DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2a and Sema3a

DIOPT Version :9

Sequence 1:NP_477507.1 Gene:Sema2a / 36846 FlyBaseID:FBgn0011260 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_001230001.1 Gene:Sema3a / 20346 MGIID:107558 Length:772 Species:Mus musculus


Alignment Length:654 Identity:215/654 - (32%)
Similarity:324/654 - (49%) Gaps:104/654 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 ADHVREFN--CGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVS 117
            :::|..||  .....|.||.::|:|..|||||.|.:|..||.||  .:..:.|..:..||.|  .
Mouse    42 SNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNI--KDFQKIVWPVSYTRRD--E 102

  Fly   118 CVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNA-----------HNPKDYVIYANLTHLPRSE 171
            |...||..:.:|.|.::|:::.:| ..||.|||.|           |:|:|     |:..|..|.
Mouse   103 CKWAGKDILKECANFIKVLEAYNQ-THLYACGTGAFHPICTYIEVGHHPED-----NIFKLQDSH 161

  Fly   172 YVIGVGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLE 236
            :..|.|    |.||||...:.::.::.       .|||||.|:|...|..||||..::...    
Mouse   162 FENGRG----KSPYDPKLLTASLLIDG-------ELYSGTAADFMGRDFAIFRTLGHHHPI---- 211

  Fly   237 YKFKRTLKYDSKWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVCKKD 294
                ||.::||:||:.|.|:.:..|.|       .|||||||.|::..:.|||.::||.::||.|
Mouse   212 ----RTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKND 272

  Fly   295 VGGKNLLAHNWATYLKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIG 354
            .||...|.:.|.|:|||||.||:.|.  ...:|:|:|.|:.:.|...:   .:..||||:|...|
Mouse   273 FGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKG 337

  Fly   355 SAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC-------VNDTSNLPDTVLN 412
            ||||.:.:::::..|.|.:..:...|..|:| ...|||.||||||       .:.|.:|||.|:.
Mouse   338 SAVCMYSMSDVRRVFLGPYAHRDGPNYQWVP-YQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVIT 401

  Fly   413 FIRSHPLMDKAVNHEHNNPVYYKRDL--VFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQ- 474
            |.||||.|...|...:|.|:..|.|:  .||::|||  |:|..:.:|.|.::||::|.:.|:|. 
Mouse   402 FARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVD--RVDAEDGQYDVMFIGTDVGTVLKVVSV 464

  Fly   475 ----YYRNGESLSKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC 535
                ::...|.|.:.:.:|. .|. .|..||:|..::.||||:...:.|:.|..|:.....|..|
Mouse   465 PKETWHDLEEVLLEEMTVFR-EPT-TISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAEC 527

  Fly   536 --VRDPYCGWDKEANTCRPY-----ELDLLQDVAN----------ETSDICDSSVLKKKIVVTYG 583
              .|||||.||  .::|..|     .....||:.|          :..|......|:::|:  ||
Mouse   528 CLARDPYCAWD--GSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERII--YG 588

  Fly   584 ---QSVHLGCFVKIPEVLKNEQVTWYHHSKDKGR-YEIRYSPTKYIETTERGLVVVSVNEADGGR 644
               .|..|.|..|....|    |.|....:::.| .|||..  .:|..||:||::.|:.:.|.|.
Mouse   589 VENSSTFLECSPKSQRAL----VYWQFQRRNEDRKEEIRMG--DHIIRTEQGLLLRSLQKKDSGN 647

  Fly   645 YDCH 648
            |.||
Mouse   648 YLCH 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2aNP_477507.1 Sema_2A 66..523 CDD:200499 169/493 (34%)
Ig_Semaphorin_C 573..664 CDD:143180 26/80 (33%)
Sema3aNP_001230001.1 Sema_3A 26..518 CDD:200510 173/509 (34%)
PSI 516..>552 CDD:214655 12/37 (32%)
Ig_Sema3 580..671 CDD:409455 26/80 (33%)
Ig strand B 594..598 CDD:409455 1/3 (33%)
Ig strand C 606..610 CDD:409455 2/7 (29%)
Ig strand E 633..637 CDD:409455 2/3 (67%)
Ig strand F 647..652 CDD:409455 3/5 (60%)
Ig strand G 664..667 CDD:409455
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 729..772
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11477
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31358
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.910

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