DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema3f

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_038937516.1	Gene:	Sema3f / 315996	RGDID:	1308514	Length:	802	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	204/683 - (29%)
Similarity:	315/683 - (46%)	Gaps:	136/683 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVV 116
            |..|...|......||....:||.|.:|||:.|.|..::|.:|     ||:  :|:...:...:.
  Rat    60 GTAHFFNFLLNTTDYRILFKDEDHDRMYVGSKDYVLSLDLHDI-----NREPLIIHWAASPQRIE 119

  Fly   117 SCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYAN---------LTHL----- 167
            .|:..||....:|.|.||:||..:: ..||||||.|:||  ...|.|         .|.:
  Rat   120 ECILSGKDGNGECGNFVRLIQPWNR-THLYVCGTGAYNP--MCTYVNRGRRSQAPPWTQMQVVRG 181

  Fly   168 ----------------PRSEYVI-----GVGLGIAKCPYDP-LDNSTAIYVENGNPGGLPGLYSG 210
                            ||.:|:.     .:..|..|||||| ||.::|:..|.        ||:|
  Rat   182 RGSRATDGADRPTPTAPRQDYIFYLEPEKLESGKGKCPYDPKLDTASALINEE--------LYAG 238

  Fly   211 TNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDI-------GEYVYFF 268
            ...:|...|..||||....|:        .||.:|:|:||:.|:|:.:..|       .:.:|||
  Rat   239 VYIDFMGTDAAIFRTLGKQTA--------MRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFF 295

  Fly   269 FRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE--FPFYFNEIQSV 331
            |||.:.|... ..|||:||.|:|..|.||...|.:.|:|:|||||.||:.||  ...:|:|:|.|
  Rat   296 FRERSAEAPQ-NPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDV 359

  Fly   332 YQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPE 393
            :...:...|   .:|.||:|.:...|||||.:.:.:|:..|||.|..:...|..|:| .:.::|.
  Rat   360 FVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPY 423

  Fly   394 PRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVF--TKLVVDKI 448
            ||||||        :..|.:.||.|:||:|:||||.:||......|:..:....:  |.:.||
  Rat   424 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTVAVD-- 486

  Fly   449 RIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLL----DIF-EVAPNEAIQVMEISQTRKS 508
            ::|..:..|.|.::||:.|.:.|::...::.:.:.:|:    ::| |.||   ::.|.||..|:.
  Rat   487 QVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAP---VKTMTISSKRQQ 548

  Fly   509 LYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPY-----ELDLLQDV----- 561
            ||:.:...:..:.|..|......|..|  .|||||.||.:|  |..|     .....|||
  Rat   549 LYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQA--CSRYTASSKRRSRRQDVRHGNP 611

  Fly   562 --------ANETSDICDSSVLKKKIVVTY---GQSVHLGCFVKIPEVLKNEQVTW-YHHSKDKGR 614
                    :|...:..:|        |.|   |.:..|.|..:.|:.    .|.| :.......|
  Rat   612 IRQCRGFNSNANKNAIES--------VQYGVAGSAAFLECQPRSPQA----TVKWLFQRDPSDRR 664

  Fly   615 YEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            .||| :..:::. ||:||::.::...|.|.|.|
  Rat   665 REIR-AEDRFLR-TEQGLLLRALQLGDRGLYSC 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	162/521 (31%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	20/79 (25%)
Sema3f	XP_038937516.1	Sema_3F	65..565	CDD:200515	164/530 (31%)
		PSI	564..601	CDD:214655	13/38 (34%)
		Ig_Sema3	625..714	CDD:409455	21/85 (25%)
		Ig strand B	639..643	CDD:409455	1/3 (33%)
		Ig strand C	651..655	CDD:409455	1/3 (33%)
		Ig strand E	678..682	CDD:409455	2/3 (67%)
		Ig strand F	692..697	CDD:409455	2/4 (50%)
		Ig strand G	709..712	CDD:409455
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11361
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910