Protein Alignment ITGAM and YJL132W

DIOPT Version :10

• Sequence 1: NP_001139280.1
• Gene: ITGAM / 3684
• HGNCID: 6149
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_012403.1
• Gene: YJL132W / 853309
• SGDID: S000003668
• Length: 750
• Species: Saccharomyces cerevisiae
• Alignment Length: 823
• Identity: 151/823 - (18%)
• Similarity: 266/823 - (32%)
• Gaps: 265/823 - (32%)

Human    93 LAATTS-PPQLLACGPTVH---------QTCSENTY--VKGLCFLFGSNLRQQPQKFPEALRGCP 145
            :..||| ..:|.|.|.|.|         .:..||.|  :|...|            ||:||..|.
Yeast    13 ICLTTSIVTKLQAAGVTTHLFYLTRGAPLSLKENYYPWLKAGSF------------FPDALYSCA 65

Human   146 QED---SDIA-------FLI---------DGSGSII--PHDFRRMKEFVSTVMEQLKKSKTLFSL 189
            ..:   ||.|       ||:         .|....:  .|....:|.|:..|........:..||
Yeast    66 PSNKDWSDFAEFTHWPNFLMIAVSYWQQKYGQNDRLRGTHGSLALKSFLIGVFTHQIVDVSWHSL 130

Human   190 MQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGAR-------- 246
            :   .::|:|...:           |...|:..|...||.....|:.|...:.|..|
Yeast   131 V---TDYRMHGLLR-----------VLSETEFDGDIETAHTFLDVMGEFLTLNNVIRDSNNNENW 181

Human   247 ----KNAFK------ILVVITDGEKFGDPLGYEDVIPEADREGVIR----YVIGVGDAFRSEKSR 297
                ::.:|      ::.:|.:.....:.|.|      |:.|..::    ..|..|..|||:::
Yeast   182 DFLTRSDWKLPREEDLMEIIRNAGLSKEKLSY------AELEFCVKRGMAAAISEGYLFRSQRN- 239

Human   298 QELNTIASKPPRDHVFQVN-------NFEALKTIQNQLREKIFAIEGTQTGSSSSFE-----HEM 350
            |.|..|.|..||.:...:|       |..|:........|.:|..|.|....:....     ..:
Yeast   240 QLLTNIYSTSPRANDLILNHWLGGQSNLVAMLQRCVPFFETLFHDENTNEAQAEELRLCANLPPV 304

Human   351 SQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKS-----TFINMTRVDSDMNDAYLGYAAAI 410
            ||:..:|.     ||:|::.:.  .|...:..|..||     |.:.|.:...|..| ||..:|.
Yeast   305 SQKRINAR-----PLVSSLKAR--KGNSHIVVSPMKSFSDFGTSLTMGKFREDNKD-YLAVSAP- 360

Human   411 ILRNRVQSL------VLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSN 469
             |.:.|.::      :|...|.:...::   :..|.|:       |:::|.|..:.:
Yeast   361 -LEDTVGAIYIVPWDILTVARKEDFSIL---QPITAMY-------GSKVGTYKASDV-------- 406

Human   470 GSTDLVLIGAPHYYEQTRGGQVSVCPLP---RGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDV 531
               |.:|:..|           ..|.:.   :|.:.     ..:..|..:...:...|:|  |:.
Yeast   407 ---DYLLVSQP-----------GTCTIDFYFKGVKI-----LTIKDETTEEAHQLQFAVT--GNF 450

Human   532 NGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISP--SHSQR--------------IAGSKLSPR 580
            ..||:.|:.:.:|....|...:..|  ..||.|..  ::|.:              :.|..:...
Yeast   451 YDDKIPDLVVSSPSYGANETGIATF--IPGSSIISYLTNSDKYQVVDISTFKGVINLDGYPMKIP 513

Human   581 LQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARN-VFECND--- 641
            .|:||.::..........|:.:|..:.|.|.:..|..:..:...:.:    :.:| |....|
Yeast   514 FQHFGATIQISDTTDKQKLIYITCQSLGTVFVYSSNDLHDLSIPIYY----ITKNGVIPAKDSDH 574

Human   642 ---QVVKGKEAGEV-----------------------RVCLHVQKSTRDRLREGQIQSVVTYDLA 680
               .::..||.|..                       .|.::::||       |||:..:...|.
Yeast   575 VEWHIIPSKEHGMFGAAIYSWNFEGMSFVAVSQPMFDTVFIYIEKS-------GQIEFFLKLVLK 632

Human   681 LDSGRPH------SRAVFNETK-----------------------------NSTRRQTQVLGLTQ 710
            :.:....      |..:||:.:                             |..:|:|.   |..
Yeast   633 IKTKSDSIPDEFGSSLLFNDEEKKLYVSSPGSFDARGSIWKISMDELLKAGNDPKRKTL---LIN 694

Human   711 TCETLKLQLPNCIEDPV-----SPIVLRLNFSLVGTPLSAFGN 748
            ....|.|..|:.....|     |.|:...|..:||.|...:||
Yeast   695 NLRHLMLINPDKSSKGVSNFGNSMILGPQNHLIVGIPQYGYGN 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	18..75
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	76..135		13/53 (25%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	43/221 (19%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	339..390		11/60 (18%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	391..442		11/56 (20%)
		Int_alpha	453..>495	CDD:214549	5/41 (12%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..565		12/57 (21%)
		Int_alpha	517..563	CDD:214549	10/45 (22%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	570..630		9/73 (12%)
		Integrin_alpha2	616..979	CDD:462478	32/203 (16%)
		Integrin_alpha	1130..1144	CDD:459778
		GFFKR motif	1132..1136
YJL132W	NP_012403.1	Zn_dep_PLPC	35..234	CDD:425927	41/230 (18%)
		Int_alpha	334..>374	CDD:214549	10/42 (24%)