DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap8 and Lap3

DIOPT Version :9

Sequence 1:	NP_611132.1	Gene:	S-Lap8 / 36844	FlyBaseID:	FBgn0034132	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001011910.1	Gene:	Lap3 / 289668	RGDID:	1307985	Length:	519	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	201/499 - (40%)
Similarity:	303/499 - (60%)	Gaps:	14/499 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DGSCNTCNL-QGVVVGLYAKDGDKGL-KLSPGGEKFDDRVGGKITELIKESGLNGELGVGRLYQN 103
            |...:|.:: :|:|:|:|:||.|..: :.:..||.|:..|.|::.|::..||...:.|..|.:..
  Rat    24 DRGLSTADMTKGLVLGIYSKDKDDDVPQFTSAGENFNKLVSGRLREMLNISGPPLKAGKTRTFYG 88

  Fly   104 IDKEYWAVAVVGLGKEGAGFNAEEVIDEGMENVRVCAAVGARALQLQGCTTCHVDGMEYPEQAAE 168
            :.:::.:|.||||||..||.:.:|...||.||:|...|.|.|.:|.....:..||.....:.|||
  Rat    89 LHQDFPSVVVVGLGKRSAGVDDQENWHEGKENIRAAVAAGCRQVQDLELPSVEVDPCGDAQAAAE 153

  Fly   169 GAAMAVWRYNVNKRKKNRIAIPKLELYGSTDQDAWTRGLFKAESQNLARRLSDTPANQMTPSIFA 233
            ||.:.::.|:..|:|| ::|: ..:|:||.|.:||.:|:..|..|||||:|.::|||:|||:.||
  Rat   154 GAVLGLYEYDDLKQKK-KVAV-SAKLHGSGDLEAWEKGVLFASGQNLARQLMESPANEMTPTRFA 216

  Fly   234 QATVDAL--CPCGVSVEVRSMDWIETQNLNSFLMVAKGSCEPPIILEVSYCGTSPE--ERPILML 294
            :.....|  ......|.:|:..|||.|.:.|||.|||||.|||:.||:.|.| ||.  |.|::.:
  Rat   217 EVIEKNLKSASSKTEVHIRTKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYTG-SPNATEAPLVFV 280

  Fly   295 GKGLTFNSGGLCLHPKRGMDEYRGAVSGAAVCVAAIRAAAALSLPINVSAVLPLCENMPSGMATK 359
            |||:||:|||:.:.....||..|..:.|||...:||.:||.|:||||:..:.|||||||||.|.|
  Rat   281 GKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANK 345

  Fly   360 PGDVVTLLNGKTMRIKDISLAGTVLLADPLLYAQSTFKPKLVVEVGSMASGIRKGLGASATGLWT 424
            |||||...||||:::.:....|.::|||.|.||. ||.||:::...::...:...||:.|||::|
  Rat   346 PGDVVRARNGKTIQVDNTDAEGRLILADALCYAH-TFNPKVIINAATLTGAMDVALGSGATGVFT 409

  Fly   425 NNSFLWKNFQKAGALTGDRLWRMPLWRYFRKLVAPRASYDICSTGE-GHASSCLAAAILYELVPC 488
            |:|:||....:|...||||:|||||:.::.:.|......|:.:.|: ..|.:|.|||.|.|.|..
  Rat   410 NSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADVNNLGKYRSAGACTAAAFLREFVTH 474

  Fly   489 SDWVHLDTHGTGMLAKHGVPPYLLKDCMTGRPTRSIIQFLYQMA 532
            :.|.|||.  .|::......|||.|. |:|||||::|:||.:.:
  Rat   475 TKWAHLDI--AGVMTNKDEIPYLRKG-MSGRPTRTLIEFLLRFS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap8	NP_611132.1	Peptidase_M17	51..528	CDD:238247	197/482 (41%)
S-Lap8	NP_611132.1	PepB	66..532	CDD:223338	192/470 (41%)
Lap3	NP_001011910.1	Peptidase_M17	33..511	CDD:238247	197/484 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	O	PTHR11963
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X713
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710