Protein Alignment Sema2a and Sema3f

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001391952.1
• Gene: Sema3f / 20350
• MGIID: 1096347
• Length: 820
• Species: Mus musculus
• Alignment Length: 737
• Identity: 213/737 - (28%)
• Similarity: 322/737 - (43%)
• Gaps: 162/737 - (21%)

  Fly    54 GADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVV 116
            |..|...|......||....:||.|.:|||:.|.|..::|.:|     ||:  :|:...:...:.
Mouse    43 GTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDI-----NREPLIIHWAASPQRIE 102

  Fly   117 SCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYAN---------LTHL----- 167
            .|:..||....:|.|.||:||..:: ..||||||.|:||  ...|.|         .|.:
Mouse   103 ECILSGKDGNGECGNFVRLIQPWNR-THLYVCGTGAYNP--MCTYVNRGRRAQALPWTQMQVVRG 164

  Fly   168 ----------------PRSEYVI-----GVGLGIAKCPYDP-LDNSTAIYVENGNPGGLPGLYSG 210
                            ||.:|:.     .:..|..|||||| ||.::|:..|.        ||:|
Mouse   165 RGSRATDGADRPTPTAPRQDYIFYLEPEKLESGKGKCPYDPKLDTASALINEE--------LYAG 221

  Fly   211 TNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDI-------GEYVYFF 268
            ...:|...|..||||....|:        .||.:|:|:||:.|:|:.:..|       .:.:|||
Mouse   222 VYIDFMGTDAAIFRTLGKQTA--------MRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFF 278

  Fly   269 FRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE--FPFYFNEIQSV 331
            |||.:.|... ..|||:||.|:|..|.||...|.:.|:|:|||||.||:.||  ...:|:|:|.|
Mouse   279 FRERSAEAPQ-NPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDV 342

  Fly   332 YQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPE 393
            :...:...|   .:|.||:|.:...|||||.:.:.:|:..|||.|..:...|..|:| .:.::|.
Mouse   343 FVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPY 406

  Fly   394 PRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVF--TKLVVDKI 448
            ||||||        :..|.:.||.|:||:|:||||.:||......|:..:....:  |.:.||
Mouse   407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTVAVD-- 469

  Fly   449 RIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLL----DIF-EVAPNEAIQVMEISQTRKS 508
            ::|..:..|.|.::||:.|.:.|::...::.:.:.:|:    ::| |.||   ::.|.||..|:.
Mouse   470 QVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAP---VKTMTISSKRQQ 531

  Fly   509 LYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPY-----ELDLLQDV----- 561
            ||:.:...:..:.|..|......|..|  .|||||.||.:|  |..|     .....|||
Mouse   532 LYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQA--CSRYTASSKRRSRRQDVRHGNP 594

  Fly   562 --------ANETSDICDSSVLKKKIVVTY---GQSVHLGCFVKIPEVLKNEQVTW-YHHSKDKGR 614
                    :|...:..:|        |.|   |.:..|.|..:.|:.    .|.| :.......|
Mouse   595 IRQCRGFNSNANKNAVES--------VQYGVAGSAAFLECQPRSPQA----TVKWLFQRDPSDRR 647

  Fly   615 YEIR---YSPTKYIETTERGLV--------------------VVSVNEADGGRYDCHLGGSLLCS 656
            .|:.   .||..  ..|.||..                    |.|:.:...|  :...||||...
Mouse   648 REVSSCVLSPPP--TPTPRGYAAPWIWEFFYSGESLREKCTSVASLGQPSTG--EAKAGGSLEFK 708

  Fly   657 YNITVDA-HRCTPPNKSNDYQK 677
            .::...| .|.|||....:.||
Mouse   709 ASLVYRASSRSTPPGLPRETQK 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	162/521 (31%)
		PSI	527..>550	CDD:396154	10/24 (42%)
		Ig_Semaphorin_C	573..668	CDD:409368	24/122 (20%)
		Ig strand A	573..579	CDD:409368	0/5 (0%)
		Ig strand B	583..591	CDD:409368	2/7 (29%)
		Ig strand C	601..607	CDD:409368	2/6 (33%)
		Ig strand C'	609..612	CDD:409368	0/2 (0%)
		Ig strand D	622..626	CDD:409368	0/3 (0%)
		Ig strand E	630..637	CDD:409368	3/26 (12%)
		Ig strand F	643..652	CDD:409368	2/8 (25%)
		Ig strand G	655..668	CDD:409368	2/13 (15%)
Sema3f	NP_001391952.1	Sema_3F	48..548	CDD:200515	164/530 (31%)
		PSI	547..584	CDD:214655	13/38 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..602		3/18 (17%)
		Ig	608..>652	CDD:472250	11/55 (20%)
		Ig strand B	622..626	CDD:409455	1/3 (33%)
		Ig strand C	634..638	CDD:409455	1/3 (33%)