Protein Alignment Sema2a and Sema3c

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_038685.3
• Gene: Sema3c / 20348
• MGIID: 107557
• Length: 751
• Species: Mus musculus
• Alignment Length: 664
• Identity: 199/664 - (29%)
• Similarity: 305/664 - (45%)
• Gaps: 126/664 - (18%)

  Fly    56 DHVREFNCGKLY--------YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEP-- 110
            |.:||....:.:        ||...|:||:|.:|||:.|.:..:|:.|||.          ||
Mouse    34 DELRETKTSEYFSLSHQQLDYRILLMDEDQDRIYVGSKDHILSLNINNISQ----------EPLS 88

  Fly   111 -----TRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRS 170
                 :...|..|...||.....|.|.|||||:.:: ..|||||:.|.:|    :...|....||
Mouse    89 VFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNR-THLYVCGSGAFSP----VCTYLNRGRRS 148

  Fly   171 E---YVIG--VGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNT 230
            |   ::|.  ...|..:|.::|..|:.::.:..       .|:||...:|...|..|||     :
Mouse   149 EDQVFMIDSKCESGKGRCSFNPNVNTVSVMINE-------ELFSGMYIDFMGTDAAIFR-----S 201

  Fly   231 SAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIA 288
            ..||   ...||.:::||||.:|.||.:..|.:       .|||||:|...:.....|.::|.||
Mouse   202 LTKR---NAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKERLTDNNRSTKQIHSMIA 263

  Fly   289 RVCKKDVGGKNLLAHNWATYLKARLNCSISGEF--PFYFNEIQSVYQLPSDKSR---FFATFTTS 348
            |:|..|.||:..|.:.|.|:|||||.||::.|.  ..:|:|::.|:.|.:|..|   .:..||||
Mouse   264 RICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTS 328

  Fly   349 TNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSN 405
            ::...|||||.:|:::||..|||.|..:...|.. |.....|:|.||||||        :..|.:
Mouse   329 SSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQ-LISYQGRIPYPRPGTCPGGAFTPNMRTTKD 392

  Fly   406 LPDTVLNFIRSHPLMDKAVNHEHNNPVYYK--RDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGR 468
            .||.|:.|||:||||..::...|..|:..:  .|..:||:.||  |::..:..|.|.::||:.|.
Mouse   393 FPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVD--RVNAADGRYHVLFLGTDRGT 455

  Fly   469 IYKIVQYYRNGESLSKL-LDIFEVAPNEA-IQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDN 531
            :.|:|....|..:..:| |:..||..|.. |..|:||..::.||:.::..:.|:.|..|:.....
Mouse   456 VQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTA 520

  Fly   532 CFRC--VRDPYCGWDKEA-----------------------NTCRPYELDLLQDVANETSDICDS 571
            |..|  .|||||.||..:                       ..||.:.|...::.|.
Mouse   521 CADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAE-------- 577

  Fly   572 SVLKKKIVVTYG---QSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLV 633
                   :|.||   .|..|.|..|.|:.    .:.|........|.|::.:  :.|..|.:||:
Mouse   578 -------IVQYGVRNNSTFLECAPKSPQA----SIKWLLQKDKDRRKEVKLN--ERIIATSQGLL 629

  Fly   634 VVSVNEADGGRYDC 647
            :.||.::|.|.|.|
Mouse   630 IRSVQDSDQGLYHC 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	160/500 (32%)
		PSI	527..>550	CDD:396154	9/47 (19%)
		Ig_Semaphorin_C	573..668	CDD:409368	21/78 (27%)
		Ig strand A	573..579	CDD:409368	0/5 (0%)
		Ig strand B	583..591	CDD:409368	3/10 (30%)
		Ig strand C	601..607	CDD:409368	1/5 (20%)
		Ig strand C'	609..612	CDD:409368	0/2 (0%)
		Ig strand D	622..626	CDD:409368	0/3 (0%)
		Ig strand E	630..637	CDD:409368	2/6 (33%)
		Ig strand F	643..652	CDD:409368	3/5 (60%)
		Ig strand G	655..668	CDD:409368
Sema3c	NP_038685.3	Sema_3C	45..514	CDD:200512	161/501 (32%)
		PSI	513..550	CDD:214655	10/36 (28%)
		Ig_Sema3	574..664	CDD:409455	22/91 (24%)
		Ig strand A	574..580	CDD:409455	1/20 (5%)
		Ig strand B	585..593	CDD:409455	2/7 (29%)
		Ig strand C	599..605	CDD:409455	1/9 (11%)
		Ig strand C'	607..610	CDD:409455	0/2 (0%)
		Ig strand D	619..623	CDD:409455	1/3 (33%)
		Ig strand E	626..633	CDD:409455	2/6 (33%)
		Ig strand F	639..648	CDD:409455	3/5 (60%)
		Ig strand G	651..664	CDD:409455