DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S-Lap8 and lap3

DIOPT Version :9

Sequence 1:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001108319.1	Gene:	lap3 / 562854	ZFINID:	ZDB-GENE-060719-1	Length:	517	Species:	Danio rerio

Alignment Length:	534	Identity:	202/534 - (37%)
Similarity:	310/534 - (58%)	Gaps:	27/534 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MISSLRRSTLGLFRCHKALIFARIPAFQQVRCKSEDGSCNTCNLQGVVVGLYAKDGDK-GLKLSP 69
            |:...||:.|...|.|...:|:             |.:..:...:|:|:|:|.:..|. |:.|:.
Zfish     1 MLIPFRRALLTAIRKHNCRLFS-------------DSTVTSSTRKGLVLGVYEQQSDSDGVSLTE 52

  Fly    70 GGEKFDDRVGGKITELIKESGLNGELGVGRLYQNIDKEYWAVAVVGLGKEGAGFNAEEVIDEGME 134
            ....||..:.|:::|::..||...:.|..|::..:.:::.:|.||||||...|...:|..|...|
Zfish    53 AAAAFDRSLSGRLSEMLSLSGPPLKKGKSRIFYGLHQDFPSVVVVGLGKSDPGVCGKENWDNCKE 117

  Fly   135 NVRVCAAVGARALQLQGCTTCHVDGMEYPEQAAEGAAMAVWRYNVNKRKKNRIAIPKLELYGSTD 199
            |:|...:.|.|.||........||.....:.|||||.:.::.|:..|.|| ::.: |...:||.|
Zfish   118 NIRAAVSAGCRQLQDLEVALVEVDPCGDDQSAAEGAVLGLFEYDELKTKK-KVHV-KTRPHGSVD 180

  Fly   200 QDAWTRGLFKAESQNLARRLSDTPANQMTPSIFAQATVD---ALCPCGVSVEVRSMDWIETQNLN 261
            ..||.:|:...:.|||||:|.:.|||.:||::||. |::   :|....|.|..|...|||.:.:.
Zfish   181 AAAWQKGVLYGDGQNLARQLMEAPANHVTPTVFAN-TIEQKLSLFADRVIVHKRPQSWIEGEQMG 244

  Fly   262 SFLMVAKGSCEPPIILEVSYCGTSPE-ERPILMLGKGLTFNSGGLCLHPKRGMDEYRGAVSGAAV 325
            :||.|:|||.|||:.||:.|.|:|.. :.|::::|||:||:|||:.|.|..|||..|..:.|||.
Zfish   245 AFLSVSKGSEEPPVFLELHYKGSSDSAQPPLVLVGKGITFDSGGISLKPSSGMDAMRADMGGAAT 309

  Fly   326 CVAAIRAAAALSLPINVSAVLPLCENMPSGMATKPGDVVTLLNGKTMRIKDISLAGTVLLADPLL 390
            ..:||..||||.:|||:..:.|||||||||.|.||||||...||||::|.:....|.::|||.|.
Zfish   310 VCSAIVTAAALKIPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQIDNTDAEGRLILADALC 374

  Fly   391 YAQSTFKPKLVVEVGSMASGIRKGLGASATGLWTNNSFLWKNFQKAGALTGDRLWRMPLWRYFRK 455
            ||.| |||:.::...::...:...||::|||::||:.:||:...||..:||||:|||||::::.|
Zfish   375 YAHS-FKPRAIINAATLTGAMDVALGSAATGVFTNSDWLWERLHKASVVTGDRVWRMPLFQHYTK 438

  Fly   456 LVAPRASYDICSTGEGHAS--SCLAAAILYELVPCSDWVHLDTHGTGMLAKHGVPPYLLKDCMTG 518
            .|...|..|:.:.|:...|  :|.|||.|.|.|..:.|.|||.  .|::......|||.|. |:|
Zfish   439 QVTDSALADLNNVGKYSRSGGACTAAAFLKEFVSANHWAHLDI--AGVMTNKDEVPYLRKG-MSG 500

  Fly   519 RPTRSIIQFLYQMA 532
            ||||::::|:..:|
Zfish   501 RPTRTLVEFIAGLA 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	192/483 (40%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	187/471 (40%)
lap3	NP_001108319.1	Peptidase_M17	32..510	CDD:238247	192/484 (40%)
lap3	NP_001108319.1	PRK00913	34..511	CDD:234863	192/483 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	O	PTHR11963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1683
SonicParanoid	1	1.000	-	-		X713
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.740