DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap8 and S-Lap2

DIOPT Version :9

Sequence 1:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_729394.1	Gene:	S-Lap2 / 326209	FlyBaseID:	FBgn0052351	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	213/539 - (39%)
Similarity:	325/539 - (60%)	Gaps:	23/539 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLRRSTLGLFRCHKALIFARIPAFQQVRCKSEDGSCNTCNLQGVVVGLYAKDGDK---GLKLSPG 70
            |:||..:...|.:.:....::...||:...::..|      :|:|||:||.:.||   |: |:|.
  Fly    16 SIRRPEVIRHRRYASQAINQMLQLQQMEICADPPS------RGLVVGVYADEEDKNDAGI-LTPT 73

  Fly    71 GEKFD-DRVGGKITELIKESGLNGELGVGRLYQNIDKE----YWAVAVVGLGKEGAGFNAEEVID 130
            |.|:: .:..|::.|:::.||...:.|..||...::.|    |.||||:|||||..|:|..||:|
  Fly    74 GWKYNVQKTHGRLLEVLRMSGPMPKRGETRLLFAVEPERVPYYSAVAVIGLGKECLGYNPYEVLD 138

  Fly   131 EGMENVRVCAAVGARALQLQGCTTCHVDGMEYPEQAAEGAAMAVWRYNVNKRKKNRIAIPKLELY 195
            |..|.:|...|...|.|.........|:...:.|.||||||:.:|.|...:..|.||::|.::||
  Fly   139 EQKEAIRRSVADACRILAELDTDRIEVENCGHAESAAEGAALGIWIYQELRDPKRRISVPSIDLY 203

  Fly   196 GSTDQ----DAWTRGLFKAESQNLARRLSDTPANQMTPSIFAQATVDALCPCGVSVEVRSMDWIE 256
            .:.|:    :.|..||.||.:|||.|:|.:.|:|.:||:.|||..|:.||..||:|||:...|.|
  Fly   204 ATKDEICDIEGWRIGLQKAAAQNLTRQLQEMPSNLLTPTAFAQNVVEVLCKSGVNVEVKVEGWAE 268

  Fly   257 TQNLNSFLMVAKGSCEPPIILEVSYCGTSPEERPILMLGKGLTFNSGGLCLHPKRGMDEYRGAVS 321
            :|::::||.|.|.||||||.||:||.||..|||||:::|:|:|:::|||||..|:.:...||.::
  Fly   269 SQSMHAFLAVGKASCEPPIFLELSYYGTCAEERPIVLVGQGVTYDAGGLCLKEKQELFHMRGDMT 333

  Fly   322 GAAVCVAAIRAAAALSLPINVSAVLPLCENMPSGMATKPGDVVTLLNGKTMRIKDISLAGTVLLA 386
            ||||.||..||.|.|.||:|:..::|||||:....:.:|||:|..:||||:.::.......::||
  Fly   334 GAAVVVATCRAVAGLRLPVNIRGLIPLCENVIGCNSFRPGDMVKSMNGKTIEVQCTDHEDVLVLA 398

  Fly   387 DPLLYAQSTFKPKLVVEVGSMASGIRKGLGASATGLWTNNSFLWKNFQKAGALTGDRLWRMPLWR 451
            |.|||.|: |.||.::::|:.:..:|:.|..:|.|::||:..||:..:.|...||||:||.|||.
  Fly   399 DALLYGQN-FCPKCIIDIGTCSGYMRQALDEAACGVFTNSEILWQQIKHASMHTGDRVWRFPLWN 462

  Fly   452 YFRKLVAPRASYDICSTGEGHAS-SCLAAAILYELVPCSDWVHLDTHGTGMLAKHGVPPYLLKDC 515
            |:.|.|......|:.:.|.|... .|.|||.|.|.|||..|:|:|  .|.::...|.....|::.
  Fly   463 YYSKAVRAGGRSDVQNYGIGRGGRPCKAAAFLREFVPCGQWMHID--ATNVMITRGDEFEYLREG 525

  Fly   516 MTGRPTRSIIQFLYQMACK 534
            |.|||||::|:|:.|..||
  Fly   526 MAGRPTRTLIEFIAQSICK 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	202/489 (41%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	195/475 (41%)
S-Lap2	NP_729394.1	Peptidase_M17	52..538	CDD:238247	202/489 (41%)
S-Lap2	NP_729394.1	PRK00913	53..539	CDD:234863	202/489 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472706
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1683
SonicParanoid	1	1.000	-	-		X713
	13	12.780