DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema1b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	185/514 - (35%)
Similarity:	276/514 - (53%)	Gaps:	64/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLE--PTRDDVVSCVSKGKSQIFDC 129
            |::....|:  :.:.|||.|.::.|:|..:      :::..||  .|..|...|..|||.: :||
  Fly    60 YFKILDHND--EFVLVGAKDVIYNVSLNGL------KEIARLEWHSTDADRELCALKGKHE-WDC 115

  Fly   130 KNHVRVIQSMDQGDRLYVCGTNAHNPK-----------DYVIYANLTHLPRSEY---VIGVGLGI 180
            .|::||......|:.| :||||::.|:           :....|...|..|.|.   |...||
  Fly   116 HNYLRVYALRPNGEVL-LCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGL-- 177

  Fly   181 AKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKY 245
              |||.|..|||..:.:.       .|||.|.|:|:..|.:|:|.:|             ||.:|
  Fly   178 --CPYSPAHNSTYAFADG-------HLYSATVADFSGGDPLIYRENL-------------RTEQY 220

  Fly   246 DSKWLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLK 310
            |.|.|::|:|||:.:...||.|||||.::|.:|.|||||||:|||||.|.||......:|.::||
  Fly   221 DLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLK 285

  Fly   311 ARLNCSISGEFPFYFNEIQSVYQL--PSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKF 373
            ||||||:.|||||||:|||::..:  ...||..:|.||||.|.:.|||||:|::::|.|||:|:|
  Fly   286 ARLNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEF 350

  Fly   374 KEQSSSNSAWLPVLNSRVPEPRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDL 438
            |.|..|.|.||||...:||:||||.||.|:..|....:|||::||||::||...|..|:..|.:|
  Fly   351 KSQKDSQSHWLPVEREQVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNL 415

  Fly   439 --VFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRN--GESLSKLLDI----FEVAP-N 494
              ..|.:.|......:....|.|.|.||:.|::.|.:.....  ..::.:|..:    .:|.| .
  Fly   416 HHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLG 480

  Fly   495 EAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCR 551
            ..|:.:.||.::.||.:.:|..:..:.|..|:...| |..|  ::||.|.||.:.:.|:
  Fly   481 TPIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVD-CLGCLSLQDPICAWDLQTHECK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	174/482 (36%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	175/484 (36%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910