DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema6b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001123928.1	Gene:	Sema6b / 20359	MGIID:	1202889	Length:	886	Species:	Mus musculus

Alignment Length:	670	Identity:	203/670 - (30%)
Similarity:	323/670 - (48%)	Gaps:	128/670 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PLLALLLLLCSSV------------SETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVRE 60
            |.|:..|||...|            |....||.:.:      |...|:..|...    .|:...:
Mouse    11 PALSFFLLLLLGVTYGLFPEEPPPLSVAPRDYLSHY------PVFVGSGPGRLT----AAEGAED 65

  Fly    61 FNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCN-RDVINLEPTRDDVVSCVSKGKS 124
            .|    ..|...:|.   ||::|..|.:::|.|:..:|:... :..:.......|:..|..|||
Mouse    66 LN----IQRVLRVNR---TLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGK- 122

  Fly   125 QIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGL-GIAKCPYDPL 188
            |..:|:|.|:|:...|: ..|:|||:||.||    |.||  :...:..::|..: |:|:|||||.
Mouse   123 QEGECRNFVKVLLLRDE-STLFVCGSNAFNP----ICAN--YSMDTLQLLGDSISGMARCPYDPK 180

  Fly   189 DNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKP 253
            ..:.|::.:     |:  |::.|..:|...|.||:|:        ..:....||:|:||||..:|
Mouse   181 HANVALFSD-----GM--LFTATVTDFLAIDAVIYRS--------LGDRPTLRTVKHDSKWFKEP 230

  Fly   254 NFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGK-NLLAHNWATYLKARLNCSI 317
            .||.:.:.|.:|||||||.|:|:....|.|.||:|||||.||||. .:|...|.::||||||||:
Mouse   231 YFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSV 295

  Fly   318 SGEFPFYFNEIQSVYQLPSDKSR--FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSN 380
            .|:..||||.:|:|..:.|...|  ..|.|:|.:|.:.|||||:|.:|::.|.|.|:|:||.|..
Mouse   296 PGDSHFYFNVLQAVTGVVSLGGRPVILAVFSTPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPE 360

  Fly   381 SAWLPVLNSRVPEPRPGTCV------NDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLV 439
            |.|.||...:||.||||.|.      |.:|.|||.:|||:::|||||:||....::| :..|.|:
Mouse   361 SIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDEILNFVKTHPLMDEAVPSLGHSP-WIVRTLM 424

  Fly   440 FTKLVVDKIRIDI-----LNQEYIVYYVGTNLGRIYKIVQYYRNGESLSK------LLDIFEV-- 491
            ..:|.  ::.:|:     .||  .:.::|:..|.:.|.:  .:...|:|.      .|:.||.
Mouse   425 RHQLT--RVAVDVGAGPWGNQ--TIVFLGSEAGTVLKFL--VKPNASVSGTTGPSIFLEEFETYR 483

  Fly   492 -----APNEA------IQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFR-CV--RDPYCG 542
                 .|:.|      :..:|:......|.......:.::.:|.| :.|..|.: |:  :|||||
Mouse   484 PDRCGRPSSAGEWGQRLLSLELDAASGGLLAAFPRCVVRVPVARC-QLYSGCMKNCIGSQDPYCG 547

  Fly   543 WDKEAN-------TCRPYELDLLQDVAN-ETSDICD-------------SSVLKKKIVVTYGQSV 586
            |..:.:       |...:|    |||:. .||.:.|             :.::...::||..
Mouse   548 WAPDGSCIFLRPGTSATFE----QDVSGASTSGLGDCTGLLRASLSDDRAGLVSVNLLVTSS--- 605

  Fly   587 HLGCFVKIPEVLKNEQVTWY 606
             :..|| :..|:....|.|:
Mouse   606 -VAAFV-VGAVVSGFSVGWF 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	163/491 (33%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	7/34 (21%)
Sema6b	NP_001123928.1	Sema_6B	58..526	CDD:200528	165/508 (32%)
		PSI	527..573	CDD:214655	15/50 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..731
		PHA03269	708..>875	CDD:165527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910