DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITGAM and ItgaPS5

DIOPT Version :10

Sequence 1:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens
Sequence 2:NP_611808.2 Gene:ItgaPS5 / 37732 FlyBaseID:FBgn0034880 Length:1018 Species:Drosophila melanogaster


Alignment Length:1304 Identity:253/1304 - (19%)
Similarity:431/1304 - (33%) Gaps:464/1304 - (35%)


- Green bases have known domain annotations that are detailed below.


Human     4 RVLLLTALTLCHGFNLDTENAMTF-------------------QENARGFGQSVVQLQGSRVVVG 49
            |:|.|..|.|.:     ..|||.|                   |..:..||.|:| ::.:.:.||
  Fly     3 RLLFLIFLALKY-----QSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLV-IRPTSIFVG 61

Human    50 AP------QEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSL-AATTSPPQLLACGP 107
            ||      :...:.|:.|::|:|..::|||....|...:......||.|: ..|....:||.|.|
  Fly    62 APRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAP 126

Human   108 TVHQTCSEN-TYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKE 171
            ......::| ..::|:|:.....:...|..            ||:..:     |:||        
  Fly   127 RFFVPKNKNYGQMRGICYWVRDTVADTPPL------------SDVRTI-----SLIP-------- 166

Human   172 FVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVR 236
                              .|..|.|.:.........:.|...|:           .|.|:|    
  Fly   167 ------------------SQAEEHFMLELGLSAHVTDDNSGFLI-----------GAPGVR---- 198

Human   237 ELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELN 301
                        ::|..|::..||                                         
  Fly   199 ------------SWKGSVLVHRGE----------------------------------------- 210

Human   302 TIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLL 366
                                                           :::.:|..|        :
  Fly   211 -----------------------------------------------DLAAQGSYA--------V 220

Human   367 STVGSYDWAGGVFLY----------TSKEKSTFINMTRVDSDM---NDAYLGYAAAIILRNRVQS 418
            ..:.|:||....|.|          :|..:::.:.:|...|.:   ..||:......|:|.    
  Fly   221 KMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRK---- 281

Human   419 LVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVL------- 476
                    .|:                  ..|.|:|.|||.|:.:.|::.:|.||:|:       
  Fly   282 --------LHV------------------FHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNAL 320

Human   477 -----IGAPHYYEQTRG-----GQVSVCPLPRGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDV 531
                 :||.:.: ..:|     .::...||..|                   .|||::|:.:||:
  Fly   321 GDSYDVGAIYVF-INKGLFKFEKKIIRLPLSSG-------------------ARFGSSLSKVGDI 365

Human   532 NGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSP---RLQYFGQSLSGGQD 593
            |.|...|:|:|||..  ..|||::|.| |..|:....|||:......|   ....|||.||.|.|
  Fly   366 NHDGYNDLAVGAPFA--GNGAVFIFLG-SEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSD 427

Human   594 LTMDGLVDLTVGAQG--HVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCL 656
            :..:|..||.:||.|  .|.|.|:.||:::.|.:....|.:...           :|...|..|.
  Fly   428 IDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPE-----------QETITVTACY 481

Human   657 HVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETK-NSTRRQTQVLGLTQTCETLKLQLP 720
            .::.:::.|..:   |..:|:.:.:|  ....|..|...: |....|.|. ||:.:|....:.: 
  Fly   482 RLETTSKARQMQ---QQELTFRMTID--ELLQRVSFAPMRTNEVSFQAQA-GLSGSCRNFSVGV- 539

Human   721 NCIEDPVSPIVLRLNFSLV-GTPLS--AFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLS 782
            :......:||.|.|::.|. ..|.|  ||.....|:.....:..|....|...|. .::|..||.
  Fly   540 HYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCA-AHVCVSDLQ 603

Human   783 I-------TFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRS 840
            :       :|.|.||:.|      .|:..:|  |.||.:|..|........|.:.||        
  Fly   604 LSSKDVNSSFIFGSLEVL------SFSYEIT--NSGEPAYVAQFNVTSSARLPFAKV-------- 652

Human   841 QRSWRLACESASSTEVSGALKSTSCSINHPI----------FPENSEVTFNITFDVDSKASLGNK 895
                                 ..:|.:.|.:          .......:..|.|||...:  |..
  Fly   653 ---------------------PGNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLS--GQS 694

Human   896 LLLKANVTS--------ENNMPRT--------------------------------NKTEFQ--- 917
            |.::|.|:|        :|.|..|                                |..||:   
  Fly   695 LTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHG 759

Human   918 ----------LELPVKYAVYMVVTSHGVSTKY----LNFTASENTSRVMQHQYQVSNLGQRSLPI 968
                      :::|:   .|.|..|.|:.:.:    |...|:..:..|....|..:|...:..|:
  Fly   760 PSIIDELTVYVDVPI---AYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPL 821

Human   969 SLVFLVPVRLNQTVIWDR----PQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNC---SIA 1026
            ........|..:.:..|:    |.|..|:.|     |||.||::        :..|::|   :..
  Fly   822 EDSSRRANRKRRELQQDQYAIMPDVNISDIL-----TKENLPAN--------RTLVLDCLRGNWT 873

Human  1027 VCQRIQCDI---PFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGA 1088
            :|.|.|..:   |    ::..:..:...:..:.::.| .::|:|.:..| :|.:...|.:    |
  Fly   874 ICVRSQMRVQLKP----EQPIDLRISFKVDLNDFVNT-FDYLVIFTNVE-MFKEGDSTSI----A 928

Human  1089 FVRSQTETKVEPF-EVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKR----QYKDMMSEGGPP 1148
            ..|:.....:..: |.|.|:..|:.|.:.|.|||..:|..||||.||||    :.|.::.|....
  Fly   929 LKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSE 993

Human  1149 GAEP 1152
            ..||
  Fly   994 TKEP 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 20/81 (25%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 12/60 (20%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 17/174 (10%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 8/60 (13%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 7/53 (13%)
Int_alpha 453..>495 CDD:214549 13/58 (22%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 20/57 (35%)
Int_alpha 517..563 CDD:214549 19/45 (42%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 22/64 (34%)
Integrin_alpha2 616..979 CDD:462478 79/440 (18%)
Integrin_alpha 1130..1144 CDD:459778 7/17 (41%)
GFFKR motif 1132..1136 2/3 (67%)
ItgaPS5NP_611808.2 FG-GAP 294..332 CDD:460357 10/37 (27%)
Int_alpha 351..403 CDD:214549 23/73 (32%)
Int_alpha 417..463 CDD:214549 19/45 (42%)
Integrin_alpha2 453..837 CDD:462478 79/444 (18%)

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