DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and sema4g

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_002938767.1	Gene:	sema4g / 100038182	XenbaseID:	XB-GENE-856594	Length:	830	Species:	Xenopus tropicalis

Alignment Length:	739	Identity:	209/739 - (28%)
Similarity:	325/739 - (43%)	Gaps:	154/739 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKG 122
            :|.|:.....|.|..:.::|..|||||...:|.:|..|||..  .:..|..|.|......|:.||
Frog    46 LRRFSSRVSNYSTLLLEDERGILYVGARGAIFSLNSTNISQR--YQKAIPWEVTAQKHDECIKKG 108

  Fly   123 KSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNP-------KDYVIYANLTHLPRSEYVIGVGLGI 180
            |:...:|.||:|::...:: ..||||||.|.:|       :.:|:.:....            |.
Frog   109 KNNQTECFNHIRLLLRFNE-THLYVCGTYAFSPLCSFIDSRTFVLSSETEE------------GK 160

  Fly   181 AKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKY 245
            .||||||......:.|:.       |||:.:..||.....:  |.:|...|.|        |.:.
Frog   161 EKCPYDPAKGYVGLLVDG-------GLYTASLYEFRNLPDI--RRNLLQRSLK--------TEES 208

  Fly   246 DSKWLDKPNFVG--------SFDIG--EYVYFFFRETAVEYINC--GKAVYSRIARVCKKDVGGK 298
            :..||:.|.||.        :.::|  :.:|:||.|..||..:.  |....| :|||||.|:|||
Frog   209 NLHWLNDPEFVSAALVQESMNVEVGDDDKIYYFFNEKVVEENSAFLGSKTAS-VARVCKDDMGGK 272

  Fly   299 NLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQLPS---DKSRFFATFTTSTNGLIGSAVCSF 360
            .:|...|.::|||||.|.:    ||| ..::|.|.|..   |.:.|:..|......:..||:|.:
Frog   273 KILQKKWTSFLKARLVCYM----PFY-EVLKSAYTLELGSWDTTIFYGAFILQWKNMEESAICRY 332

  Fly   361 HINEIQAAFNGKFKEQSSSNSAWLPVLNSR----VPEPRPGTCV---------NDTSNLPDTVLN 412
            .|::||..|.|.:.|...|:..|     ||    ||.||||:|:         |.:.:||:.||:
Frog   333 SISDIQKVFEGPYMEYQYSSRKW-----SRYEGEVPSPRPGSCITNEFRMNGFNTSQDLPNNVLD 392

  Fly   413 FIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYI-VYYVGTNLGRIYKIVQYY 476
            |::.||||.:.|......|:..|:::::|::.||  |:..||.||. |.::||:.|.|:|.|
Frog   393 FVKLHPLMYEKVRPVGEQPLLVKKNIIYTRIAVD--RVKALNDEYYDVLFLGTDDGWIHKAV--- 452

  Fly   477 RNGESLSKLLDIFEVAPNEAIQV---------MEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNC 532
                .:..::.|.     |.|||         :.||:.:.:||||....:.||.|..|: :|.:|
Frog   453 ----VIGSMVHII-----EEIQVYKFPQPVENLVISKKQNALYIGAQSGVLQIPLFGCS-QYTSC 507

  Fly   533 FRCV--RDPYCGWDKEANTCRPY-----ELDLLQDVANETS---DICDSSVLKKKI-VVTYGQSV 586
            :.|:  |:|||.||..|  ||..     ...:.||:.|...   :..|...|||:: .|..|..|
Frog   508 YDCILARNPYCAWDGHA--CRDIIGAKNRTQMTQDMQNGNGGCLNSTDDGALKKRVRRVLKGNDV 570

  Fly   587 HLGCFVKIPEVLKN-EQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDCHL- 649
            .|.|     |:..| .:..||.:..||     .|....:......||::........|.|.|:.
Frog   571 LLQC-----ELRSNLARPQWYVNGTDK-----LYDSEGHTRLGVDGLLITDTLPEHSGEYSCYSE 625

  Fly   650 -GG--SLLCSYNITV------DAHRCTP----------PNKSNDYQKIYSD-------WCHEFEK 688
             .|  ||:..|::.|      :.:..||          |..:.:.|.||..       .|.....
Frog   626 ENGLQSLVAVYSLNVLLELPKEKNYSTPTPIIQLPTAAPQSTGNIQFIYISTITILGVLCVVLSI 690

  Fly   689 YKTAMKSWEKKQAQCSTRQNFSSN 712
            ....:...:||:.:.:.|.:.|:|
Frog   691 VLLYVSCQQKKKGKYAVRNSRSTN 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	152/501 (30%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	25/102 (25%)
sema4g	XP_002938767.1	Sema	47..499	CDD:417757	154/508 (30%)
		PSI	500..>527	CDD:214655	12/29 (41%)
		Ig_Sema4B_like	557..643	CDD:409456	25/95 (26%)
		Ig strand B	570..574	CDD:409456	2/3 (67%)
		Ig strand C	582..586	CDD:409456	0/3 (0%)
		Ig strand E	605..609	CDD:409456	2/3 (67%)
		Ig strand F	619..624	CDD:409456	2/4 (50%)
		Ig strand G	636..639	CDD:409456	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010