Protein Alignment Sema2a and SEMA6C

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001171532.1
• Gene: SEMA6C / 10500
• HGNCID: 10740
• Length: 962
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 193/585 - (32%)
• Similarity: 295/585 - (50%)
• Gaps: 103/585 - (17%)

  Fly     8 PLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNN--NYGKHGADHVREFNCGKLYYRT 70
            |||.|||||  |:..|.|.:...     ..|....:.||.:  ::.:...|.......|..:.|.
Human     9 PLLLLLLLL--SLPHTQAAFPQD-----PLPLLISDLQGTSPLSWFRGLEDDAVAAELGLDFQRF 66

  Fly    71 FHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTR------DDVVSCVSKGKSQIFDC 129
            ..:|.   ||.|.|.|.||..:||      ...:...|.|.:      .||.:|..:|| ...:|
Human    67 LTLNR---TLLVAARDHVFSFDLQ------AEEEGEGLVPNKYLTWRSQDVENCAVRGK-LTDEC 121

  Fly   130 KNHVRVIQSMDQGDRLYVCGTNAHNP--KDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDNST 192
            .|::||:...| ...|..||||:.:|  :.|    .:|.|.:....:.   |.|:||:|...::.
Human   122 YNYIRVLVPWD-SQTLLACGTNSFSPVCRSY----GITSLQQEGEELS---GQARCPFDATQSNV 178

  Fly   193 AIYVENGNPGGLPGLYSGTNAEFTKADTVIFRT-----DLYNTSAKRLEYKFKRTLKYDSKWLDK 252
            ||:.|.       .|||.|.|:|..:|.|::|:     .|             |:.|||||||.:
Human   179 AIFAEG-------SLYSATAADFQASDAVVYRSLGPQPPL-------------RSAKYDSKWLRE 223

  Fly   253 PNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGK-NLLAHNWATYLKARLNCS 316
            |:||.:.:.|::|||||||.:||....|:..:||:|||||:|:||. ..|..:|.::||.|||||
Human   224 PHFVQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCS 288

  Fly   317 ISGEFPFYFNEIQSVYQLPSD---KSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSS 378
            :.|:..|||:.:|::.. |.:   :|..|..|||.||.:.|||||:|:::||:..|.||||||.|
Human   289 VPGDSTFYFDVLQALTG-PVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRS 352

  Fly   379 SNSAWLPVLNSRVPEPRPGTCV--------NDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYK 435
            .:.||.||...|||.||||:|.        :.:.:|||.||.||::|||:|.||     .||.::
Human   353 LDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAV-----PPVTHQ 412

  Fly   436 RDLVFT-KLVVDKIRIDIL---NQEYIVYYVGTNLGRIYKIVQYYRNGES------LSKLLDIFE 490
            ..|..| :.::.::.:|.:   :....|.::|:|.|.:.|::.  ..|.|      |.:.:|.:.
Human   413 PLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLT--PGGRSGGPEPILLEEIDAYS 475

  Fly   491 VAPNEAIQVMEISQTRKSLYIGTD-HR--------IKQIDLAMCNRRYDNCFR-CV--RDPYCGW 543
            .|.....:..:.::....|.:.|: ||        |..:.|:.| .|:..|.| |:  :||||||
Human   476 PARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRC-ARHGACQRSCLASQDPYCGW 539

  Fly   544  543
            Human   540  539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	165/500 (33%)
		Ig_Semaphorin_C	573..664	CDD:143180
SEMA6C	NP_001171532.1	Sema	53..517	CDD:301699	166/509 (33%)
		PSI	518..570	CDD:279745	11/23 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910