DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema4g

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_036106.1	Gene:	Sema4g / 26456	MGIID:	1347047	Length:	837	Species:	Mus musculus

Alignment Length:	676	Identity:	197/676 - (29%)
Similarity:	285/676 - (42%)	Gaps:	145/676 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD----VINLEPTRDDVVSC 118
            :|.|......|.|..:.|..:.|.|||...:|.::.::|      ||    .|:.|.:.:....|
Mouse    46 IRHFKGQTQNYSTLLLEEASERLLVGARGALFSLSARDI------RDRTHKEIHWEASPEMQSKC 104

  Fly   119 VSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKC 183
            ..|||:...:|.||||.:|.:: ....|.|||:|..|....|.|....||.|     ...|..||
Mouse   105 HQKGKNNQTECFNHVRFLQRLN-ATHFYACGTHAFQPLCAAIDAETFILPTS-----FEEGKEKC 163

  Fly   184 PYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFK-RTLKYDS 247
            ||||....|.:.::.       |||:.|..||.....:           :|..:... ||.:...
Mouse   164 PYDPARGFTGLIIDG-------GLYTATRYEFRSIPDI-----------RRSRHPHSLRTEEAPM 210

  Fly   248 KWLDKPNFVGSFDIGE----------YVYFFF--RETAVEYINCGKAVY--SRIARVCKKDVGGK 298
            .||:...||.|..:.|          .:||||  ||.........::.:  :|:|||||.|:|||
Mouse   211 HWLNDAEFVFSVLVRESKTSAVGDDDKIYFFFMEREEGSSSFTQSRSSHRVARVARVCKGDLGGK 275

  Fly   299 NLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQLPSDKS---RFFATFTTST--NGLIGSAVC 358
            .:|...|.::|||||.|.|    |.| ..::.|..|.:|.|   .|:|.||.:|  ..|..||:|
Mouse   276 KILQKKWTSFLKARLICHI----PQY-ETLRGVCSLNADTSSHTHFYAVFTLTTQWKTLEASAIC 335

  Fly   359 SFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCV---------NDTSNLPDTVLNFI 414
            .:.:.||||.|.|.|.|.......| ......|||||||:|:         |.:.:||..||:|:
Mouse   336 RYDLAEIQAVFTGPFMEYQDGARRW-GRYEGGVPEPRPGSCITDSLRSRGYNSSQDLPSLVLDFV 399

  Fly   415 RSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIV------ 473
            :.||||.:.|......|:..||::.:|.|....:... ....|.:.::||..|.|:|.|
Mouse   400 KLHPLMARPVVPTRGRPLLLKRNVRYTHLTGTHVSTP-AGPTYDLLFLGTADGWIHKAVVLGSGM 463

  Fly   474 ------QYYRNGESLSKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNC 532
                  |.:|..:|:..|:               ||..:.|||:|....:.|..|:.|: ||.:|
Mouse   464 HIIEEIQVFREPQSVDNLV---------------ISPMQHSLYVGAASGVLQFPLSSCS-RYQSC 512

  Fly   533 FRCV--RDPYCGWDKEANTCRPYELDLLQDVANET---SDI------CDSS-------VLKKKIV 579
            :.|:  ||||||||...:.|.     :...|||.|   .||      |:.|       .||.:.|
Mouse   513 YDCILARDPYCGWDSSIHACM-----VATTVANRTELIQDIERGNRGCEGSRDAGPPPPLKTRSV 572

  Fly   580 VTYGQSVHLGCFVKIPEVLKNEQVTWYHH-----SKDKGRYEIRYSPTKYIETTERGLVVVSVNE 639
            :. |..|.|.|  ..|..|  .:..|..:     |..:..|.:...          ||:|.....
Mouse   573 LR-GDDVLLPC--DQPSNL--ARALWLLNGSKSLSDGQDGYRVGVD----------GLLVTDTQL 622

  Fly   640 ADGGRYDCHLGGS----LLCSYNITV 661
            ...|.|.|:...:    ||.||::||
Mouse   623 EHSGNYGCYAEENGLRMLLASYSLTV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	148/501 (30%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	24/98 (24%)
Sema4g	NP_036106.1	Sema	47..504	CDD:417757	150/508 (30%)
		PSI	505..555	CDD:396154	20/55 (36%)
		Ig_Sema4B_like	565..648	CDD:409456	22/97 (23%)
		Ig strand B	578..582	CDD:409456	2/3 (67%)
		Ig strand C	590..594	CDD:409456	0/3 (0%)
		Ig strand E	613..617	CDD:409456	2/13 (15%)
		Ig strand F	627..632	CDD:409456	2/4 (50%)
		Ig strand G	644..647	CDD:409456	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870