Protein Alignment Sema2a and SEMA4D

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_006369.3
• Gene: SEMA4D / 10507
• HGNCID: 10732
• Length: 862
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 205/654 - (31%)
• Similarity: 317/654 - (48%)
• Gaps: 120/654 - (18%)

  Fly    52 KHGADHVREFNCGKLY-YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDV 115
            :|...|:.:|:...:| |....::||:||||:||.:.||.||..|||.   .:..:..:.:.|..
Human    33 EHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISE---KQHEVYWKVSEDKK 94

  Fly   116 VSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLG 179
            ..|..||||:..:|.|::||:|.: ....||||||||..|. |::...:...|.::|.      |
Human    95 AKCAEKGKSKQTECLNYIRVLQPL-SATSLYVCGTNAFQPACDHLNLTSFKFLGKNED------G 152

  Fly   180 IAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLK 244
            ..:||:||..:.|::.|:.       .|||||:..|..::.:|.|...:  |..|.||..
Human   153 KGRCPFDPAHSYTSVMVDG-------ELYSGTSYNFLGSEPIISRNSSH--SPLRTEYAI----- 203

  Fly   245 YDSKWLDKPNFVGSFDI---------GE--YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGK 298
               .||::|:||.: |:         ||  .|||||.|.:|||....:.:..|||||||.|.||.
Human   204 ---PWLNEPSFVFA-DVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL 264

  Fly   299 NLLAHNWATYLKARLNCS--ISGEFPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVC 358
            ..|...|.::|||||.||  .||   ..||.::.|:.|.|...:   |:|.||...|.:..||||
Human   265 RTLQKKWTSFLKARLICSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVC 326

  Fly   359 SFHINEIQAAF-NGKFKEQSS---SNSAWLPVLNSRVPEPRPGTCV-------NDTS--NLPDTV 410
            :::::..:..| :||:.:.::   |::.|:. .|..||:||||.|:       |.||  ||||..
Human   327 AYNLSTAEEVFSHGKYMQSTTVEQSHTKWVR-YNGPVPKPRPGACIDSEARAANYTSSLNLPDKT 390

  Fly   411 LNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQ 474
            |.|::.|||||.:|....|.|...|:|:.:|::|||:.: :|  ...|.|.:|.|:.|.::|.:
Human   391 LQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALD--GTVYDVMFVSTDRGALHKAI- 452

  Fly   475 YYRNGESLSKLLDIFE----VAPNEAIQVMEISQTR--KSLYIGTDHRIKQIDLAMCNRRYDNCF 533
                  ||...:.|.|    ....|.:|.:.:|..:  :.:|.|::..:.|..||.|. ::..|.
Human   453 ------SLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCG-KHGTCE 510

  Fly   534 RCV--RDPYCGWDKEANTC------RPYELDLLQDVANETSDIC--DSSVLKKKIVVTYGQSVHL 588
            .||  |||||.|.....||      ......|:|:::.:.| :|  .|....::....:|.:..|
Human   511 DCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDAS-VCPDKSKGSYRQHFFKHGGTAEL 574

  Fly   589 GC---------FVKIPE-VLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGG 643
            .|         |.|... |||.|                  || ||.....:.|::.:::|.|.|
Human   575 KCSQKSNLARVFWKFQNGVLKAE------------------SP-KYGLMGRKNLLIFNLSEGDSG 620

  Fly   644 RYDC 647
            .|.|
Human   621 VYQC 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	164/494 (33%)
		PSI	527..>550	CDD:396154	9/24 (38%)
		Ig_Semaphorin_C	573..668	CDD:409368	19/85 (22%)
		Ig strand A	573..579	CDD:409368	0/5 (0%)
		Ig strand B	583..591	CDD:409368	3/16 (19%)
		Ig strand C	601..607	CDD:409368	1/5 (20%)
		Ig strand C'	609..612	CDD:409368	0/2 (0%)
		Ig strand D	622..626	CDD:409368	2/3 (67%)
		Ig strand E	630..637	CDD:409368	1/6 (17%)
		Ig strand F	643..652	CDD:409368	3/5 (60%)
		Ig strand G	655..668	CDD:409368
SEMA4D	NP_006369.3	Sema_4D	31..501	CDD:200520	167/508 (33%)
		PSI	503..554	CDD:396154	15/52 (29%)
		Ig_Sema4D_like	559..645	CDD:409457	19/85 (22%)
		Ig strand A	559..565	CDD:409457	0/5 (0%)
		Ig strand B	569..577	CDD:409457	2/7 (29%)
		Ig strand C	583..589	CDD:409457	1/5 (20%)
		Ig strand C'	591..594	CDD:409457	0/2 (0%)
		Ig strand D	600..604	CDD:409457	2/3 (67%)
		Ig strand E	607..614	CDD:409457	1/6 (17%)
		Ig strand F	620..629	CDD:409457	3/5 (60%)
		Ig strand G	633..645	CDD:409457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..837