Protein Alignment Sema2a and sema6ca

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: XP_068071205.1
• Gene: sema6ca / 406272
• ZFINID: ZDB-GENE-040426-1933
• Length: 934
• Species: Danio rerio
• Alignment Length: 792
• Identity: 233/792 - (29%)
• Similarity: 361/792 - (45%)
• Gaps: 145/792 - (18%)

  Fly     2 SLLQLSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGND--------QG---NNNYGKHGA 55
            |::....|||.||.|.:|.:....|.:..        ...|.|        ||   :|...:.|.
Zfish    52 SVIMAMVLLAWLLPLITSATPFPRDLQPI--------SVVGLDDSYLYPSFQGLVSSNETERLGL 108

  Fly    56 DHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVS 120
            |:.|       ..|..||      ||:.|.|.||.|||.........:.::....|  ||..|..
Zfish   109 DYQR-------MMRIQHM------LYIAARDHVFVVNLTTAVDEIIPQQILTWRST--DVSKCTV 158

  Fly   121 KGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNP--KDYVIYANLTHLPRSEYVIGVGLGIAKC 183
            :|::. .:|.|:::|:...:. :.|:.|||||.||  ::|       .|...|.|....||.|:|
Zfish   159 RGRNS-DECYNYIKVLVPRND-ETLFACGTNALNPACRNY-------RLSSLEQVGQELLGQARC 214

  Fly   184 PYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSK 248
            |::...::..::.     ||  ..||.|..:|..:|.||:|: |.......|     ||:|||||
Zfish   215 PFESRQSNVGVFA-----GG--HFYSATVTDFQASDAVIYRS-LGGEGRPVL-----RTVKYDSK 266

  Fly   249 WLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGK-NLLAHNWATYLKAR 312
            ||.:|:|:.:.:.|.||||||.|.|||:...||.||||:|||||.|.||. .:|..:|.::||||
Zfish   267 WLREPHFLHAVEYGNYVYFFFSEIAVEHTAAGKVVYSRVARVCKNDNGGSTRVLDRHWTSFLKAR 331

  Fly   313 LNCSISGEFPFYFNEIQS---VYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFK 374
            ||||:.|:..|||:.:||   |.|: :.:......|||.||.:.|||||.|::::|:..|||:||
Zfish   332 LNCSVPGDTFFYFDVLQSLTNVLQI-NQRPAVVGVFTTQTNSIPGSAVCGFYLDDIERVFNGRFK 395

  Fly   375 EQSSSNSAWLPVLNSRVPEPRPGTCVNDTS--------NLPDTVLNFIRSHPLMDKAVNHEHNNP 431
            ||.:|:|.|..|...:||:||||:|..:.|        ..||:||:||::||||:::|...::.|
Zfish   396 EQKNSDSMWTAVPEEQVPKPRPGSCAGEGSASSYSSSVQFPDSVLSFIKTHPLMEESVPSVNSQP 460

  Fly   432 VY------YKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIV-QYYRNGESLSKLLDIF 489
            :.      ||    .|::|||.......|:  .|.::|:..||:.||: ..:.|....|:||:..
Zfish   461 LITNTASSYK----LTQIVVDTAAGPHKNR--TVVFLGSEDGRVLKILTNTHTNSSHTSQLLEDI 519

  Fly   490 EV------APNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGW--- 543
            :|      ....|:..:|:.:...:|::.....:.::.|:.|.:......||:  .||||.|
Zfish   520 DVFNPTRCVGERAVLGLELDKEHHALFVAFSSCVIRVPLSRCAQHATCRRRCLYTHDPYCIWLRT 584

  Fly   544 DKEANTCRPYELDLLQDVANE-------TSDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNE 601
            .:.|:....::....||:..|       .:|:..|:....|..|.....|.     ::|:.  :.
Zfish   585 GRCADMAPGFKAGFEQDIDGEQTHLFDTCTDVMSSAGSDVKSAVDSASGVK-----QLPDA--DS 642

  Fly   602 QVTWYHHSKDKGRYEIRYSPTKYIETTERGLVV--------VSVNEADGGRYDCH---LGGSLLC 655
            ....||.:.......:.:    .:.....||:|        .|..|.:......|   |..|.|.
Zfish   643 LSDGYHFTLLGACVLLAF----VLGAIASGLLVSCYCRQSSPSTPEPEATLAHTHAHTLSLSSLA 703

  Fly   656 SYNITVDAHRCTPPNKSNDYQK--IYS------------DWCHE--FEKYKTAMKSWEKKQAQCS 704
            ..|:.:|    ..|.|.::...  |||            |...|  .:..|.....||:.....|
Zfish   704 KINLLMD----NKPEKKSESPSAHIYSPAKPPEELPPTPDSTPELPIKNIKAISSQWERSHTHNS 764

  Fly   705 TRQNFSSNQ-HP 715
            |.|...:|| ||
Zfish   765 TLQLIPTNQSHP 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	167/483 (35%)
		PSI	527..>550	CDD:396154	8/27 (30%)
		Ig_Semaphorin_C	573..668	CDD:409368	17/105 (16%)
		Ig strand A	573..579	CDD:409368	1/5 (20%)
		Ig strand B	583..591	CDD:409368	1/7 (14%)
		Ig strand C	601..607	CDD:409368	0/5 (0%)
		Ig strand C'	609..612	CDD:409368	0/2 (0%)
		Ig strand D	622..626	CDD:409368	0/3 (0%)
		Ig strand E	630..637	CDD:409368	3/14 (21%)
		Ig strand F	643..652	CDD:409368	2/11 (18%)
		Ig strand G	655..668	CDD:409368	2/12 (17%)
sema6ca	XP_068071205.1	Sema	100..559	CDD:472829	171/502 (34%)