DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema4b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001347064.1	Gene:	Sema4b / 20352	MGIID:	107559	Length:	823	Species:	Mus musculus

Alignment Length:	648	Identity:	189/648 - (29%)
Similarity:	291/648 - (44%)	Gaps:	148/648 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLQLSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADH--VREFNCG 64
            ::|:.:.||.|||||..:.:..|.                    |.......|::.  :|:|...
Mouse     8 AVLRRALLLLLLLLLLRTTTTRAL--------------------GPRISVPLGSEERLIRKFEAE 52

  Fly    65 KL-YYRTFHMNEDRDTLYVGAMDRVFRVNLQNIS------------SSNCNRDVINLEPTRDDVV 116
            .: .|....:::|..||||||.:.:|.:| .|:|            |::.:|.           .
Mouse    53 NISNYTALLLSQDGKTLYVGAREALFALN-SNLSFLPGGEYQELLWSADADRK-----------Q 105

  Fly   117 SCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSE---YVIGVG 177
            .|..|||....||:|:::::..:: ...|..|||.|.:|. .|:..|:.| |.:.|   .::..|
Mouse   106 QCSFKGKDPKRDCQNYIKILLPLN-SSHLLTCGTAAFSPLCAYIHIASFT-LAQDEAGNVILEDG 168

  Fly   178 LGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRT 242
            .|  :||:||...|||:.|:.       .||:||.:.|...|..|.|:            :..|.
Mouse   169 KG--RCPFDPNFKSTALVVDG-------ELYTGTVSSFQGNDPAISRS------------QSSRP 212

  Fly   243 LKYDS--KWLDKPNFVGSFDIGE----------YVYFFFRETAVEYINCGKAVYSRIARVCKKDV 295
            .|.:|  .||..|.||.|..:.|          .:||||.||..|:......:.||:|||||.|.
Mouse   213 TKTESSLNWLQDPAFVASAYVPESLGSPIGDDDKIYFFFSETGQEFEFFENTIVSRVARVCKGDE 277

  Fly   296 GGKNLLAHNWATYLKARLNCSISGE-FPFYFNEIQSVYQL---PSD--KSRFFATFTT-----ST 349
            ||:.:|...|.::|||:|.||...: ||  ||.:|.|:.|   |.|  |:.|:..||:     :|
Mouse   278 GGERVLQQRWTSFLKAQLLCSRPDDGFP--FNVLQDVFTLNPNPQDWRKTLFYGVFTSQWHRGTT 340

  Fly   350 NGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC---------VNDTSN 405
            .   |||:|.|.:|::|.||:|.:|:.:.....|....: :||.||||.|         :|.:..
Mouse   341 E---GSAICVFTMNDVQKAFDGLYKKVNRETQQWYTETH-QVPTPRPGACITNSARERKINSSLQ 401

  Fly   406 LPDTVLNFIRSHPLMDKAVNHE---HNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLG 467
            |||.||||::.|.|||..|...   ......|:|..|.        |:..|:..|.|.::||..|
Mouse   402 LPDRVLNFLKDHFLMDGQVRSRLLLLQPRARYQRVAVH--------RVPGLHSTYDVLFLGTGDG 458

  Fly   468 RIYKIVQYYRNGESLSKLLDIFE---VAP-NEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRR 528
            |::|.|       :||..:.|.|   :.| .:.:|.:.:......||..:...:.|:.:|.|: .
Mouse   459 RLHKAV-------TLSSRVHIIEELQIFPQGQPVQNLLLDSHGGLLYASSHSGVVQVPVANCS-L 515

  Fly   529 YDNCFRCV--RDPYCGWDKEANTCR---PYELDL-----LQDVAN-ETSDICDSSVLKKKIVV 580
            |..|..|:  |||||.|...|  ||   .|:.||     .||:.. ...::|.:|..|.:.:|
Mouse   516 YPTCGDCLLARDPYCAWTGSA--CRLASLYQPDLASRPWTQDIEGASVKELCKNSSYKARFLV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	153/512 (30%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	2/8 (25%)
Sema4b	NP_001347064.1	Sema	48..511	CDD:417757	154/518 (30%)
		PSI	512..558	CDD:396154	18/48 (38%)
		Ig_Sema4B_like	579..663	CDD:409456
		Ig strand B	592..596	CDD:409456
		Ig strand C	604..608	CDD:409456
		Ig strand E	626..629	CDD:409456
		Ig strand F	639..644	CDD:409456
		Ig strand G	656..659	CDD:409456
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910