DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema4f

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_035480.3	Gene:	Sema4f / 20355	MGIID:	1340055	Length:	777	Species:	Mus musculus

Alignment Length:	732	Identity:	193/732 - (26%)
Similarity:	308/732 - (42%)	Gaps:	157/732 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SPLLALLLLLCS---------SVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFN 62
            |.||.|||.:.|         ||..|:...                .:.::...:..|.|.  :|
Mouse    24 SSLLLLLLAMLSAPVCGRVPRSVPRTSLPI----------------SEADSYLTRFAAPHT--YN 70

  Fly    63 CGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIF 127
                 |....::....||||||.|.:|.:.|..........|.:..|..|.   :|..|||.: .
Mouse    71 -----YSALLVDPASHTLYVGARDSIFALTLPFSGEKPRRIDWMVPETHRQ---NCRKKGKKE-D 126

  Fly   128 DCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVI-YANLTHLPRSEYVIGVGLGIAKCPYDPLDNS 191
            :|.|.:::: ::.....|..|||.|.:||..|| .::...:.|.|      .|..|||::|...|
Mouse   127 ECHNFIQIL-AIANASHLLTCGTFAFDPKCGVIDVSSFQQVERLE------SGRGKCPFEPAQRS 184

  Fly   192 TAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRT-----DLYNTSAKRLEYKFKRTLKYDSKWLD 251
            .|:..     ||:  ||:.|...|...:.:|.|.     |...|          .||   |.||:
Mouse   185 AAVMA-----GGV--LYTATVKNFLGTEPIISRAVGRAEDWIRT----------ETL---SSWLN 229

  Fly   252 KPNFV----------GSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWA 306
            .|.||          |..|..:.::|||.||:....:..:....|:||||..|:||:..|...|.
Mouse   230 APAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVARVCAGDLGGRKTLQQRWT 294

  Fly   307 TYLKARLNC------SISGEFPFYFNEIQSVYQLPSDKSR----FFATFTTSTNGLIGSAVCSFH 361
            |:|||.|.|      ..||       .:|.:.:|......    |:..|::...|...||||:|.
Mouse   295 TFLKADLLCPGPEHGRASG-------VLQDMTELRPQPGAGTPLFYGIFSSQWEGAAISAVCAFR 352

  Fly   362 INEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVND---------TSNLPDTVLNFIRSH 417
            ..:|:|..||.|:|.....:..|||:::.||:||||.|:.:         :.:|||.||.|||.|
Mouse   353 PQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECITNNMKFQQFGSSLSLPDRVLTFIRDH 417

  Fly   418 PLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESL 482
            ||||:.|......|:....|..:.::|..:: ..:..:||.|.|:||..|.:::.|   |.|..|
Mouse   418 PLMDRPVFPADGRPLLVTTDTAYLRVVAHRV-TSLSGKEYDVLYLGTEDGHLHRAV---RIGAQL 478

  Fly   483 SKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDK 545
            |.|.|:......:.::.|::  ....|.:|:...:.|::.:.|. |..:|..|:  :||.|.|..
Mouse   479 SVLEDLALFPETQPVESMKL--YHDWLLVGSHTEVTQVNTSNCG-RLQSCSECILAQDPVCAWSF 540

  Fly   546 EANTCRPY---ELDLLQDVAN-ETSDIC-----DSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNE 601
            ..:.|..:   ...::||:.: :.|.:|     :..|:.:..|.|.|..| |.|         :.
Mouse   541 RLDACVAHAGEHRGMVQDIESADVSSLCPKEPGEHPVVFEVPVATVGHVV-LPC---------SP 595

  Fly   602 QVTW----YHHSKDKGRYEIRYSPTKYIETTER--GLVVVSVNEADGGRY--DCHLGGS--LLCS 656
            ...|    :|            .|:.....|.|  ||.|| |.....|.|  :|..||:  ::.:
Mouse   596 SSAWASCVWH------------QPSGVTSLTPRRDGLEVV-VTPGAMGAYACECQEGGAARVVAA 647

  Fly   657 YNITVDAHRCTPPNKSN 673
            |::...:.| .|.|:::
Mouse   648 YSLVWGSQR-GPANRAH 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	141/491 (29%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	23/100 (23%)
Sema4f	NP_035480.3	Sema_4F	58..517	CDD:200522	144/509 (28%)
		PSI	518..569	CDD:279745	12/51 (24%)
		Ig	576..655	CDD:299845	23/101 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..742
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11483650	775..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910