DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema3e

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_035478.2	Gene:	Sema3e / 20349	MGIID:	1340034	Length:	775	Species:	Mus musculus

Alignment Length:	756	Identity:	214/756 - (28%)
Similarity:	336/756 - (44%)	Gaps:	141/756 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TGNDQGNNNYGKHGADH--VREFN--------CGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQN 95
            |.....|.:|.:....|  :.|.|        .|.|...|..::|.::.|:||..|.|:.:||:.
Mouse    21 TPGHSANPSYPRLRLSHKELLELNRTSIFQSPLGFLDLHTMLLDEYQERLFVGGRDLVYSLNLER 85

  Fly    96 ISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVI 160
            :|..  .|: |....|...|..|:.||| ...:|.|::||:...:: ..|..|.|.|.:|....|
Mouse    86 VSDG--YRE-IYWPSTAVKVEECIMKGK-DANECANYIRVLHHYNR-THLLTCATGAFDPHCAFI 145

  Fly   161 YAN------LTHLP--RSEYVIGVGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTK 217
            ...      |.||.  |||      .|..:||:||  ||:.:....||.     |::|..:::..
Mouse   146 RVGHHSEEPLFHLESHRSE------RGRGRCPFDP--NSSFVSTLVGNE-----LFAGLYSDYWG 197

  Fly   218 ADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGE-------YVYFFFRETAVE 275
            .|:.|||      |..:|.:  .||...|.:.|.:|.||||:.|.:       .:||||.|.|:|
Mouse   198 RDSAIFR------SMGKLGH--IRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKMYFFFTEKALE 254

  Fly   276 YINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISG--EFPFYFNEIQSVYQLPSDK 338
            ..|....:|:|:.|:|..|:||:.:|.:.|:|:|||||.||:.|  ....||:|::.|:.||:..
Mouse   255 AENNAHTIYTRVGRLCVNDMGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRD 319

  Fly   339 SR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCV 400
            .:   .|..|.|::|...|.|||.:|::.|:.||||.:..:......| .:...:||.||||:|.
Mouse   320 PKNPVIFGLFNTTSNIFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHW-SLYEGKVPYPRPGSCA 383

  Fly   401 N--------DTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFT--KLVVDKIRIDILNQ 455
            :        .|.:.||..:.|.|.||||.:.:...|..|:..|.|..:.  :|.||  |::..:.
Mouse   384 SKVNGGKYGTTKDYPDDAIRFARMHPLMYQPIKPVHKKPILVKTDGKYNLRQLAVD--RVEAEDG 446

  Fly   456 EYIVYYVGTNLGRIYKIVQYYRN-----GESLSKLLDIF-EVAPNEAIQVMEISQTRKSLYIGTD 514
            :|.|.::||:.|.:.|::..|..     .|.:.:.|.|| :.||   |..||||..|:.||||:.
Mouse   447 QYDVLFIGTDTGIVLKVITIYNQETEWMEEVILEELQIFKDPAP---IISMEISSKRQQLYIGSA 508

  Fly   515 HRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPY--------ELDLLQDVANETS--- 566
            ..:.|:....|:.....|..|  .|||||.||  ..:|..|        .....|||.:..:
Mouse   509 SAVAQVRFHHCDMYGSACADCCLARDPYCAWD--GISCSRYYPTGAHAKRRFRRQDVRHGNAAQQ 571

  Fly   567 --------DICDSSVLKKKIVVTYG---QSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYS 620
                    |..|.:..:    :.||   .|..|.|   .|..|: .:|.|:   ..||| ::|
Mouse   572 CFGQQFVGDALDRTEER----LAYGIESNSTLLEC---TPRSLQ-AKVIWF---VQKGR-DVR-- 622

  Fly   621 PTKYIETTER------GLVVVSVNEADGGRYDCHLGGSLLCSYNI----------TVDAHRCTPP 669
             .:.::|.:|      ||:.:.|.::|.|.|.|.     ...:|.          .|:.|:....
Mouse   623 -KEEVKTDDRVVKMDLGLLFLRVRKSDAGTYFCQ-----TVEHNFVHTVRKITLEVVEEHKVEGM 681

  Fly   670 -NKSNDYQKIYSDWCHEFEKYKTAMKSWEKKQAQCSTRQNF 709
             :|.::.::.:...|..........|.|.|:..|.....||
Mouse   682 FHKDHEEERHHKMPCPPLSGMSQGTKPWYKEFLQLIGYSNF 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	157/492 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	24/109 (22%)
Sema3e	NP_035478.2	Sema_3E	49..519	CDD:200514	158/501 (32%)
		PSI	518..566	CDD:214655	15/49 (31%)
		Ig_Semaphorin_classIII	585..675	CDD:143279	24/109 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910