DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and sema3fl

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_012823711.1	Gene:	sema3fl / 448771	XenbaseID:	XB-GENE-940271	Length:	700	Species:	Xenopus tropicalis

Alignment Length:	741	Identity:	217/741 - (29%)
Similarity:	332/741 - (44%)	Gaps:	127/741 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLQLSPLLALLLLLCSSVSETAADYENTWNFYYE-RPCCTGNDQGNNNYGKHGADHVREFNCG 64
            |.:..|.|||.|||.|...|..|...     ..|.. |.........:..:|.:.:|
Frog     6 MLVSALPPLLLLLLNLPPCVRTTRPP-----RVYLSYRDLMESRSARSFTFGFNTSD-------- 57

  Fly    65 KLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVVSCVSKGKSQIF 127
               ||...:::|:|.:|||:.|.|..::|.||     ||:  :|:.....:....|:..|:.::.
Frog    58 ---YRILLLDQDQDRMYVGSRDYVLSLDLGNI-----NREPLIIHWPAPLNRHKECLMAGRGRVD 114

  Fly   128 DCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSE-YVI-----GVGLGIAKCPYD 186
            :|.|::||||.::: ..||.|||.|:.|:..|||...    ||| ||.     .:..|..:||||
Frog   115 ECYNYLRVIQPLNR-THLYACGTGAYQPQCAVIYRGW----RSEDYVFRIVPASLESGKGRCPYD 174

  Fly   187 PLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLD 251
            |...:.|..::     |:  ||:|...::...|:.||||..:....        ||.:|||:||:
Frog   175 PKQENMATLID-----GV--LYAGVQVDYMGTDSAIFRTMGHKPPI--------RTEQYDSRWLN 224

  Fly   252 KPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYL 309
            .|.||||..:.|       .:|..|||.::|..| |.|:.|||||||..|.||...|...|.:||
Frog   225 DPLFVGSLVVSESSFKEDDKLYILFRERSLEGEN-GPALVSRIARVCLNDEGGLRSLVGKWTSYL 288

  Fly   310 KARLNCSISGE--FPFYFNEIQSVYQLPS-DKSR--FFATFTTSTNGLIGSAVCSFHINEIQAAF 369
            ||||.||:.|:  ....|::::.|:..|: ||..  .:..|||..:...|||||.:.:.:::|.|
Frog   289 KARLVCSVIGQDGVETSFDQLRDVFIQPTHDKQNPLIYGVFTTLGSVFRGSAVCVYSLADVRAVF 353

  Fly   370 NGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVNDTS--------NLPDTVLNFIRSHPLMDKAVNH 426
            ||.|..: ..:...:...:.:.|.||||.|....|        |..:.||.|:|:||||..:|..
Frog   354 NGPFAHK-EGHGYQMTAYSGKTPYPRPGACAGGFSVPRNRSSRNFGEDVLRFVRTHPLMYSSVYP 417

  Fly   427 EHNNPVYYKRD--LVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKL---- 485
            .:..|:....|  ..:|.:.||  |:...:.||.|.::||:.|.:.|::...|..:....:
Frog   418 VNRRPLLLLSDASYTYTSIAVD--RVPAADGEYTVLFLGTDRGTVQKVMILPRGTKETESITLEE 480

  Fly   486 LDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEA- 547
            :::|:|.  ..|:.:.||..|..||:.:|..:.|:.|..|.|..|:|..|  .|||||.||.:.
Frog   481 VEVFKVP--SPIRNLRISSKRHQLYVSSDVGVTQLSLHRCGRYGDSCADCCLARDPYCAWDGKGC 543

  Fly   548 --NTCRPYELDLLQDVAN-ETSDIC-------DSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQ 602
              .|..|......|||.: :....|       |..:.::..:...|.|.:|.|....|    .|.
Frog   544 VRYTPSPSRRSRRQDVKHGDPLRQCRGYNTQVDRGIAERLQISVEGGSAYLQCDTHSP----LES 604

  Fly   603 VTW-YHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC------------------- 647
            ||| ......:.|.|:|.|      ..:.|.|:.||..:|.|.|.|
Frog   605 VTWLLQRDGSQHRREVRLS------AIDGGAVLRSVQASDAGVYTCTGTENGFRRSRAKIRLNVL 663

  Fly   648 --HLGGSLLCSYNITVDAHRCTPPNK 671
              .|...|..:..:...|.:|.||.:
Frog   664 PRDLLEKLTAAPTLAPMAAQCPPPRR 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	155/490 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	23/112 (21%)
sema3fl	XP_012823711.1	Sema	49..518	CDD:301699	158/510 (31%)
		PSI	517..554	CDD:214655	14/36 (39%)
		Ig_Semaphorin_classIII	579..665	CDD:143279	21/95 (22%)
		IG_like	587..662	CDD:214653	21/84 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000