTVQKVIVLPKDISTTEELIL 473

  Fly   487 ---DIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKE 546
               ::|:..  .|::.::||..|:.||:.::..:.|:.|..|......|..|  .|||||.||.|
Zfish   474 EEVEVFKTP--AAVKTLKISTKRQQLYVSSERGLTQVSLHRCAVYGKACSDCCLARDPYCAWDGE 536

  Fly   547 ---ANTCRPYELDLLQDVAN-ETSDICD--SSVLKKKIVVTY-----GQSVHLGCFVKIPEVLKN 600
               |.|.........||:.: :....|.  ::.::|::..|.     |.|..|.|..:.|:.
Zfish   537 HCSAFTPATKRRSRRQDIKHGDPLRQCRGFNAKVEKRLRETVQFGVEGSSTFLECQPRSPQA--- 598

  Fly   601 EQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC--------HLGGSL---- 653
             .|.|. ..||..|..:  |..|.:..|..|:::.|:.::|.|.|.|        |....:
Zfish   599 -TVKWL-FQKDGRRKAL--SRDKEVLKTGHGILLKSLTQSDAGLYHCLATENNFKHTLARISLRI 659

  Fly   654 --------LCSYNITVD-------AHRCTPPN-------------KSNDYQKIYSDWCHEFEKYK 690
                    |...:|.:|       :|:..||.             ......::.:.:|   :.|:
Zfish   660 LDREIVEALTESDIPIDPEHRRHHSHQHPPPPPPPPQAHPPALPLHPQPEVRLINQYC---QSYR 721

  Fly   691 TAMKSWEKKQAQCSTRQNFSSNQHPNE 717
            ..|:|    |.|.:.|.|......|.|
Zfish   722 QQMQS----QPQKAKRNNRRHTGEPEE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	153/493 (31%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	25/122 (20%)
sema3gb	XP_005167089.1	Sema_3F	42..513	CDD:200515	154/495 (31%)
		PSI	512..558	CDD:214655	15/45 (33%)
		Ig_Semaphorin_classIII	576..662	CDD:143279	21/92 (23%)
		IG_like	581..651	CDD:214653	19/76 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910