DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and Sema4a

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_006501250.1	Gene:	Sema4a / 20351	MGIID:	107560	Length:	798	Species:	Mus musculus

Alignment Length:	698	Identity:	199/698 - (28%)
Similarity:	323/698 - (46%)	Gaps:	115/698 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALLLLLCSSVSETAADY-----------ENTWN----FYYE-------RPCCTGNDQGNNNYGK- 52
            |.|.|..:.:.|.:.|:           :::|:    |:::       .|......||.....|
Mouse    18 ACLCLPSTGIKEPSGDHLRLTMALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKY 82

  Fly    53 HGADHVREFNC----GKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRD 113
            |..|..|..:.    |...:.|..:::|.:||||||.:.|..:|:||...... :::|....:..
Mouse    83 HAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRL-KNMIPWPASER 146

  Fly   114 DVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVG 177
            ....|..|.||....|.|.:||:.|.: ...||.|||.|.:|. .::...:...||  ..:..|.
Mouse   147 KKTECAFKKKSNETQCFNFIRVLVSYN-ATHLYACGTFAFSPACTFIELQDSLLLP--ILIDKVM 208

  Fly   178 LGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRT 242
            .|..:.|:||:...||:.|:     |:  |||||...|..::.::.||           ...:..
Mouse   209 DGKGQSPFDPVHKHTAVLVD-----GM--LYSGTMNNFLGSEPILMRT-----------LGSQPV 255

  Fly   243 LKYD--SKWLD-KPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHN 304
            ||.|  .:||. ..:||.:....:.|||||.|||.|:....:...||:|:|||.||||:.||...
Mouse   256 LKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKK 320

  Fly   305 WATYLKARLNCSISGEFPFYFNEIQSVYQLPSDK---SRFFATFTT--STNGLIGSAVCSFHINE 364
            |.|:|||:|.|:..|:.|  ||.|:....||:|.   ||.:|.||:  ...|...||||:|.:.:
Mouse   321 WTTFLKAQLLCAQPGQLP--FNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTD 383

  Fly   365 IQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHN 429
            |:..|.||:||.:...|.|.....|.| .||||:|....|:  |..|.|::.|.|||:   |...
Mouse   384 IERVFKGKYKELNKETSRWTTYRGSEV-SPRPGSCSMGPSS--DKALTFMKDHFLMDE---HVVG 442

  Fly   430 NPVYYKRDLVFTKLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAP 493
            .|:..|..:.:|:|.|:..| :|  ...::|.|:||:.|.::|.|.   ..:|.:.|::..:::|
Mouse   443 TPLLVKSGVEYTRLAVESARGLD--GSSHVVMYLGTSTGSLHKAVV---PQDSSAYLVEEIQLSP 502

  Fly   494 -NEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTC----- 550
             :|.::.::::..:.:::.|....|.::..|.|: .|::|..||  |||:|.||.|:..|
Mouse   503 DSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCS-VYESCVDCVLARDPHCAWDPESRLCSLLSG 566

  Fly   551 --RPYELDLLQDVANETSD-ICDSSVLKK-----------KIVVTYGQSV-HLGCFVKIPEVLKN 600
              :|::    ||:.....: :|....:.:           |.|:|...|: .|.|    |.:...
Mouse   567 STKPWK----QDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPC----PHLSAL 623

  Fly   601 EQVTWYHHSKDKGRYEI-RYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            ....|.|     ||.:| ..|.|.|     .|.:::...:..||.|.|
Mouse   624 ASYHWSH-----GRAKISEASATVY-----NGSLLLLPQDGVGGLYQC 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	146/467 (31%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	20/88 (23%)
Sema4a	XP_006501250.1	Sema	93..533	CDD:387663	147/474 (31%)
		PSI	534..578	CDD:214655	16/48 (33%)
		Ig	603..675	CDD:386229	20/73 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870