DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and SEMA3C

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001337049.1	Gene:	SEMA3C / 10512	HGNCID:	10725	Length:	769	Species:	Homo sapiens

Alignment Length:	664	Identity:	198/664 - (29%)
Similarity:	305/664 - (45%)	Gaps:	126/664 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DHVREFNCGKLY--------YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCN----RDVINL 108
            |.:||....:.:        ||...|:||:|.:|||:.|.:..:|:.|||....:    ...|.:
Human    52 DELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKV 116

  Fly   109 EPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSE-- 171
            |       .|...||.....|.|.|||||:.:: ..|||||:.|.:|    :...|....|||
Human   117 E-------ECKMAGKDPTHGCGNFVRVIQTFNR-THLYVCGSGAFSP----VCTYLNRGRRSEDQ 169

  Fly   172 -YVIG--VGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAK 233
             ::|.  ...|..:|.::|..|:.::.:..       .|:||...:|...|..|||     :..|
Human   170 VFMIDSKCESGKGRCSFNPNVNTVSVMINE-------ELFSGMYIDFMGTDAAIFR-----SLTK 222

  Fly   234 RLEYKFKRTLKYDSKWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVC 291
            |   ...||.:::||||.:|.||.:..|.:       .|||||:|...:.....|.::|.|||:|
Human   223 R---NAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARIC 284

  Fly   292 KKDVGGKNLLAHNWATYLKARLNCSISGEF--PFYFNEIQSVYQLPSDKSR---FFATFTTSTNG 351
            ..|.||...|.:.|.|:|||||.||::.|.  ..:|:|::.|:.|.:|..|   .:..||||::.
Human   285 PNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSV 349

  Fly   352 LIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC--------VNDTSNLPD 408
            ..|||||.:|:::||..|||.|..:...|.. |.....|:|.||||||        :..|...||
Human   350 FKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQ-LISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPD 413

  Fly   409 TVLNFIRSHPLMDKAVNHEHNNPVYYK--RDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYK 471
            .|:.|||:||||..::...|..|:..:  .|..:||:.||  |::..:..|.|.::||:.|.:.|
Human   414 DVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVD--RVNAADGRYHVLFLGTDRGTVQK 476

  Fly   472 IVQYYRN----GESLSKLLDIFEVAPNEA-IQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDN 531
            :|....|    ||.:.:.|::|:   |.| |..|:||..::.||:.::..:.|:.|..|:.....
Human   477 VVVLPTNNSVSGELILEELEVFK---NHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTA 538

  Fly   532 CFRC--VRDPYCGWDKEA-----------------------NTCRPYELDLLQDVANETSDICDS 571
            |..|  .|||||.||..:                       ..||.:.|...::.|.
Human   539 CADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAE-------- 595

  Fly   572 SVLKKKIVVTYG---QSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLV 633
                   :|.||   .:..|.|..|.|:.    .:.|........|.|::.:  :.|..|.:||:
Human   596 -------IVQYGVKNNTTFLECAPKSPQA----SIKWLLQKDKDRRKEVKLN--ERIIATSQGLL 647

  Fly   634 VVSVNEADGGRYDC 647
            :.||..:|.|.|.|
Human   648 IRSVQGSDQGLYHC 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	160/500 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	20/78 (26%)
SEMA3C	NP_001337049.1	Sema_3C	63..532	CDD:200512	161/501 (32%)
		PSI	531..568	CDD:214655	10/36 (28%)
		Ig_Semaphorin_classIII	593..682	CDD:143279	21/90 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910