DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2a and Sema4d

DIOPT Version :9

Sequence 1:NP_477507.1 Gene:Sema2a / 36846 FlyBaseID:FBgn0011260 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_001268809.1 Gene:Sema4d / 20354 MGIID:109244 Length:861 Species:Mus musculus


Alignment Length:726 Identity:221/726 - (30%)
Similarity:340/726 - (46%) Gaps:139/726 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFN-CGKLYYRTFHM 73
            |||:::|.::|: .|.....||                    :||...:.:|: .|...|....|
Mouse    12 LALVVVLRTAVA-FAPVPRLTW--------------------EHGEVGLVQFHKPGIFNYSALLM 55

  Fly    74 NEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQS 138
            :||:|||||||.:.||.||..|||.   .:..:..:.:.|....|..||||:..:|.|::||:|.
Mouse    56 SEDKDTLYVGAREAVFAVNALNISE---KQHEVYWKVSEDKKSKCAEKGKSKQTECLNYIRVLQP 117

  Fly   139 MDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDNSTAIYVENGNPG 202
            : ....||||||||..|. |::...:...|.:||.      |..:||:||..:.|::.|     |
Mouse   118 L-SSTSLYVCGTNAFQPTCDHLNLTSFKFLGKSED------GKGRCPFDPAHSYTSVMV-----G 170

  Fly   203 GLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFV----------G 257
            |  .|||||:..|..::.:|.|...:  |..|.||..        .||::|:||          |
Mouse   171 G--ELYSGTSYNFLGSEPIISRNSSH--SPLRTEYAI--------PWLNEPSFVFADVIQKSPDG 223

  Fly   258 SFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGEFP 322
            .....:.|||||.|.:|||....|.:..|:|||||.|.||...|...|.::|||||.|| ..:..
Mouse   224 PEGEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGGLRTLQKKWTSFLKARLICS-KPDSG 287

  Fly   323 FYFNEIQSVYQL--PSDKSR-FFATFTTSTNGLIGSAVCSFHINEIQAAFN-GKFKEQSS---SN 380
            ..||.:|.|:.|  |..|.. |:|.||...|.:..||||::.:..::|.|: ||:.:.::   |:
Mouse   288 LVFNILQDVFVLRAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLATVEAVFSRGKYMQSATVEQSH 352

  Fly   381 SAWLPVLNSRVPEPRPGTCV-------NDTS--NLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKR 436
            :.|:. .|..||.||||.|:       |.||  ||||..|.|::.|||||.:|....|.|...|:
Mouse   353 TKWVR-YNGPVPTPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPKLIKK 416

  Fly   437 DLVFTKLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIV------------QYYRNGESLSKLLDI 488
            |:.:|::|||:.: :|  ...|.|.::.|:.|.::|.|            |.:|:.|.:..||  
Mouse   417 DVNYTQIVVDRTQALD--GTFYDVMFISTDRGALHKAVILTKEVHVIEETQLFRDSEPVLTLL-- 477

  Fly   489 FEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCR 551
                       :...:.||.:|.|::..:.|..||.| .::.:|..||  |||||.|......|.
Mouse   478 -----------LSSKKGRKFVYAGSNSGVVQAPLAFC-EKHGSCEDCVLARDPYCAWSPAIKACV 530

  Fly   552 PYELD------LLQDVANETSDICDSSVLKKKI---VVTYGQSVHLGCFVKIPEVLKN-EQVTWY 606
            ....:      .:||::.:||...|.|  |:..   ...:|.:..|.||.|     .| .:|.|.
Mouse   531 TLHQEEASSRGWIQDMSGDTSSCLDKS--KESFNQHFFKHGGTAELKCFQK-----SNLARVVWK 588

  Fly   607 HHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC--------HLGGSLLCSYNITVDA 663
            ..:.     |::.:..||.....:.|::.::::.|.|.|.|        .....||..:.:.|..
Mouse   589 FQNG-----ELKAASPKYGFVGRKHLLIFNLSDGDSGVYQCLSEERVRNKTVSQLLAKHVLEVKM 648

  Fly   664 HRCTPPNKSND 674
            ...|||:.:::
Mouse   649 VPRTPPSPTSE 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2aNP_477507.1 Sema_2A 66..523 CDD:200499 167/496 (34%)
Ig_Semaphorin_C 573..664 CDD:143180 20/102 (20%)
Sema4dNP_001268809.1 Sema_4D 31..501 CDD:200520 173/533 (32%)
PSI 503..548 CDD:396154 13/45 (29%)
Ig 563..646 CDD:416386 18/92 (20%)
Ig strand B 569..577 CDD:409353 2/7 (29%)
Ig strand C 583..589 CDD:409353 2/5 (40%)
Ig strand C' 591..594 CDD:409353 0/7 (0%)
Ig strand D 600..604 CDD:409353 2/3 (67%)
Ig strand E 607..614 CDD:409353 1/6 (17%)
Ig strand F 620..629 CDD:409353 3/8 (38%)
Ig strand G 633..646 CDD:409353 2/12 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..709 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 793..839
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
54.870

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