DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema6d

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_006499174.1	Gene:	Sema6d / 214968	MGIID:	2387661	Length:	1086	Species:	Mus musculus

Alignment Length:	762	Identity:	228/762 - (29%)
Similarity:	350/762 - (45%)	Gaps:	181/762 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLALLLLLCSSVSETAADYE-NTWNFYYER--PCCTGNDQGNNNYGKHGADHVREFNCGKLYYRT 70
            :|.||:....:||....|.. ||.:::|.|  |...|...||.      :.|..:|..
Mouse    10 VLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNE------SQHRLDFQL------- 61

  Fly    71 FHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTR--------DDVVSCVSKGKSQIF 127
              |.:.|||||:...|:|:.|||..|..:    :||   |::        .|..:|..|||.: .
Mouse    62 --MLKIRDTLYIAGRDQVYTVNLNEIPQT----EVI---PSKKLTWRSRQQDRENCAMKGKHK-D 116

  Fly   128 DCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDNST 192
            :|.|.::|....:. :.::||||||.||  ...|..|..|   ||......|:|:||:|....:.
Mouse   117 ECHNFIKVFVPRND-EMVFVCGTNAFNP--MCRYYRLRTL---EYDGEEISGLARCPFDARQTNV 175

  Fly   193 AIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVG 257
            |::.:.       .|||.|.|:|..:|.||:|: :.:.||       .||:||||||:.:|:|:.
Mouse   176 ALFADG-------KLYSATVADFLASDAVIYRS-MGDGSA-------LRTIKYDSKWIKEPHFLH 225

  Fly   258 SFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGG-KNLLAHNWATYLKARLNCSISGEF 321
            :.:.|.||||||||.|||:.|.|||||||:||:||.|:|| :.:|..:|.::||||||||:.|:.
Mouse   226 AIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDS 290

  Fly   322 PFYFNEIQSVYQ------LPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSN 380
            .|||:.:||:..      :|:    ....|||..|.:.|||||:|.:::|:..|.|:||||.:.:
Mouse   291 FFYFDVLQSITDIIQINGIPT----VVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351

  Fly   381 SAWLPVLNSRVPEPRPGTCVN-------DTS-NLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRD 437
            |.|..|...:||:||||.|..       .|| :.||..|.||:||||||.||....:.|.:.|..
Mouse   352 SVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTR 416

  Fly   438 LVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIV----QYYRNGESLSKLLDIFEVAPNEA-- 496
            :.:....::..|.....|.|.|.:||:..|.:.|::    .:..|...|.:.::.:..|...|
Mouse   417 VRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAES 481

  Fly   497 -----IQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFR-CV--RDPYCGWDKEANTCRPY 553
                 :..:::.:...:||:.....:.:|.|:.| .||.:|.: |:  |||||||..:.
Mouse   482 EEDRKVVSLQLDKDHHALYVAFSSCVVRIPLSRC-ERYGSCKKSCIASRDPYCGWLSQG------ 539

  Fly   554 ELDLLQDVANETSDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIR 618
                          :|:.        ||.|.            :|..|....:|:
Mouse   540 --------------VCER--------VTLGM------------LLLTEDFFAFHN---------- 560

  Fly   619 YSPTKYIETTERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDAHRCTPPNKSNDYQKIYSDWC 683
            :||..|.:.||.|      |.|       |||           |.|...||:.:.|| ||:....
Mouse   561 HSPGGYEQDTEYG------NTA-------HLG-----------DCHESLPPSTTPDY-KIFGGPT 600

  Fly   684 HEFEKYKTA--------------MKSWEKKQAQCSTRQNFSSNQHPN 716
            .:.|...::              :.:|..|   .::.:.|.....||
Mouse   601 SDMEVSSSSVTTVASSPEITSKVIDTWRPK---LTSSRKFVVQDDPN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	167/490 (34%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	18/90 (20%)
Sema6d	XP_006499174.1	Sema	49..513	CDD:417757	171/511 (33%)
		PSI	514..>543	CDD:396154	13/49 (27%)
		PHA03247	<922..1069	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910