DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and Sema5c

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_611293.3	Gene:	Sema5c / 37066	FlyBaseID:	FBgn0284221	Length:	1093	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	234/832 - (28%)
Similarity:	368/832 - (44%)	Gaps:	190/832 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLLQLSPLLA-LLLLLCSSVSETAADYENTWNFYYERPC--CTGNDQGNNNYGKHGADHVREFN 62
            |.:|:|..:.: |.|||..|:........:|.:.|..:..  ...||....:|....:...|.::
  Fly     3 MLILKLPKMFSQLWLLLILSLLTLEGPQPSTGSGYTTKSSVDLLENDSRYISYQDLMSTAKRFYD 67

  Fly    63 CGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEP--------TRDDVVSCV 119
            ....:|.....:..|:.:.|||.|.::|::             .:|||        |..::..|.
  Fly    68 PETTWYSEMLFDVARNQVIVGARDTLYRMS-------------FDLEPLERASWGATPSEIAMCQ 119

  Fly   120 SKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLGIAKC 183
            :||:|:.: |:|:|||:.|..: ::||.|||||..|. .:....|||       |.||..|:.||
  Fly   120 AKGQSERW-CRNYVRVLHSYGE-NQLYACGTNAFQPSCSWRQMENLT-------VTGVDSGVVKC 175

  Fly   184 PYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSK 248
            |:.|..|||::...||.      |:.||..:|:.:|..|.||.:  .|.||    |.||.:|::.
  Fly   176 PFHPQANSTSLLQSNGQ------LFVGTATDFSGSDVAILRTGV--ESNKR----FLRTKQYNNN 228

  Fly   249 WLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDV-GGKNLLAHNWATYLKAR 312
            ||....|||||:.|.:|||..||:|.|:::|||.:|||:|||||.|| ||..||..||.::||||
  Fly   229 WLSGAQFVGSFEAGHFVYFLLRESAAEHMSCGKVIYSRVARVCKNDVGGGGQLLRDNWTSFLKAR 293

  Fly   313 LNCSISGEFPFYFNEIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQS 377
            ||||:.||:|:||:|||.:....|: |..:|||.||.:.:.|||||:::::.|.|||:|.||:|.
  Fly   294 LNCSLPGEYPYYFDEIQGMTYAESE-SILYATFRTSGSSIFGSAVCAYNLSSINAAFDGPFKQQE 357

  Fly   378 SSNSAWLPVLNSRVPEPRPGTCVNDTSNLPDTVLNFIRS--HPLMDKAVNHEHNNPVYYKRDLVF 440
            .|::||..|..::..:.:.||         .::.:::.|  :.|||:||......|:|:.:...|
  Fly   358 HSDAAWKTVNTNQRSQFQCGT---------SSIGHWLESSRYQLMDEAVQPIGAEPLYHSKLEQF 413

  Fly   441 TKLVVDKIRIDILN---QEYIVYYVGTNLGRIYKI-VQYYRNGESLSK-LLDIFEVAPNEAIQVM 500
            .:|.     :||:|   ::..|.:|.::...|.|: |:|  :|:.:.. |:::::........::
  Fly   414 GRLA-----LDIINTKTEQVHVLFVASSGNHIKKLSVKY--DGDGVQTCLVELWQADDTGTSSLL 471

  Fly   501 EIS--QTRKSLYIGTDHRIKQIDLAMCNRR--YDNCFRCVRDPYCGWDKEANTCRPYELDLLQDV 561
            .::  :...|||:|||..:.:|....|:|.  ..:|...: ||||||::....|.|...
  Fly   472 NMAYLKVSDSLYLGTDLALTRIPAQHCSRHVSQSSCLNSM-DPYCGWNELVERCMPQPQ------ 529

  Fly   562 ANETSDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTW-------YHHSKDKG---RYE 616
                    |||||:.     :.|:..:.|.| :...:.....||       .|...|..   |..
  Fly   530 --------DSSVLQH-----WHQAPQITCPV-LNAPIDGGWSTWSPWAVCQQHEQPDSNCQCRQR 580

  Fly   617 IRYSP-------------TKYIETTERG---------------LVVVSVNE--------ADGGR- 644
            ...:|             |:....|:.|               .:.|.:..        |.|||
  Fly   581 SCNNPQPQHGGATCEGISTQVTNCTQHGGWTEWSAWSPCSQTCGIAVKIRRRTCGNPRPAFGGRT 645

  Fly   645 ---------YDCHL------------GG----------SLLCSYNITVDAHRCTPPNKSN----- 673
                     |..||            ||          |..|.....:....|..|...|
  Fly   646 CVGSEQSEMYCRHLPPCPVAKPQSVDGGWGPWGEWSECSAQCGGGFRMRRRECNDPAPLNGGMEC 710

  Fly   674 -----DYQKIYSDWCHEFEKYKTAMKSWEKKQAQCSTRQNFSSNQHPNEIFR 720
                 ||::.....|.|..|. :|...|     ...|....||..|....||
  Fly   711 PGCRLDYEECNMQSCQEVRKL-SAWTPW-----LTVTGSGNSSEPHMERRFR 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	164/475 (35%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	26/168 (15%)
Sema5c	NP_611293.3	Sema_5C	65..496	CDD:200526	164/481 (34%)
		PSI	497..546	CDD:279745	17/68 (25%)
		TSP1	556..607	CDD:214559	8/50 (16%)
		TSP1	610..663	CDD:214559	8/52 (15%)
		TSP1	674..725	CDD:214559	7/50 (14%)
		TSP1	802..834	CDD:214559
		TSP1	853..901	CDD:214559
		TSP1	906..953	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9633
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940