Protein Alignment Sema2a and sema3ga

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001014823.1
• Gene: sema3ga / 544659
• ZFINID: ZDB-GENE-050513-3
• Length: 749
• Species: Danio rerio
• Alignment Length: 650
• Identity: 185/650 - (28%)
• Similarity: 300/650 - (46%)
• Gaps: 129/650 - (19%)

  Fly    68 YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVVSCVSKGKSQIFDCK 130
            ||..|::.|:..||:|:.:.:..:::|||     |::  :|:..........|...||.:..:|.
Zfish    59 YRILHVDPDQGRLYLGSREYLVSLDMQNI-----NKEPLIIHWPAPAQRKGECQLTGKGRHGECA 118

  Fly   131 NHVRVIQSMDQGDRLYVCGTNAHNP-----------KDYVIYANLTHLPRSEYVIG-VGLGIAKC 183
            |.||:|:..:: ..||.|||.|:.|           :||:.          ..|.| |..|..||
Zfish   119 NFVRLIEPWNR-THLYTCGTGAYKPICTFINRGWRAEDYLF----------RLVPGYVDSGKGKC 172

  Fly   184 PYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSK 248
            .|||...:.|..: |||      ||:|...:|...|..|||| :.:..|.|.|       :||||
Zfish   173 SYDPNQENVASLI-NGN------LYAGVAVDFMSTDPGIFRT-MGSRPAVRSE-------QYDSK 222

  Fly   249 WLDKPNFVGSFDIG-------EYVYFFFRETAVEYINCGKA---VYSRIARVCKKDVGGKNLLAH 303
            ||::|.||....|.       :.:||||||.:::  :.|.|   |.:::.|||..|.||:..|.:
Zfish   223 WLNEPVFVQMKQISDSSEKNDDKLYFFFREKSLD--SGGGASPSVLAKVGRVCLNDEGGQKSLVN 285

  Fly   304 NWATYLKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHIN 363
            .|.|:|||||.||:.|:  ...:|:|::.|:..||...|   .:..|:||.:...|||||.:.:.
Zfish   286 KWTTFLKARLVCSVMGDDGVETFFDELRDVFIQPSQDERNPIVYGVFSTSGSVFKGSAVCVYSMA 350

  Fly   364 EIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSNLPDTVLNFIRSHPLM 420
            :|:..|||.|..:...|..| .....::|.||||||        :..|....|..:||||:||||
Zfish   351 DIRNVFNGPFAHKHGHNYQW-TTYTGKIPYPRPGTCPGGTFTPGLQSTKEFSDEAVNFIRAHPLM 414

  Fly   421 DKAVNHEHNNPVYYKR--DLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLS 483
            ...|...|..|:..:.  |..||.:.||  ::|.::..|.|.::||:.|.:.|::...::..::.
Zfish   415 YHPVYPIHKRPLVVRSGVDYRFTTIAVD--QVDAVDGRYEVLFLGTDRGTVQKVIVLPKDPTTME 477

  Fly   484 KL----LDIFEV-APNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYC 541
            :|    :::|.. ||   ::.|.||..|:.||..::..:.|:.|..|......|..|  .|||||
Zfish   478 ELTLEEVEVFRTPAP---VKTMHISAKRQQLYASSEVGLTQMSLHRCGVYGKACSDCCLARDPYC 539

  Fly   542 GWDKE-----------------------ANTCRPYELDLLQDVANETSDICDSSVLKKKIVV-TY 582
            .||.:                       ...||.|...:             ...||:|:.. ..
Zfish   540 AWDGDNCSAFTQATKRRSRRQDVKHGDPLRQCRGYNAKV-------------ERRLKEKVQFGVE 591

  Fly   583 GQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            |.|..|.|..:.|:.    .:.|.:  :.:||.::.....:.:.|.: |:::.::.:|:.|:|.|
Zfish   592 GSSTFLECVPRSPQA----TIKWLY--QKEGRRKVLNRDGEVLRTPQ-GVLLKALTKAEAGQYHC 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	154/498 (31%)
		Ig_Semaphorin_C	573..664	CDD:143180	16/75 (21%)
sema3ga	NP_001014823.1	Sema	50..521	CDD:301699	155/500 (31%)
		PSI	520..557	CDD:214655	10/36 (28%)
		Ig_Semaphorin_classIII	584..670	CDD:143279	14/72 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9670
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910