Protein Alignment Sema2a and Sema3e

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001100049.1
• Gene: Sema3e / 296789
• RGDID: 1310973
• Length: 775
• Species: Rattus norvegicus
• Alignment Length: 722
• Identity: 211/722 - (29%)
• Similarity: 332/722 - (45%)
• Gaps: 129/722 - (17%)

  Fly    64 GKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFD 128
            |.|...|..::|.::.|:||..|.|:.:||:.:|..  .|: |....|...|..|:.||| ...:
  Rat    54 GFLDLHTMLLDEYQERLFVGGRDLVYSLNLERVSDG--YRE-IYWPSTAVKVEECIMKGK-DANE 114

  Fly   129 CKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYAN------LTHLP--RSEYVIGVGLGIAKCPY 185
            |.|:|||:...:: ..|..|.|.|.:|....|...      |.||.  |||      .|..:||:
  Rat   115 CANYVRVLHHYNR-THLLTCATGAFDPHCAFIRVGHHSEDPLFHLESHRSE------RGRGRCPF 172

  Fly   186 DPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWL 250
            ||  ||:.:....||.     |::|..:::...|:.|||: |......|.|:..:|.||
  Rat   173 DP--NSSFVSTLVGNE-----LFAGLYSDYWGRDSAIFRS-LGKLGHIRTEHDDERLLK------ 223

  Fly   251 DKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATY 308
             :|.||||:.|.:       .:||||.|.|:|..|....:|:|:.|:|..|:||:.:|.:.|:|:
  Rat   224 -EPKFVGSYMIPDNEDPEDNKMYFFFTEKALEAENNAHTIYTRVGRLCVNDMGGQRILVNKWSTF 287

  Fly   309 LKARLNCSISG--EFPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAA 368
            |||||.||:.|  ....:|:|::.|:.||:...:   .|..|.|::|...|.|||.:|::.|:.|
  Rat   288 LKARLVCSVPGMNGIDTHFDELEDVFLLPTRDPKNPVIFGLFNTTSNIFRGHAVCVYHMSSIREA 352

  Fly   369 FNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVN--------DTSNLPDTVLNFIRSHPLMDKAVN 425
            |||.:..:......| .:...:||.||||:|.:        .|.:.||..:.|.|.||||.:.:.
  Rat   353 FNGPYAHKEGPEYHW-SLYEGKVPYPRPGSCASKVNGGKYGSTKDYPDDAIRFARMHPLMYQPIK 416

  Fly   426 HEHNNPVYYKRDLVFT--KLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRN-----GESLS 483
            ..|..|:..|.|..:.  :|.||  |::..:.:|.|.::||:.|.:.|::..|..     .|.:.
  Rat   417 PVHKKPILVKTDGKYNLRQLAVD--RVEAEDGQYDVLFIGTDTGIVLKVITIYNQETEWMEEVIL 479

  Fly   484 KLLDIF-EVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWD- 544
            :.|.|| :.||   |..||||..|:.||||:...:.|:....|:.....|..|  .|||||.||
  Rat   480 EELQIFKDPAP---IISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDG 541

  Fly   545 --------KEANTCRPYELDLLQDVANETS-----------DICDSSVLKKKIVVTYG---QSVH 587
                    ..|::.|.:.   .|||.:..:           |..|.:..:    :.||   .|..
  Rat   542 ISCSRYYPTGAHSKRRFR---RQDVRHGNAAQQCFGQQFVGDALDRTEER----LAYGIESNSTL 599

  Fly   588 LGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTER------GLVVVSVNEADGGRYD 646
            |.|   .|..|: .:|.|:   ..||| ::|   .:.::|.:|      ||:.:.|.::|.|.|.
  Rat   600 LEC---TPRSLQ-AKVVWF---VQKGR-DVR---KEEVKTDDRVVKMDLGLLFLRVRKSDAGTYF 653

  Fly   647 CHLGGSLLCSY-----NIT---VDAHRCTPP-NKSNDYQKIYSDWCHEFEKYKTAMKSWEKKQAQ 702
            |.   ::..|:     .||   |:.|:.... :|..:.:|.:...|..........|.|.|:..|
  Rat   654 CQ---TVEHSFVHTVRKITLEVVEEHKVEGMFHKDREEEKHHKMPCPPLTGMSQGTKPWYKEFLQ 715

  Fly   703 CSTRQNF 709
            .....||
  Rat   716 LIGYSNF 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	157/492 (32%)
		Ig_Semaphorin_C	573..664	CDD:143180	26/107 (24%)
Sema3e	NP_001100049.1	Sema_3E	49..519	CDD:200514	158/496 (32%)
		PSI	518..566	CDD:214655	15/50 (30%)
		Ig_Semaphorin_classIII	585..675	CDD:143279	26/107 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45857
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910