DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and Sema5b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_038944267.1	Gene:	Sema5b / 303901	RGDID:	1308914	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	238/746 - (31%)
Similarity:	347/746 - (46%)	Gaps:	148/746 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQLSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQ------------GNNNYGKHGAD 56
            |.||.||....||.|.:| |:.|.  |.....|:..||..:.            .|..|     .
  Rat     7 LALSLLLPSFTLLLSHLS-TSQDI--TSEPSSEQQLCTRREHPIVAFEDLKPWVSNFTY-----P 63

  Fly    57 HVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSK 121
            .||:|:       ...::..|:.|.|||.:.:||::|.|:|..... :..:.|.||.   ||.||
  Rat    64 GVRDFS-------QLALDPSRNQLIVGARNYLFRLSLANVSLLQAT-EWASSEDTRR---SCQSK 117

  Fly   122 GKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYD 186
            ||:: .:|:|:|||:  :..|.::::|||||.:|  ......:.:|.|:...|.   |:|:||||
  Rat   118 GKTE-EECQNYVRVL--IVSGRKVFMCGTNAFSP--VCSSRQVGNLSRAIEKIN---GVARCPYD 174

  Fly   187 PLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLD 251
            |..||||:....|.      ||:.|..:|:..|..|:|:   ..|...|     ||.:|:||||:
  Rat   175 PRHNSTAVISSQGE------LYAATVIDFSGRDPAIYRS---LGSGPPL-----RTAQYNSKWLN 225

  Fly   252 KPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCS 316
            :||||.:||||.:.|||.||.|||: :||:.||||:|||||.||||:.||...|.|::|||||||
  Rat   226 EPNFVAAFDIGLFAYFFLRENAVEH-DCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCS 289

  Fly   317 ISGEFPFYFNEIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNS 381
            ..||.|||:||:||.:.|| ::...:..|||:.|.:..||||:|:::.|..||||.|:.|.:..:
  Rat   290 RPGEVPFYYNELQSAFHLP-EQDLIYGVFTTNVNSIAASAVCAFNLSAISKAFNGPFRYQENPRA 353

  Fly   382 AWLPVLNSRVPEPRPGTC--VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLV 444
            ||||:.|. :|..:.||.  .....||.:..|...:...||.:||......|...:..:.|:.||
  Rat   354 AWLPIANP-IPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLV 417

  Fly   445 VDKIRI-DILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPN--EAIQVMEISQTR 506
            ||.::. |.|   |.|.|:||..|.|.|.:...........|.::..:.|.  |.::.:.|..:.
  Rat   418 VDLVQAKDTL---YHVLYIGTESGTILKALSTASRSLRGCYLEELHVLPPGRLEPLRSLRILHSA 479

  Fly   507 KSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCRPYELDLLQDVANETSDIC 569
            ::||:|...|:.::.|..|: .|.:...|:  ||||||||.:...|...|
  Rat   480 RALYVGLSDRVLRVPLERCS-AYLSQGACLGARDPYCGWDGKRQLCSTLE--------------- 528

  Fly   570 DSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVT-------WYHHSKDKGRYEIRYSPTKYIET 627
            |||.:...|     |:: ..|.|:        .||       |           ..:.|.::::.
  Rat   529 DSSNMSLWI-----QNI-TACPVR--------NVTRDGGFGPW-----------SPWKPCEHLDG 568

  Fly   628 TERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDAHRCTPPNKSNDYQKIYSDWCHEFEKYKTA 692
            ...|..:......|..|..|   |.|.| ....:....|:....          |        ||
  Rat   569 DNSGSCLCRARSCDSPRPRC---GGLEC-LGPAIHIANCSRNGA----------W--------TA 611

  Fly   693 MKSWEKKQAQCST--------RQNFSSNQHP 715
            ..||    |||||        ||...||..|
  Rat   612 WSSW----AQCSTSCGIGFQVRQRSCSNPAP 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	170/461 (37%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	15/97 (15%)
Sema5b	XP_038944267.1	Sema	60..496	CDD:417757	174/479 (36%)
		PSI	497..544	CDD:396154	18/68 (26%)
		TSP1	609..662	CDD:214559	15/42 (36%)
		TSP1	667..713	CDD:214559
		TSP1	798..850	CDD:214559
		TSP1	855..907	CDD:214559
		TSP_1	911..952	CDD:417691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810