Protein Alignment Sema2a and Sema3f

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: XP_038937516.1
• Gene: Sema3f / 315996
• RGDID: 1308514
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 683
• Identity: 204/683 - (29%)
• Similarity: 315/683 - (46%)
• Gaps: 136/683 - (19%)

  Fly    54 GADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVV 116
            |..|...|......||....:||.|.:|||:.|.|..::|.:|     ||:  :|:...:...:.
  Rat    60 GTAHFFNFLLNTTDYRILFKDEDHDRMYVGSKDYVLSLDLHDI-----NREPLIIHWAASPQRIE 119

  Fly   117 SCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYAN---------LTHL----- 167
            .|:..||....:|.|.||:||..:: ..||||||.|:||  ...|.|         .|.:
  Rat   120 ECILSGKDGNGECGNFVRLIQPWNR-THLYVCGTGAYNP--MCTYVNRGRRSQAPPWTQMQVVRG 181

  Fly   168 ----------------PRSEYVI-----GVGLGIAKCPYDP-LDNSTAIYVENGNPGGLPGLYSG 210
                            ||.:|:.     .:..|..|||||| ||.::|:..|.        ||:|
  Rat   182 RGSRATDGADRPTPTAPRQDYIFYLEPEKLESGKGKCPYDPKLDTASALINEE--------LYAG 238

  Fly   211 TNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDI-------GEYVYFF 268
            ...:|...|..||||....|:        .||.:|:|:||:.|:|:.:..|       .:.:|||
  Rat   239 VYIDFMGTDAAIFRTLGKQTA--------MRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFF 295

  Fly   269 FRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE--FPFYFNEIQSV 331
            |||.:.|... ..|||:||.|:|..|.||...|.:.|:|:|||||.||:.||  ...:|:|:|.|
  Rat   296 FRERSAEAPQ-NPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDV 359

  Fly   332 YQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPE 393
            :...:...|   .:|.||:|.:...|||||.:.:.:|:..|||.|..:...|..|:| .:.::|.
  Rat   360 FVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPY 423

  Fly   394 PRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVF--TKLVVDKI 448
            ||||||        :..|.:.||.|:||:|:||||.:||......|:..:....:  |.:.||
  Rat   424 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTVAVD-- 486

  Fly   449 RIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLL----DIF-EVAPNEAIQVMEISQTRKS 508
            ::|..:..|.|.::||:.|.:.|::...::.:.:.:|:    ::| |.||   ::.|.||..|:.
  Rat   487 QVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAP---VKTMTISSKRQQ 548

  Fly   509 LYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPY-----ELDLLQDV----- 561
            ||:.:...:..:.|..|......|..|  .|||||.||.:|  |..|     .....|||
  Rat   549 LYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQA--CSRYTASSKRRSRRQDVRHGNP 611

  Fly   562 --------ANETSDICDSSVLKKKIVVTY---GQSVHLGCFVKIPEVLKNEQVTW-YHHSKDKGR 614
                    :|...:..:|        |.|   |.:..|.|..:.|:.    .|.| :.......|
  Rat   612 IRQCRGFNSNANKNAIES--------VQYGVAGSAAFLECQPRSPQA----TVKWLFQRDPSDRR 664

  Fly   615 YEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            .||| :..:::. ||:||::.::...|.|.|.|
  Rat   665 REIR-AEDRFLR-TEQGLLLRALQLGDRGLYSC 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	162/521 (31%)
		PSI	527..>550	CDD:396154	10/24 (42%)
		Ig_Semaphorin_C	573..668	CDD:409368	20/79 (25%)
		Ig strand A	573..579	CDD:409368	0/5 (0%)
		Ig strand B	583..591	CDD:409368	2/7 (29%)
		Ig strand C	601..607	CDD:409368	2/6 (33%)
		Ig strand C'	609..612	CDD:409368	0/2 (0%)
		Ig strand D	622..626	CDD:409368	0/3 (0%)
		Ig strand E	630..637	CDD:409368	2/6 (33%)
		Ig strand F	643..652	CDD:409368	3/5 (60%)
		Ig strand G	655..668	CDD:409368
Sema3f	XP_038937516.1	Sema_3F	65..565	CDD:200515	164/530 (31%)
		PSI	564..601	CDD:214655	13/38 (34%)
		Ig_Sema3	625..714	CDD:409455	21/85 (25%)
		Ig strand A	625..631	CDD:409455	1/13 (8%)
		Ig strand B	636..644	CDD:409455	2/7 (29%)
		Ig strand C	650..656	CDD:409455	2/9 (22%)
		Ig strand C'	658..661	CDD:409455	0/2 (0%)
		Ig strand D	671..675	CDD:409455	0/3 (0%)
		Ig strand E	678..685	CDD:409455	2/6 (33%)
		Ig strand F	691..700	CDD:409455	3/5 (60%)
		Ig strand G	703..714	CDD:409455