DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and SEMA4D

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001358123.1	Gene:	SEMA4D / 10507	HGNCID:	10732	Length:	862	Species:	Homo sapiens

Alignment Length:	654	Identity:	205/654 - (31%)
Similarity:	317/654 - (48%)	Gaps:	120/654 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KHGADHVREFNCGKLY-YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDV 115
            :|...|:.:|:...:| |....::||:||||:||.:.||.||..|||.   .:..:..:.:.|..
Human    33 EHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISE---KQHEVYWKVSEDKK 94

  Fly   116 VSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLG 179
            ..|..||||:..:|.|::||:|.: ....||||||||..|. |::...:...|.::|.      |
Human    95 AKCAEKGKSKQTECLNYIRVLQPL-SATSLYVCGTNAFQPACDHLNLTSFKFLGKNED------G 152

  Fly   180 IAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLK 244
            ..:||:||..:.|::.|:.       .|||||:..|..::.:|.|...:  |..|.||..
Human   153 KGRCPFDPAHSYTSVMVDG-------ELYSGTSYNFLGSEPIISRNSSH--SPLRTEYAI----- 203

  Fly   245 YDSKWLDKPNFVGSFDI---------GE--YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGK 298
               .||::|:||.: |:         ||  .|||||.|.:|||....:.:..|||||||.|.||.
Human   204 ---PWLNEPSFVFA-DVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL 264

  Fly   299 NLLAHNWATYLKARLNCS--ISGEFPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVC 358
            ..|...|.::|||||.||  .||   ..||.::.|:.|.|...:   |:|.||...|.:..||||
Human   265 RTLQKKWTSFLKARLICSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVC 326

  Fly   359 SFHINEIQAAF-NGKFKEQSS---SNSAWLPVLNSRVPEPRPGTCV-------NDTS--NLPDTV 410
            :::::..:..| :||:.:.::   |::.|:. .|..||:||||.|:       |.||  ||||..
Human   327 AYNLSTAEEVFSHGKYMQSTTVEQSHTKWVR-YNGPVPKPRPGACIDSEARAANYTSSLNLPDKT 390

  Fly   411 LNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQ 474
            |.|::.|||||.:|....|.|...|:|:.:|::|||:.: :|  ...|.|.:|.|:.|.::|.:
Human   391 LQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALD--GTVYDVMFVSTDRGALHKAI- 452

  Fly   475 YYRNGESLSKLLDIFE----VAPNEAIQVMEISQTR--KSLYIGTDHRIKQIDLAMCNRRYDNCF 533
                  ||...:.|.|    ....|.:|.:.:|..:  :.:|.|::..:.|..||.|. ::..|.
Human   453 ------SLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCG-KHGTCE 510

  Fly   534 RCV--RDPYCGWDKEANTC------RPYELDLLQDVANETSDIC--DSSVLKKKIVVTYGQSVHL 588
            .||  |||||.|.....||      ......|:|:::.:.| :|  .|....::....:|.:..|
Human   511 DCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDAS-VCPDKSKGSYRQHFFKHGGTAEL 574

  Fly   589 GC---------FVKIPE-VLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGG 643
            .|         |.|... |||.|                  || ||.....:.|::.:::|.|.|
Human   575 KCSQKSNLARVFWKFQNGVLKAE------------------SP-KYGLMGRKNLLIFNLSEGDSG 620

  Fly   644 RYDC 647
            .|.|
Human   621 VYQC 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	164/494 (33%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	19/85 (22%)
SEMA4D	NP_001358123.1	Sema_4D	31..501	CDD:200520	167/508 (33%)
		PSI	503..554	CDD:214655	15/52 (29%)
		Ig_Sema4D_like	559..645	CDD:143281	19/85 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870