DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and sema3b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001120908.1	Gene:	sema3b / 100151737	XenbaseID:	XB-GENE-921561	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	778	Identity:	226/778 - (29%)
Similarity:	363/778 - (46%)	Gaps:	136/778 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLQLSPLLALLLLLCSSVS-ETAADYENTWN------FYYERPCCTGNDQGNNNYGKHGADHVR 59
            |||.|..||...|:..:.|: .....|::..:      |..||.||
Frog     6 SLLSLCLLLYFGLIGSNKVTPRLKLSYQDLMSLHGLRTFTLERSCC------------------- 51

  Fly    60 EFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKS 124
                    |....::|:|..|:||..:.:..::|.|||....   .|:.....:....|...||.
Frog    52 --------YDALFLDEERGRLFVGGKNYLMSLSLDNISKQEL---AIHWPAPVEWREECNWAGKD 105

  Fly   125 QIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPR--SEYVIGVGL-----GIAK 182
            ...||.|:|:::|..:: ..|:.|||.|.:|.     ....|:.:  .:.|..:.|     |..:
Frog   106 INVDCMNYVKILQPYNR-THLFTCGTGAFHPT-----CGFVHVGQRTDDTVFKMDLRRMEDGKGR 164

  Fly   183 CPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDS 247
            |||||...:.|:.|.:       .||||...:....|..|||     :..:|...   ||.::||
Frog   165 CPYDPKHIAAAVLVGD-------ELYSGVATDLMGRDFTIFR-----SLGRRPPL---RTEQHDS 214

  Fly   248 KWLDKPNFVGSFDIGE-------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNW 305
            :||::|.||..|.|.|       .:||||:||.||.....|..|:||.::|:.|:||:..|.:.|
Frog   215 RWLNEPKFVKVFWIPESENPDDDKIYFFFKETPVEGAGGVKQSYARIGQICRNDLGGQRSLVNKW 279

  Fly   306 ATYLKARLNCSISGE---FPFYFNEIQSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINE 364
            .|:|||||.||:.|.   ...:|:|::.|:.|.:...|   .:|.|:||::...|||:|.:.:|:
Frog   280 TTFLKARLVCSVPGNEIGGDTHFDELRDVFLLQTRDRRNPLIYALFSTSSSVFRGSAICVYTMND 344

  Fly   365 IQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTC-------VNDTSNLPDTVLNFIRSHPLMDK 422
            ::.||.|.|..:...|..|:. ...:||.||||.|       ...|.:.||.||.|.|:||||..
Frog   345 VRRAFLGPFAHKEGPNYQWVS-YQGKVPYPRPGMCPSKTFGSFESTKSFPDDVLQFARNHPLMFN 408

  Fly   423 AVNHEHNNPVYYKR--DLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIV----QYYRNGES 481
            .|......||:.:.  ||.||:|.||  |:...:.||.|.::||::|.:.|::    |.:.:.|.
Frog   409 PVVPGSGRPVFLRSHGDLSFTQLAVD--RVAAADGEYDVMFIGTDVGSVLKVISVPKQSWHHVEQ 471

  Fly   482 LSKLLDIFEVAPNEA-IQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGW 543
            :  :|:..:|..|.: |..|:||..|:.:|:|:...|.|:.|..|......|..|  .|||||.|
Frog   472 V--VLEELQVFKNASPITTMQISSKRQQIYVGSASGISQLPLHRCGIYGKACAECCLARDPYCAW 534

  Fly   544 DKEA------NTCRPYELDLLQDVAN-ETSDICDS-----SVLKKKIVVTYGQSVHLGCFVKIPE 596
            |..:      ||.|   ....|||.| :.:.:|..     ||.:|:::...|.|:.|.|   :|:
Frog   535 DGASCTRFLPNTKR---RSRRQDVRNGDPNTLCSGEQQRFSVQEKRLLGVEGSSIFLEC---LPK 593

  Fly   597 VLKNEQVTW-YHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDC----HLGGSLLCS 656
            .|: .|||| |..:.:..|.|:::.  :.:..|:||:||.:|...|.|.:.|    |.....|..
Frog   594 SLR-AQVTWTYQKAPESSRTEVQFD--ERVLQTDRGIVVRNVLRRDAGTFICYSSEHGFTQTLLR 655

  Fly   657 YNITVDAHRCTPPNKSNDY---QKI-YSDWCHEFEKYKTAMKSWEKKQAQCSTRQNFSSNQHP 715
            .::.|     .|.:::.::   |:: ::.|..:|.:......|.|:...:..||:..:|  ||
Frog   656 LHLEV-----IPSSRTEEHLGLQRVPHNRWYQDFMRLVQQPGSVEQMCEEIWTRKGRTS--HP 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	154/490 (31%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	27/95 (28%)
sema3b	NP_001120908.1	Sema_3B	43..514	CDD:200511	160/526 (30%)
		PSI	513..550	CDD:214655	13/39 (33%)
		Ig	575..663	CDD:299845	26/98 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020