Protein Alignment Sema2a and SEMA3D

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_689967.2
• Gene: SEMA3D / 223117
• HGNCID: 10726
• Length: 777
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 202/648 - (31%)
• Similarity: 319/648 - (49%)
• Gaps: 116/648 - (17%)

  Fly    66 LYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCK 130
            |.::|..::|:|..|.:||.|.:|.::|.::   |.|...|.....::.|..|...||....:|.
Human    68 LDFQTLLLDEERGRLLLGAKDHIFLLSLVDL---NKNFKKIYWPAAKERVELCKLAGKDANTECA 129

  Fly   131 NHVRVIQSMDQGDRLYVCGTNAHNP----------KDYVIYANLTHLPRSEYVIGVGLGIAKCPY 185
            |.:||:|..:: ..:|||||.|.:|          |:.:|:...||...|        |..|||:
Human   130 NFIRVLQPYNK-THIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLES--------GRLKCPF 185

  Fly   186 DPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWL 250
            ||.....::..:.       .|||||.::|...||. |...|..|.    ::.:.||...:..||
Human   186 DPQQPFASVMTDE-------YLYSGTASDFLGKDTA-FTRSLGPTH----DHHYIRTDISEHYWL 238

  Fly   251 DKPNFVGSFDI-------GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATY 308
            :...|:|:|.|       .:.:||||||::.|.....|.:.||:.||||.||||:..|.:.|.|:
Human   239 NGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTF 303

  Fly   309 LKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAA 368
            |||||.|||.|.  ...||:|:|.:|.||:...|   .:..|||:::...|||||.:.:.:|:|.
Human   304 LKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAV 368

  Fly   369 FNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVN 425
            |||.:..:.|::..|:. .:.|:|.||||||        :..|.:.||.|::||:.|.:|.|:|.
Human   369 FNGPYAHKESADHRWVQ-YDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVY 432

  Fly   426 HEHNNPVYYKR---DLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKL-- 485
            .....|. :||   |...|::|||.:..:  :.:|.|.::||::|.:.|:|...:...::.::
Human   433 PVAGGPT-FKRINVDYRLTQIVVDHVIAE--DGQYDVMFLGTDIGTVLKVVSISKEKWNMEEVVL 494

  Fly   486 --LDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKE 546
              |.||:  .:..|..||:|..::.||||:...:.|:.|..|:.....|..|  .|||||.||
Human   495 EELQIFK--HSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWD-- 555

  Fly   547 ANTCRPYE---------------------LDLLQDVANETSDICDSSVLKKKIVVTYG---QSVH 587
            .|.|..|.                     .|:...:::||:|        :|::  :|   .|..
Human   556 GNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETAD--------EKVI--FGIEFNSTF 610

  Fly   588 LGCFVKIPEVLKNEQVT--WY-HHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            |.|   ||   |::|.|  || ..|.|:.|.|::  |.:.|..||.||::.|:.:.|.|.|.|
Human   611 LEC---IP---KSQQATIKWYIQRSGDEHREELK--PDERIIKTEYGLLIRSLQKKDSGMYYC 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	157/493 (32%)
		PSI	527..>550	CDD:396154	10/24 (42%)
		Ig_Semaphorin_C	573..668	CDD:409368	27/81 (33%)
		Ig strand A	573..579	CDD:409368	1/5 (20%)
		Ig strand B	583..591	CDD:409368	3/10 (30%)
		Ig strand C	601..607	CDD:409368	4/8 (50%)
		Ig strand C'	609..612	CDD:409368	1/2 (50%)
		Ig strand D	622..626	CDD:409368	0/3 (0%)
		Ig strand E	630..637	CDD:409368	2/6 (33%)
		Ig strand F	643..652	CDD:409368	3/5 (60%)
		Ig strand G	655..668	CDD:409368
SEMA3D	NP_689967.2	Sema_3D	61..534	CDD:200513	158/495 (32%)
		PSI	533..570	CDD:214655	13/38 (34%)
		Ig_Sema3	595..686	CDD:409455	29/89 (33%)
		Ig strand A	595..601	CDD:409455	3/13 (23%)
		Ig strand B	606..614	CDD:409455	3/10 (30%)
		Ig strand C	620..626	CDD:409455	2/5 (40%)
		Ig strand C'	628..631	CDD:409455	1/2 (50%)
		Ig strand D	641..645	CDD:409455	1/3 (33%)
		Ig strand E	648..655	CDD:409455	2/6 (33%)
		Ig strand F	661..670	CDD:409455	3/5 (60%)
		Ig strand G	673..686	CDD:409455
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777