Protein Alignment S-Lap8 and NPEPL1

DIOPT Version :10

• Sequence 1: NP_611132.1
• Gene: S-Lap8 / 36844
• FlyBaseID: FBgn0034132
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_078939.3
• Gene: NPEPL1 / 79716
• HGNCID: 16244
• Length: 523
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 116/488 - (23%)
• Similarity: 190/488 - (38%)
• Gaps: 74/488 - (15%)

  Fly    98 GRLYQNIDKEYWAVA--------------------VVGLGKEGAGFNAEEVIDEGMENVRVCAAV 142
            |:|...:.:|.|..|                    |..|....:..|:..........||.|...
Human    41 GKLQPRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPCRVSRHNSPSAAHFITRLVRTCLPP 105

  Fly   143 GARALQLQGCTTCHVDGMEYPEQAAEGAAMA------VWRYNVNKRKKNRIAIPKLELYGSTD-- 199
            ||.        .|.|...|.||..|...|:|      ..|...::|.:.:....:..|.|..:
Human   106 GAH--------RCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVTVEFFLVGQDNGP 162

  Fly   200 -QDAWTRGLFKA-ESQNLARRLSDTPANQMTPSIFAQATVDALCPCGVSVEVRSMDWIETQNLNS 262
             :.:..:.|..| :...||.|:.|||.|:|....|.:.........|:...:...:.::|:....
Human   163 VEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGFGG 227

  Fly   263 FLMVAKGSCEPPIILEVSYCGTSPE--ERPILMLGKGLTFNSGGLCLHPKRGMDEYRGAVSGAAV 325
            ...|.|.:..||.:..:|:   :|:  .:.|..:|||:.:::|||.:..|..|...:....|||.
Human   228 IYGVGKAALHPPALAVLSH---TPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAA 289

  Fly   326 CVAAIRAAAALSLPINVSAVLPLCENMPSGMATKPGDVVTLLNGKTMRIKDISLAGTVLLADPLL 390
            .:.|.|||.......|:.||..|.||.....||:|.|:..|.:|||:.|.:....|.::|||.:.
Human   290 VLGAFRAAIKQGFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVS 354

  Fly   391 YAQSTFKPKLVVEVGSM--ASGIRKGLGASATGLWTNNSFLWK-NFQKAGALTGDRLWRMPL--- 449
            ||.......:::::.::  |.||..|...:|.   ..||..|: ...|||...||.:  .||
Human   355 YACKDLGADIILDMATLTGAQGIATGKYHAAV---LTNSAEWEAACVKAGRKCGDLV--HPLVYC 414

  Fly   450 ----WRYFRKLVAPRASYDICSTGEGHASSC----LAAAILYELVPCSDWVHLD----THGTGML 502
                :..|...||...  :..:..:...|||    :|:.|.::..  ..|||||    .|.....
Human   415 PELHFSEFTSAVADMK--NSVADRDNSPSSCAGLFIASHIGFDWP--GVWVHLDIAAPVHAGERA 475

  Fly   503 AKHGVPPYLLKDCMTGRPTRS-IIQFLYQMACK 534
            ...||...|   .:.||.:.. ::..:..:.|:
Human   476 TGFGVALLL---ALFGRASEDPLLNLVSPLGCE 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17_N	53..182	CDD:426984	22/109 (20%)
		Peptidase_M17	215..522	CDD:459978	88/326 (27%)
NPEPL1	NP_078939.3	Peptidase_M17	35..487	CDD:238247	113/468 (24%)