DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap8 and S-Lap4

DIOPT Version :9

Sequence 1:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	298/512 - (58%)
Similarity:	398/512 - (77%)	Gaps:	1/512 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KALIFARIPAFQQVRCKSEDGSCNTCNLQGVVVGLYAKDGDKGLKLSPGGEKFDDRVGGKITELI 86
            |:::..|:|....::.::..|. .:.:.:|:|||:|.|:.|...||:|.|||.:||:.||:.|:|
  Fly     9 KSVVQRRLPVSHLIQIRTACGG-ESKSSKGLVVGVYQKENDNDPKLTPAGEKVNDRLHGKLQEMI 72

  Fly    87 KESGLNGELGVGRLYQNIDKEYWAVAVVGLGKEGAGFNAEEVIDEGMENVRVCAAVGARALQLQG 151
            .:|.:.|.||.|:::.|||.|:.::||||:|.||.|||..|::|||||||||.|.:|||:||..|
  Fly    73 CQSKITGHLGRGKIFNNIDPEFRSMAVVGVGLEGIGFNELEMLDEGMENVRVAAGIGARSLQEIG 137

  Fly   152 CTTCHVDGMEYPEQAAEGAAMAVWRYNVNKRKKNRIAIPKLELYGSTDQDAWTRGLFKAESQNLA 216
            .:...||||:|.|||||||.:|||||.....|:....|||||||.|.|.:.||||:||||:||||
  Fly   138 VSEVFVDGMDYAEQAAEGAVLAVWRYCDMNSKRKPPHIPKLELYESPDYEGWTRGVFKAEAQNLA 202

  Fly   217 RRLSDTPANQMTPSIFAQATVDALCPCGVSVEVRSMDWIETQNLNSFLMVAKGSCEPPIILEVSY 281
            ||:.||||..|||::|||||||||||||::||:|:|:|||.|.|:||||:||||||||:::|::|
  Fly   203 RRMCDTPACCMTPTLFAQATVDALCPCGITVEIRTMEWIEQQRLHSFLMIAKGSCEPPVLMEITY 267

  Fly   282 CGTSPEERPILMLGKGLTFNSGGLCLHPKRGMDEYRGAVSGAAVCVAAIRAAAALSLPINVSAVL 346
            |||:||::|||.||||:|||||.:.|...|||:|||..:||||.|||.:|..|||:|||||..::
  Fly   268 CGTNPEDKPILFLGKGITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRCVAALALPINVCCII 332

  Fly   347 PLCENMPSGMATKPGDVVTLLNGKTMRIKDISLAGTVLLADPLLYAQSTFKPKLVVEVGSMASGI 411
            |||||||||||.||||||||:|.|:|.::::..||.|::||||||.|||:||:|||:|.::.||:
  Fly   333 PLCENMPSGMACKPGDVVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKPRLVVDVATLGSGV 397

  Fly   412 RKGLGASATGLWTNNSFLWKNFQKAGALTGDRLWRMPLWRYFRKLVAPRASYDICSTGEGHASSC 476
            :|..|..|||:::|:.::||.||.||||||||:||:|||.|:||.:.....||:.:.|.|.|:||
  Fly   398 KKAFGGGATGIFSNSHYIWKQFQSAGALTGDRVWRLPLWNYYRKQITDEMGYDLSNDGRGLANSC 462

  Fly   477 LAAAILYELVPCSDWVHLDTHGTGMLAKHGVPPYLLKDCMTGRPTRSIIQFLYQMAC 533
            ||||:|:|||||.||.||||.|||:|.|:|:.|||....|||||||::.||||||||
  Fly   463 LAAAVLHELVPCVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFLYQMAC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	287/476 (60%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	284/465 (61%)
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	287/482 (60%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	287/478 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472690
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	1	1.000	-	-		H114266
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	1	0.950	-	0	Normalized mean entropy	S5230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19815at7147
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	13	12.750