DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap8 and S-Lap5

DIOPT Version :9

Sequence 1:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_610892.1	Gene:	S-Lap5 / 36515	FlyBaseID:	FBgn0033860	Length:	549	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	358/547 - (65%)
Similarity:	440/547 - (80%)	Gaps:	16/547 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRSQMISSLRRS------------TLGLFRCHKALIFARI-PAFQQVRCKSEDGSCNTCNLQGV 52
            |..::|||:..|:            :..||  ...|...|: ||..|:.....|...|...::||
  Fly     1 MASTRMISAFTRNPRLYQQVTAPWKSYNLF--GTPLFNHRLQPADSQIWRGLADKCDNKTVIKGV 63

  Fly    53 VVGLYAKDGD-KGLKLSPGGEKFDDRVGGKITELIKESGLNGELGVGRLYQNIDKEYWAVAVVGL 116
            |||:|:|:|| |.:|::..|||||||..||::||::|:|:.||||.|:::.|:|.|:.|||||||
  Fly    64 VVGVYSKEGDGKEVKMTSSGEKFDDRTQGKVSELLRETGIKGELGKGKVFMNVDAEFRAVAVVGL 128

  Fly   117 GKEGAGFNAEEVIDEGMENVRVCAAVGARALQLQGCTTCHVDGMEYPEQAAEGAAMAVWRYNVNK 181
            |:||||||..|.|||||||.||.|.||||||||||||...||.||||||||||:|:|:||||.||
  Fly   129 GQEGAGFNDLENIDEGMENARVAAGVGARALQLQGCTEVFVDSMEYPEQAAEGSALAIWRYNSNK 193

  Fly   182 RKKNRIAIPKLELYGSTDQDAWTRGLFKAESQNLARRLSDTPANQMTPSIFAQATVDALCPCGVS 246
            ||::|..:|||:||.|.|.|||||||||||||||||||||:|||||||:||||:.||||||||||
  Fly   194 RKQDRTQVPKLDLYDSPDVDAWTRGLFKAESQNLARRLSDSPANQMTPTIFAQSAVDALCPCGVS 258

  Fly   247 VEVRSMDWIETQNLNSFLMVAKGSCEPPIILEVSYCGTSPEERPILMLGKGLTFNSGGLCLHPKR 311
            ||||||||||..:||||||:||||||||::||||||||:||:||||:||||||:|||||||.||.
  Fly   259 VEVRSMDWIEMNHLNSFLMIAKGSCEPPVVLEVSYCGTAPEDRPILLLGKGLTYNSGGLCLRPKD 323

  Fly   312 GMDEYRGAVSGAAVCVAAIRAAAALSLPINVSAVLPLCENMPSGMATKPGDVVTLLNGKTMRIKD 376
            .:..|||.::||||||||:|||||||||:|::||||||||||||||.||||||||||||||.|.|
  Fly   324 CLHMYRGCMAGAAVCVAAVRAAAALSLPVNITAVLPLCENMPSGMAVKPGDVVTLLNGKTMGIVD 388

  Fly   377 ISLAGTVLLADPLLYAQSTFKPKLVVEVGSMASGIRKGLGASATGLWTNNSFLWKNFQKAGALTG 441
            :|.||||:||||||:||:|:||:|||::.::..|:..|||.||.||:||::|:.|.|:|||.|||
  Fly   389 VSKAGTVVLADPLLFAQTTYKPRLVVDLATVGYGVCAGLGESAAGLFTNSNFIAKQFEKAGGLTG 453

  Fly   442 DRLWRMPLWRYFRKLVAPRASYDICSTGEGHASSCLAAAILYELVPCSDWVHLDTHGTGMLAKHG 506
            |||||:||||||::||.|..::||.:.|.|.||||:|||:|:|||||:||.|:|....|||.:|.
  Fly   454 DRLWRLPLWRYFKQLVTPNLTFDISNRGIGPASSCIAAAVLHELVPCADWAHIDIRNVGMLTRHN 518

  Fly   507 VPPYLLKDCMTGRPTRSIIQFLYQMAC 533
            ..||||||.|||||||:|:||||||||
  Fly   519 PLPYLLKDRMTGRPTRTIVQFLYQMAC 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	337/477 (71%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	331/465 (71%)
S-Lap5	NP_610892.1	Peptidase_M17	60..540	CDD:238247	337/479 (70%)
S-Lap5	NP_610892.1	PepB	83..544	CDD:223338	330/460 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472681
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	1	1.000	-	-		H114266
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19815at7147
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	12	11.800