DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and SEMA3D

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001371829.1	Gene:	SEMA3D / 223117	HGNCID:	10726	Length:	777	Species:	Homo sapiens

Alignment Length:	648	Identity:	202/648 - (31%)
Similarity:	319/648 - (49%)	Gaps:	116/648 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCK 130
            |.::|..::|:|..|.:||.|.:|.::|.::   |.|...|.....::.|..|...||....:|.
Human    68 LDFQTLLLDEERGRLLLGAKDHIFLLSLVDL---NKNFKKIYWPAAKERVELCKLAGKDANTECA 129

  Fly   131 NHVRVIQSMDQGDRLYVCGTNAHNP----------KDYVIYANLTHLPRSEYVIGVGLGIAKCPY 185
            |.:||:|..:: ..:|||||.|.:|          |:.:|:...||...|        |..|||:
Human   130 NFIRVLQPYNK-THIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLES--------GRLKCPF 185

  Fly   186 DPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWL 250
            ||.....::..:.       .|||||.::|...||. |...|..|.    ::.:.||...:..||
Human   186 DPQQPFASVMTDE-------YLYSGTASDFLGKDTA-FTRSLGPTH----DHHYIRTDISEHYWL 238

  Fly   251 DKPNFVGSFDI-------GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATY 308
            :...|:|:|.|       .:.:||||||::.|.....|.:.||:.||||.||||:..|.:.|.|:
Human   239 NGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTF 303

  Fly   309 LKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAA 368
            |||||.|||.|.  ...||:|:|.:|.||:...|   .:..|||:::...|||||.:.:.:|:|.
Human   304 LKARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAV 368

  Fly   369 FNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVN 425
            |||.:..:.|::..|:. .:.|:|.||||||        :..|.:.||.|::||:.|.:|.|:|.
Human   369 FNGPYAHKESADHRWVQ-YDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVY 432

  Fly   426 HEHNNPVYYKR---DLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKL-- 485
            .....|. :||   |...|::|||.:..:  :.:|.|.::||::|.:.|:|...:...::.::
Human   433 PVAGGPT-FKRINVDYRLTQIVVDHVIAE--DGQYDVMFLGTDIGTVLKVVSISKEKWNMEEVVL 494

  Fly   486 --LDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKE 546
              |.||:  .:..|..||:|..::.||||:...:.|:.|..|:.....|..|  .|||||.||
Human   495 EELQIFK--HSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCAWD-- 555

  Fly   547 ANTCRPYE---------------------LDLLQDVANETSDICDSSVLKKKIVVTYG---QSVH 587
            .|.|..|.                     .|:...:::||:|        :|::  :|   .|..
Human   556 GNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETAD--------EKVI--FGIEFNSTF 610

  Fly   588 LGCFVKIPEVLKNEQVT--WY-HHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            |.|   ||   |::|.|  || ..|.|:.|.|::  |.:.|..||.||::.|:.:.|.|.|.|
Human   611 LEC---IP---KSQQATIKWYIQRSGDEHREELK--PDERIIKTEYGLLIRSLQKKDSGMYYC 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	157/493 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	27/81 (33%)
SEMA3D	NP_001371829.1	Sema_3D	61..534	CDD:200513	158/495 (32%)
		PSI	533..570	CDD:214655	13/38 (34%)
		Ig_Sema3	595..686	CDD:409455	29/89 (33%)
		Ig strand B	609..613	CDD:409455	1/3 (33%)
		Ig strand C	621..625	CDD:409455	1/3 (33%)
		Ig strand E	648..652	CDD:409455	2/3 (67%)
		Ig strand F	662..667	CDD:409455	2/4 (50%)
		Ig strand G	679..682	CDD:409455
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11345
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920