DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2a and SEMA5B

DIOPT Version :9

Sequence 1:NP_477507.1 Gene:Sema2a / 36846 FlyBaseID:FBgn0011260 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_001243276.1 Gene:SEMA5B / 54437 HGNCID:10737 Length:1205 Species:Homo sapiens


Alignment Length:744 Identity:227/744 - (30%)
Similarity:347/744 - (46%) Gaps:151/744 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGN----------NNYGKHGADHVRE 60
            |.|.|.||:...||..:.:::..:      |:..|..:....          :|:...||   |:
Human   124 LLPSLTLLVSHLSSSQDVSSEPSS------EQQLCALSKHPTVAFEDLQPWVSNFTYPGA---RD 179

  Fly    61 FNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQ 125
            |:       ...::...:.|.|||.:.:||::|.|:|..... :..:.|.||.   ||.||||::
Human   180 FS-------QLALDPSGNQLIVGARNYLFRLSLANVSLLQAT-EWASSEDTRR---SCQSKGKTE 233

  Fly   126 IFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDN 190
             .:|:|:|||:  :..|.::::|||||.:|  ......:.:|.|:...|.   |:|:|||||..|
Human   234 -EECQNYVRVL--IVAGRKVFMCGTNAFSP--MCTSRQVGNLSRTIEKIN---GVARCPYDPRHN 290

  Fly   191 STAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNF 255
            |||:....|.      ||:.|..:|:..|..|:|:   ..|...|     ||.:|:||||::|||
Human   291 STAVISSQGE------LYAATVIDFSGRDPAIYRS---LGSGPPL-----RTAQYNSKWLNEPNF 341

  Fly   256 VGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE 320
            |.::|||.:.|||.||.|||: :||:.||||:|||||.||||:.||...|.|::|||||||..||
Human   342 VAAYDIGLFAYFFLRENAVEH-DCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGE 405

  Fly   321 FPFYFNEIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLP 385
            .|||:||:||.:.|| ::...:..|||:.|.:..||||:|:::.|..||||.|:.|.:..:||||
Human   406 VPFYYNELQSAFHLP-EQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLP 469

  Fly   386 VLNSRVPEPRPGTC--VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKI 448
            :.|. :|..:.||.  .....||.:..|...:...||.:||......|...:..:.|:.||||.:
Human   470 IANP-IPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLV 533

  Fly   449 RI-DILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAP--NEAIQVMEISQTRKSLY 510
            :. |.|   |.|.|:||..|.|.|.:...........|.::..:.|  .|.::.:.|..:.::|:
Human   534 QAKDTL---YHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALF 595

  Fly   511 IGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCRPYELDLLQDVANETSDICDSSV 573
            :|....:.::.|..| ..|.:...|:  ||||||||.:...|     ..|:|.:|          
Human   596 VGLRDGVLRVPLERC-AAYRSQGACLGARDPYCGWDGKQQRC-----STLEDSSN---------- 644

  Fly   574 LKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYE-IRYSPTKYIETTERGLVVVSV 637
                 :..:.|:: ..|.|:        .||     :|.|... ..:.|.::::....|..:...
Human   645 -----MSLWTQNI-TACPVR--------NVT-----RDGGFGPWSPWQPCEHLDGDNSGSCLCRA 690

  Fly   638 NEADG-----GRYDCHLGGSL---LCSYNITVDAHRCTPPNKSNDYQKIYSDWCHEFEKYKTAMK 694
            ...|.     |..|| ||.::   .||.|                     ..|        |...
Human   691 RSCDSPRPRCGGLDC-LGPAIHIANCSRN---------------------GAW--------TPWS 725

  Fly   695 SWEKKQAQCST--------RQNFSSNQHP 715
            ||    |.|||        ||...||..|
Human   726 SW----ALCSTSCGIGFQVRQRSCSNPAP 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2aNP_477507.1 Sema_2A 66..523 CDD:200499 166/461 (36%)
Ig_Semaphorin_C 573..664 CDD:143180 18/99 (18%)
SEMA5BNP_001243276.1 Sema_5B 172..608 CDD:200525 170/477 (36%)
PSI 609..656 CDD:279745 16/68 (24%)
TSP1 667..718 CDD:214559 10/51 (20%)
TSP1 721..774 CDD:214559 13/42 (31%)
TSP1 779..825 CDD:214559
TSP1 910..962 CDD:214559
TSP1 967..1019 CDD:214559
TSP_1 1023..1064 CDD:278517
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9633
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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