DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and SEMA3A

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_006071.1	Gene:	SEMA3A / 10371	HGNCID:	10723	Length:	771	Species:	Homo sapiens

Alignment Length:	707	Identity:	222/707 - (31%)
Similarity:	338/707 - (47%)	Gaps:	127/707 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGK--------HGADHVREFN--C 63
            |..::.|....:....|:|:|                |.||..:        ..:::|..||  .
Human     4 LTRIVCLFWGVLLTARANYQN----------------GKNNVPRLKLSYKEMLESNNVITFNGLA 52

  Fly    64 GKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFD 128
            ....|.||.::|:|..|||||.|.:|..:|.||  .:..:.|..:..||.|  .|...||..:.:
Human    53 NSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNI--KDFQKIVWPVSYTRRD--ECKWAGKDILKE 113

  Fly   129 CKNHVRVIQSMDQGDRLYVCGTNA-----------HNPKDYVIYANLTHLPRSEYVIGVGLGIAK 182
            |.|.::|:::.:| ..||.|||.|           |:|:|     |:..|..|.:..|.|    |
Human   114 CANFIKVLKAYNQ-THLYACGTGAFHPICTYIEIGHHPED-----NIFKLENSHFENGRG----K 168

  Fly   183 CPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDS 247
            .||||...:.::.::.       .|||||.|:|...|..||||..::...        ||.::||
Human   169 SPYDPKLLTASLLIDG-------ELYSGTAADFMGRDFAIFRTLGHHHPI--------RTEQHDS 218

  Fly   248 KWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNW 305
            :||:.|.|:.:..|.|       .|||||||.|::..:.|||.::||.::||.|.||...|.:.|
Human   219 RWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKW 283

  Fly   306 ATYLKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEI 365
            .|:|||||.||:.|.  ...:|:|:|.|:.:.....:   .:..||||:|...|||||.:.::::
Human   284 TTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDV 348

  Fly   366 QAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC-------VNDTSNLPDTVLNFIRSHPLMDKA 423
            :..|.|.:..:...|..|:| ...|||.||||||       .:.|.:|||.|:.|.||||.|...
Human   349 RRVFLGPYAHRDGPNYQWVP-YQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNP 412

  Fly   424 VNHEHNNPVYYKRDL--VFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQ-----YYRNGES 481
            |...:|.|:..|.|:  .||::|||  |:|..:.:|.|.::||::|.:.|:|.     :|...|.
Human   413 VFPMNNRPIVIKTDVNYQFTQIVVD--RVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEV 475

  Fly   482 LSKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWD 544
            |.:.:.:|. .|. ||..||:|..::.||||:...:.|:.|..|:.....|..|  .|||||.||
Human   476 LLEEMTVFR-EPT-AISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWD 538

  Fly   545 KEANTCRPY-----ELDLLQDVAN-----ETSDICDSS----VLKKKIVVTYG---QSVHLGCFV 592
            ..|  |..|     .....||:.|     ..||:...:    ..:::|:  ||   .|..|.|..
Human   539 GSA--CSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERII--YGVENSSTFLECSP 599

  Fly   593 KIPEVLKNEQVTW-YHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDCH 648
            |....|    |.| :....::.:.|||..  .:|..|::||::.|:.:.|.|.|.||
Human   600 KSQRAL----VYWQFQRRNEERKEEIRVD--DHIIRTDQGLLLRSLQQKDSGNYLCH 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	169/493 (34%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	23/80 (29%)
SEMA3A	NP_006071.1	Sema_3A	26..518	CDD:200510	175/525 (33%)
		PSI	516..>552	CDD:214655	13/37 (35%)
		Ig_Sema3	579..670	CDD:409455	23/80 (29%)
		Ig strand B	593..597	CDD:409455	1/3 (33%)
		Ig strand C	605..609	CDD:409455	2/7 (29%)
		Ig strand E	632..636	CDD:409455	2/3 (67%)
		Ig strand F	646..651	CDD:409455	3/5 (60%)
		Ig strand G	663..666	CDD:409455
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11345
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31358
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920