DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S-Lap8 and loopin-1

DIOPT Version :9

Sequence 1:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001097338.1	Gene:	loopin-1 / 36847	FlyBaseID:	FBgn0259795	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	331/507 - (65%)
Similarity:	405/507 - (79%)	Gaps:	11/507 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IPAFQQ--VRCKSEDGSCNTCNLQGVVVGLYAKDGDKGLKLSPGGEKFDDRVGGKITELIKESGL 91
            ||::::  ..|||.         :|||||:|.|||||..|.:......||.:|||:..||:|.|:
  Fly    27 IPSYRRYATSCKSP---------KGVVVGVYTKDGDKPSKTTANAVTLDDALGGKLLTLIRERGM 82

  Fly    92 NGELGVGRLYQNIDKEYWAVAVVGLGKEGAGFNAEEVIDEGMENVRVCAAVGARALQLQGCTTCH 156
            :|..|.|.|:...:.||.||||||:||:||.:|..|.:|||||||||.|..|||||||||....|
  Fly    83 DGTPGKGLLFSGFEGEYQAVAVVGVGKQGAAYNENEELDEGMENVRVAAGTGARALQLQGMYEVH 147

  Fly   157 VDGMEYPEQAAEGAAMAVWRYNVNKRKKNRIAIPKLELYGSTDQDAWTRGLFKAESQNLARRLSD 221
            ||.|:||||||||||:||||||.||||||||..|||::||..|:|||.|||||||||||||||||
  Fly   148 VDSMDYPEQAAEGAALAVWRYNANKRKKNRIQTPKLDMYGKGDRDAWVRGLFKAESQNLARRLSD 212

  Fly   222 TPANQMTPSIFAQATVDALCPCGVSVEVRSMDWIETQNLNSFLMVAKGSCEPPIILEVSYCGTSP 286
            ||||.|||||||||.||||||||||||||||||||..|||||||:||||||||::||.|||||:|
  Fly   213 TPANMMTPSIFAQAAVDALCPCGVSVEVRSMDWIEDMNLNSFLMIAKGSCEPPLLLECSYCGTTP 277

  Fly   287 EERPILMLGKGLTFNSGGLCLHPKRGMDEYRGAVSGAAVCVAAIRAAAALSLPINVSAVLPLCEN 351
            |:||:|:||:||||:||||||.||.|||:||||::||||||..:|||||||||:|::||:||||:
  Fly   278 EDRPVLLLGQGLTFHSGGLCLKPKTGMDQYRGAMAGAAVCVGVLRAAAALSLPLNITAVMPLCEH 342

  Fly   352 MPSGMATKPGDVVTLLNGKTMRIKDISLAGTVLLADPLLYAQSTFKPKLVVEVGSMASGIRKGLG 416
            ||||||.|.|||||||||.||.||::..|..|.|||||||||:|:|||||:::|::|.|:...:|
  Fly   343 MPSGMAVKCGDVVTLLNGTTMGIKNVDKAPVVQLADPLLYAQATYKPKLVIDIGTVAMGVNYAVG 407

  Fly   417 ASATGLWTNNSFLWKNFQKAGALTGDRLWRMPLWRYFRKLVAPRASYDICSTGEGHASSCLAAAI 481
            ..|:||||.:..:|:||:|:|.|||||:||.||::|::::|....:||:|:||.|.|||||||||
  Fly   408 GGASGLWTTSKSVWQNFRKSGGLTGDRVWRFPLFKYYKQIVNKNITYDLCNTGRGPASSCLAAAI 472

  Fly   482 LYELVPCSDWVHLDTHGTGMLAKHGVPPYLLKDCMTGRPTRSIIQFLYQMAC 533
            |:.||||::|.|||..||||.......||||||.|||||||::|||:|||||
  Fly   473 LHTLVPCAEWAHLDIRGTGMTTTINPRPYLLKDSMTGRPTRTVIQFMYQMAC 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	320/476 (67%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	312/465 (67%)
loopin-1	NP_001097338.1	Peptidase_M17	41..518	CDD:238247	319/476 (67%)
loopin-1	NP_001097338.1	PRK00913	43..519	CDD:234863	319/475 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472680
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	1	1.000	-	-		H114266
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19815at7147
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	12	11.800