DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and Sema3c

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_038685.3	Gene:	Sema3c / 20348	MGIID:	107557	Length:	751	Species:	Mus musculus

Alignment Length:	664	Identity:	199/664 - (29%)
Similarity:	305/664 - (45%)	Gaps:	126/664 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DHVREFNCGKLY--------YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEP-- 110
            |.:||....:.:        ||...|:||:|.:|||:.|.:..:|:.|||.          ||
Mouse    34 DELRETKTSEYFSLSHQQLDYRILLMDEDQDRIYVGSKDHILSLNINNISQ----------EPLS 88

  Fly   111 -----TRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRS 170
                 :...|..|...||.....|.|.|||||:.:: ..|||||:.|.:|    :...|....||
Mouse    89 VFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNR-THLYVCGSGAFSP----VCTYLNRGRRS 148

  Fly   171 E---YVIG--VGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNT 230
            |   ::|.  ...|..:|.::|..|:.::.:..       .|:||...:|...|..|||     :
Mouse   149 EDQVFMIDSKCESGKGRCSFNPNVNTVSVMINE-------ELFSGMYIDFMGTDAAIFR-----S 201

  Fly   231 SAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIA 288
            ..||   ...||.:::||||.:|.||.:..|.:       .|||||:|...:.....|.::|.||
Mouse   202 LTKR---NAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKERLTDNNRSTKQIHSMIA 263

  Fly   289 RVCKKDVGGKNLLAHNWATYLKARLNCSISGEF--PFYFNEIQSVYQLPSDKSR---FFATFTTS 348
            |:|..|.||:..|.:.|.|:|||||.||::.|.  ..:|:|::.|:.|.:|..|   .:..||||
Mouse   264 RICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTS 328

  Fly   349 TNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSN 405
            ::...|||||.:|:::||..|||.|..:...|.. |.....|:|.||||||        :..|.:
Mouse   329 SSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQ-LISYQGRIPYPRPGTCPGGAFTPNMRTTKD 392

  Fly   406 LPDTVLNFIRSHPLMDKAVNHEHNNPVYYK--RDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGR 468
            .||.|:.|||:||||..::...|..|:..:  .|..:||:.||  |::..:..|.|.::||:.|.
Mouse   393 FPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVD--RVNAADGRYHVLFLGTDRGT 455

  Fly   469 IYKIVQYYRNGESLSKL-LDIFEVAPNEA-IQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDN 531
            :.|:|....|..:..:| |:..||..|.. |..|:||..::.||:.::..:.|:.|..|:.....
Mouse   456 VQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTA 520

  Fly   532 CFRC--VRDPYCGWDKEA-----------------------NTCRPYELDLLQDVANETSDICDS 571
            |..|  .|||||.||..:                       ..||.:.|...::.|.
Mouse   521 CADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAE-------- 577

  Fly   572 SVLKKKIVVTYG---QSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLV 633
                   :|.||   .|..|.|..|.|:.    .:.|........|.|::.:  :.|..|.:||:
Mouse   578 -------IVQYGVRNNSTFLECAPKSPQA----SIKWLLQKDKDRRKEVKLN--ERIIATSQGLL 629

  Fly   634 VVSVNEADGGRYDC 647
            :.||.::|.|.|.|
Mouse   630 IRSVQDSDQGLYHC 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	160/500 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	21/78 (27%)
Sema3c	NP_038685.3	Sema_3C	45..514	CDD:200512	161/501 (32%)
		PSI	513..550	CDD:214655	10/36 (28%)
		Ig_Semaphorin_classIII	575..664	CDD:143279	22/90 (24%)
		IG_like	579..653	CDD:214653	21/71 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910