DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and sema3e

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_002935302.1	Gene:	sema3e / 100494277	XenbaseID:	XB-GENE-922952	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	765	Identity:	210/765 - (27%)
Similarity:	346/765 - (45%)	Gaps:	143/765 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VREFNCGKLYYRTF------HMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVV 116
            :|:.|...:::..|      :::|.::.|:||..:.::.::|:.:|.   |...|:...|...|.
Frog    45 LRDLNRTSVFHSPFLDLNIMYLDEYQERLFVGGRNLLYSLSLEQVSE---NYKEIHWPSTDQQVE 106

  Fly   117 SCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANL---THLPRSE---YVIG 175
            .|..||:.: .:|.|.:||:...:: ..|..|||.|.:|....|.|.|   .||.:.|   :..|
Frog   107 DCSRKGRDK-SECANFIRVLHHYNR-THLLACGTGAFDPVCAFIRAGLRSQEHLFQLEPQKFERG 169

  Fly   176 VGLGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFK 240
            .|    :||:||  ||:.|....|..     |:.|...:|...|..||||..:....
Frog   170 RG----RCPFDP--NSSVISTLTGGE-----LFVGLYNDFWGRDATIFRTTGHLPPI-------- 215

  Fly   241 RTLKYDSKWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGK 298
            ||...|.:.|.:|.||||:.|.:       .:|||:.|.|:|.....:|:|||:.|||..|:||:
Frog   216 RTEHDDDRILTEPKFVGSYMIPDNEDKDDNKMYFFYTEKAIEGDKGVQAIYSRVGRVCANDIGGQ 280

  Fly   299 NLLAHNWATYLKARLNCSISGE--FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVC 358
            .::.:.|.|:||.||.||:.|.  ...:|:|::.|:.|.:..::   .||.|:|::|...|.|:|
Frog   281 RMMVNKWTTFLKTRLICSVPGPNGIDTFFDELEDVFLLHTRDNKNPEIFALFSTTSNIFKGYAIC 345

  Fly   359 SFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVN--------DTSNLPDTVLNFIR 415
            .:|:..|:.||||.|..:......| .:...::|.||||.|.:        .|.:.||..|.|.|
Frog   346 VYHMASIREAFNGPFAHKEGPEYHW-SIYEGKIPYPRPGLCASKVNGGHYGTTKDYPDEALRFAR 409

  Fly   416 SHPLMDKAVNHEHNNPVYYKRDLVFT--KLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYY-R 477
            |||||.::|...|..|:..|.|..:.  ::.||  |::..:.:|.|.::||:.|.:.|::..| :
Frog   410 SHPLMYESVKPTHKKPILIKADGKYNLKQIAVD--RVEAEDGQYHVVFIGTDNGIVLKVITIYNQ 472

  Fly   478 NGESLSKL----LDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--V 536
            ..|::.::    |.:|:| |:..|. ||||..|:.||||:...|.||....|......|..|  .
Frog   473 ETETMEEVILEELQVFKV-PDPIIS-MEISAKRQQLYIGSASSIVQIKTHQCEMYGTACADCCLA 535

  Fly   537 RDPYCGWDKEANTC-RPYELDLLQDVANETSDICDSSVLKKKIVVTYGQSVH------------- 587
            |||||.||  ..:| |.|.|...........|:...:.:::    .:||..|
Frog   536 RDPYCAWD--GISCSRYYPLGSHSKRRFRRQDVRHGNAVQQ----CFGQQFHGETLEKTEEHLAY 594

  Fly   588 --------LGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGR 644
                    |.|   :|..|:::.|.:.....|..:.|::  ..:.:..|:.||:...:::.|.|.
Frog   595 GIENNSTLLEC---MPRSLQSKVVWFVQRGHDTRKEEVK--TDERVVKTDFGLLFFKLHKMDAGI 654

  Fly   645 YDC----HLGGSLLCSYNI--------------------------TVDAH--RCTPPNKSNDYQK 677
            |.|    |:...::....:                          .|.||  :.|.|......|.
Frog   655 YFCQTVEHMFVHIIRKITLEIVDEERVDDMFHKEEEEEPVAKMPCPVQAHVPQATRPWYKEFLQL 719

  Fly   678 I-YSDWCHEFEKYKTAMKSW--EKKQAQCSTRQNFSSNQHPNEIFRKPNV 724
            | ||:: |:.|:|  ..|.|  ::::.:....||.....:|.|  |||.|
Frog   720 IGYSNF-HKVEEY--CEKVWCTDRRRKKLKAPQNKWKYGNPQE--RKPKV 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	153/495 (31%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	19/141 (13%)
sema3e	XP_002935302.1	Sema_3E	52..522	CDD:200514	153/498 (31%)
		PSI	521..>550	CDD:214655	11/30 (37%)
		Ig_Semaphorin_classIII	588..678	CDD:143279	15/94 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000