DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and Sema3d

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001098103.1	Gene:	Sema3d / 246262	RGDID:	727939	Length:	777	Species:	Rattus norvegicus

Alignment Length:	744	Identity:	214/744 - (28%)
Similarity:	354/744 - (47%)	Gaps:	136/744 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCK 130
            |.::|..::|:|..|.:||.|.||.:||.::   |.|...|.....::.|..|...||....:|.
  Rat    68 LDFQTLLLDEERGILLLGAKDHVFLLNLVDL---NKNFKKIYWPAAKERVELCKLAGKDANTECA 129

  Fly   131 NHVRVIQSMDQGDRLYVCGTNAHNPK-DYV-IYANLTHLPRSEYVIGVGL-----GIAKCPYDPL 188
            |.:||:|..:: ..:|||||.|.:|. .|: :.||     :.|.:..:.:     |..|||:||.
  Rat   130 NFIRVLQPYNK-THVYVCGTGAFHPLCGYIDLGAN-----KEELIFKLDMQNLESGRLKCPFDPQ 188

  Fly   189 DNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKP 253
            ....::..:.       .|||||.::|...||...|     :.....::.:.||...:..||:..
  Rat   189 QPFASVMTDE-------HLYSGTASDFLGKDTAFTR-----SLGLMQDHHYIRTDISEHYWLNGA 241

  Fly   254 NFVGSFDI-------GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKA 311
            .|:|:|.|       .:.:||||||::.|.....:::.||:.||||.||||:..|.:.|.|:|||
  Rat   242 KFIGTFPIPDTYNPDDDKIYFFFRESSQEGSTSDRSILSRVGRVCKNDVGGQRSLINKWTTFLKA 306

  Fly   312 RLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNG 371
            ||.|||.|.  ...:|:|:|.:|.||:...|   .:..|||:::...|||||.:.:.:|:|.|||
  Rat   307 RLVCSIPGSDGADTHFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNG 371

  Fly   372 KFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVNHEH 428
            .:..:.|::..|:. .:.|:|.||||||        :..|.:.||.|::|||.||:|.|:|....
  Rat   372 PYAHKESADHRWVQ-YDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIRRHPVMYKSVYPVA 435

  Fly   429 NNPVYYKR---DLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKL----L 486
            ..|. :||   |...|::|||.:..:  :.:|.|.::||::|.:.|:|...:...::.::    |
  Rat   436 GAPT-FKRINVDYRLTQIVVDHVVAE--DGQYDVMFLGTDIGTVLKVVSISKEKWNMEEVVLEEL 497

  Fly   487 DIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANT 549
            .:|: .|. ||..||:|..::.||:|:...:.|:.|..|:.....|..|  .|||||.||  .|.
  Rat   498 QVFK-HPT-AILNMELSLKQQQLYVGSWDGLVQLSLHRCDTYGKACADCCLARDPYCAWD--GNA 558

  Fly   550 CRPYE---------------------LDLLQDVANETSDICDSSVLKKKIVVTYG---QSVHLGC 590
            |..|.                     .|:...:::|.:|        :|::  :|   .|..|.|
  Rat   559 CSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHEAAD--------EKVI--FGIEFNSTFLEC 613

  Fly   591 FVKIPEVLKNEQ--VTWY-HHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC----H 648
               ||   |::|  |.|| ..|.|:.|.|::  |.:.|..|:.||::.|:.:.|.|.|.|    |
  Rat   614 ---IP---KSQQASVEWYIQRSGDEHREELK--PDERIIKTDYGLLIRSLQKKDSGIYYCKAQEH 670

  Fly   649 LGGSLLCSYNITVDAHRCTPPNKSNDYQK------------IYSDWCH-------EFEKYKTAMK 694
            .....:....:.|..:.....|:..:||:            .|.|:..       ..::|...|.
  Rat   671 TFIHTIVKLTLNVIENEQMENNQRAEYQEGQVKDLLAESRLRYKDYIQILSSPNFSLDQYCEQMW 735

  Fly   695 SWEKKQAQCSTRQNFSSNQHPNEIFRKPN 723
            ..||::.:   .:..:..:|..|:.:|.|
  Rat   736 YREKRRQR---NKGSAKWKHMQEMKKKRN 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	156/490 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	28/100 (28%)
Sema3d	NP_001098103.1	Sema_3D	61..534	CDD:200513	157/492 (32%)
		PSI	533..570	CDD:214655	13/38 (34%)
		Ig_Sema3	595..686	CDD:409455	29/108 (27%)
		Ig strand B	609..613	CDD:409455	1/3 (33%)
		Ig strand C	621..625	CDD:409455	1/3 (33%)
		Ig strand E	648..652	CDD:409455	2/3 (67%)
		Ig strand F	662..667	CDD:409455	2/4 (50%)
		Ig strand G	679..682	CDD:409455	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11361
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45857
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920