DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and sema5b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_031748739.1	Gene:	sema5b / 100493363	XenbaseID:	XB-GENE-959729	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	709	Identity:	227/709 - (32%)
Similarity:	338/709 - (47%)	Gaps:	130/709 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNIS---SSNCNRDVINLEPTRDDVVSCV 119
            ||:|:       ...::.:|:.|.|||.:.:||::|.|:|   ::..:.|       .|...||.
Frog    73 VRDFS-------QLALDLNRNQLIVGARNYLFRLSLHNVSLIQAAEWSSD-------EDTQRSCQ 123

  Fly   120 SKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCP 184
            ||||:: .:|:|:|||:  :..|.|::.|||||.:|     ......:.....||....|:|:||
Frog   124 SKGKTE-DECQNYVRVL--IVSGKRVFTCGTNAFSP-----VCTSRQVGNLSKVIEKINGVARCP 180

  Fly   185 YDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKW 249
            |||..||||:....|.      ||:.|..:|:..|.||:|:   ..|...|     ||.:|:|||
Frog   181 YDPRHNSTAVMTTRGE------LYAATVIDFSGRDPVIYRS---LGSVPPL-----RTAQYNSKW 231

  Fly   250 LDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLN 314
            |::||||.::|||.:.||||||.|||: :|||.||||:|||||.|.||:.||...|.|::|||||
Frog   232 LNEPNFVAAYDIGIFTYFFFRENAVEH-DCGKTVYSRVARVCKNDYGGRFLLEDTWTTFMKARLN 295

  Fly   315 CSISGEFPFYFNEIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSS 379
            ||..||.|||:||:||.:.|| ::...:..|||:.|.:..||||:|:::.|..||||.|:.|.:.
Frog   296 CSRPGEIPFYYNELQSTFLLP-EQDLIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENP 359

  Fly   380 NSAWLPVLNSRVPEPRPGTCVNDTS---NLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFT 441
            .|||||.:|. :|..:.| .:||.|   ||.:..|...:...||:..|......|:..:..:.|:
Frog   360 RSAWLPTINP-IPNFQCG-ILNDDSPNENLTERSLQDAQRLFLMNDVVQPVSVEPLVTQDSVRFS 422

  Fly   442 KLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAP---NEAIQVMEI 502
            |||||.:: .|.|   |.|.|:||..|.|.|.:. ..|....|..|:...:.|   .|.|:.::|
Frog   423 KLVVDIVQGKDTL---YHVMYIGTEHGTILKALS-TANRSLRSCYLEEMHILPIGQQEPIRSLQI 483

  Fly   503 SQTRKSLYIGTDHRIKQIDLAMCN-RRYDNCFRCVRDPYCGWDKEANTCRPYEL-DLLQDVANET 565
            ..:.:||::|.::.:.::.|..|: .|.:......||||||||.:...|.| .. ..:....|..
Frog   484 LHSNRSLFVGLNNGVLKVPLERCSIYRTEGDRLGARDPYCGWDSKKKRCTPXAYPHYITGPRNTL 548

  Fly   566 SDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPT------KY 624
            |  |..|          |.:||.|            :..|:..:|        :|||      .:
Frog   549 S--CPVS----------GLTVHGG------------RGAWWVRAK--------HSPTGLFGLCPF 581

  Fly   625 IETTERGLVVVSVNEADGGRYD---CHLGG-----------SLLCSYNITVDAHRCTPP------ 669
            ....:..|......:.||.|.:   |...|           |..|.....|....|:.|
Frog   582 PRVCDNPLPRCGGRDCDGTRIEIANCSRNGGWTPWSSWAQCSTSCGIGFQVRQRTCSNPAPRCXG 646

  Fly   670 -----NKSNDYQKIYSD--WCHEFEK-----YKTAMKSWEKKQAQCS----TRQNFSSN 712
                 ....:..|:..|  :|:|...     :.|:..||.|..:.|.    :||....|
Frog   647 RVCVGQSREERVKMMLDGLFCNENSPCPVPIFWTSWGSWTKCSSDCGGGTHSRQRSCEN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	175/466 (38%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	18/110 (16%)
sema5b	XP_031748739.1	Sema_5B	68..504	CDD:200525	178/474 (38%)
		PSI	505..>533	CDD:214655	10/27 (37%)
		TSP1	613..674	CDD:214559	9/60 (15%)
		TSP1	679..725	CDD:214559	8/27 (30%)
		TSP1	810..862	CDD:214559
		TSP1	867..919	CDD:214559
		TSP1	922..963	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940