Protein Alignment Sema2a and sema7a

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001315437.1
• Gene: sema7a / 324910
• ZFINID: ZDB-GENE-030131-3633
• Length: 640
• Species: Danio rerio
• Alignment Length: 626
• Identity: 162/626 - (25%)
• Similarity: 273/626 - (43%)
• Gaps: 123/626 - (19%)

  Fly    66 LYYRT-------FHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGK 123
            |.|.|       || .|...:|:||..:.|...::.:.       :::.......::..|   |:
Zfish    45 LNYNTNYSHTVLFH-EEGSKSLFVGGSNIVLHFDVDSY-------EILENFTLNANLPRC---GE 98

  Fly   124 SQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPL 188
            |   .|:|.|.||::..  :..:|||||...|:.:.:|...::....:.|.|.|:.    |:...
Zfish    99 S---SCENVVTVIETFQ--NCKFVCGTNGEEPQCWELYPRESNHSVVKSVEGTGIS----PHSSE 154

  Fly   189 DNSTAIYVENGNPGGLPGLYS-GTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDK 252
            .||.:: |.:|:......||| ||..:|.:            .:.||:      .:....:|:.:
Zfish   155 QNSLSL-VADGDLYAAAPLYSDGTLLQFRR------------KAGKRI------NVWMHDQWVSE 200

  Fly   253 PNFVGSF-------DIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGG-KNLLAHNWATYL 309
            |.|:.||       .:.|.:|..|||...:.........||:|||||.|.|| |..|.:.|.::|
Zfish   201 PTFISSFLAKRKNDSLNEKIYVLFREKNSDTSPEADPWISRVARVCKIDEGGSKQFLQNIWTSFL 265

  Fly   310 KARLNCSISGEFPFYFNEIQSVY-QLPSD--KSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNG 371
            ||||.|.|..| ..|||.:|.|: |...|  .|..:|.|::|.|   .:|||.:.:.::...|
Zfish   266 KARLVCGIPKE-SLYFNRLQDVFVQHAEDWRDSLVYALFSSSWN---STAVCIYSLADLDDIF-- 324

  Fly   372 KFKEQSSSNSAWLPVLNSRVPEPRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKR 436
               |:|:...     .:..:|.||||.||.::::||...|..|:.:|.|...::....:..::..
Zfish   325 ---EKSNYKG-----FSEAIPNPRPGKCVENSNSLPIPTLKIIKDYPEMKDWIHPIQKDTPFFTS 381

  Fly   437 DLVFTKLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEV------APN 494
            ...|||:|||:|| :|  ...|.|..:.|:.|.|:||:|:.      ||...|.|.      ||
Zfish   382 SKNFTKIVVDQIRALD--ENVYNVLLLATDDGMIFKILQHG------SKPFIISETHLCNGCAP- 437

  Fly   495 EAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCRPYELDL 557
              ||.|::...::.|::|...::..::|..|.....:|..||  |||||.|.::.  |.......
Zfish   438 --IQSMKLDSKKRKLFVGYPGQMSVLELQRCQDYGASCEECVLSRDPYCAWSEKG--CTSQTRGG 498

  Fly   558 LQDVAN-ETSDICD-------------SSVLKKKIVVTYGQSV--HLGCFVKIPEVLKNEQVTWY 606
            :|:::: ..:.:||             ||....:|..|....|  :|.|    |....:....|.
Zfish   499 IQNISDGNVTKVCDHKSVGRVRRDAQQSSTAPSRIQHTVATDVPFYLSC----PVDSHHASYRWE 559

  Fly   607 HHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            |..|..   ..:.:.::|:      |::.::...:.|.|.|
Zfish   560 HGGKSN---PCQQTQSEYL------LLIPAMTAENYGNYSC 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	131/482 (27%)
		Ig_Semaphorin_C	573..664	CDD:143180	14/77 (18%)
sema7a	NP_001315437.1	Sema	50..463	CDD:301699	128/476 (27%)
		PSI	465..505	CDD:214655	12/41 (29%)
		Ig	534..607	CDD:299845	13/71 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000