Protein Alignment ITGAM and ItgaPS4

DIOPT Version :10

• Sequence 1: NP_001139280.1
• Gene: ITGAM / 3684
• HGNCID: 6149
• Length: 1153
• Species: Homo sapiens
• Sequence 2: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 207/923 - (22%)
• Similarity: 351/923 - (38%)
• Gaps: 216/923 - (23%)

Human   348 HEMSQEGFSAAITSNGP--LLSTVGSYDWAGGVFL--------YTSKEKSTFINMTRVDSDMND- 401
            :.|.:.|.||.::.:..  |:...|...|.|.|.|        .:|..:...:|..|..::.|.
  Fly   193 YSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPE 257

Human   402 ---------AYLGYAA----------AIILRNRVQSLVLGAPR-YQHIGLVAMFRQNTGMWESNA 446
                     :|.|||.          :.:|      .|..||| ....|...:|    .::|.:.
  Fly   258 PKNFGQEEFSYFGYAVSSGYFDSSNLSTVL------YVATAPRGNNQFGEAYIF----DIYEDSI 312

Human   447 ----NVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHY-----YEQTRGGQVSVCPLPRGQRA 502
                ..:|...|.|||.|:.:.|::.:|.|| |:|.||.|     |:.   |.:.|. :.:|.
  Fly   313 YKYHEFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDD---GAIYVF-INKGS-- 370

Human   503 RWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPS 567
             :..:..:........||||..|:.:||:|.|...|||:|||..  ..|:|:::.| |.:|:...
  Fly   371 -FTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFA--GNGSVFIYLG-SENGLRDP 431

Human   568 HSQRIAGSKLSPRLQY----FGQSLSGGQDLTMDGLVDLTVGAQG--HVLLLRSQPVLRVKAIME 626
            .||.:......|. :|    ||..||.|.|:..:|..|..:||..  .|.|.|:.||:::.||::
  Fly   432 PSQCLDAPSQQPS-KYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIK 495

Human   627 -----FNPREVARNVFEC------NDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLA 680
                 .||.|...|:..|      :|.  |.|...|..:.:.:...|:.:::
  Fly   496 PKLQNVNPEEERVNITVCYRLSSKSDS--KAKALMEQELVIRIDIDTKSKIK------------- 545

Human   681 LDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSA 745
                    .|||:|...|...........:.|...::::..  ....:||.|.:.:.| ...:..
  Fly   546 --------LAVFDEEHGSQMSFKAKAFHEEICSEFQIEMDK--RAKFTPIALEMQYEL-SKKIPN 599

Human   746 FGNLRPVLAEDA-------QRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNV 803
            .|:    ..||.       .:..|....|...|..| :|..||.|: ...:...||:|......:
  Fly   600 SGD----FCEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKIS-CINASSTLVLGTTAVLRL 658

Human   804 TVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSIN 868
            |..:.|:||.:|..:.:......||..:|                  ..:.:|:.|:  ..|.:|
  Fly   659 TYNITNNGEFAYHPKFSVTNSAGLSLAQV------------------PGNCKVNEAV--MVCDLN 703

Human   869 HPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTS---ENNMPRTNKTEFQLELPVKYAVYM-- 928
            |.......: |.::|...|.:...|..|.::|.|.|   |:| |..||....|.|..|..:|:
  Fly   704 HGQRMAKGD-TDSLTISFDVRQLRGRSLEIQAEVLSARDESN-PENNKLTNVLSLREKADIYVSG 766

Human   929 ----------------------VVTSHGVSTKYLNFTA------------SENTSRVMQHQYQV- 958
                                  .:.|||.|| ..|.|.            |.|...::....::
  Fly   767 VQTNDHVVLKESPYTAEVVNYYEIKSHGPST-LENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQ 830

Human   959 SNLGQRSLPISLVFLVPVRLNQTVI-WDRPQVTFS-----ENLSSTCHTKERLPSHSDFLAEL-- 1015
            |....:.:||:.:.......|...| .|:..:.||     ||:.:.....|:.||.|....:|
  Fly   831 SKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPV 895

Human  1016 RKAPVVNC---SIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHN---HLLIVSTAEI- 1073
            ....|:||   ::.:|..::..:. .|:|.:....:...:||...:|.:.:   :.:|.:..::
  Fly   896 NNTLVLNCQDTNVTLCVPVEIRLE-NGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVH 959

Human  1074 LFND---SVFTLLPGQGAFVRSQTETKVEPFEVPNPLPL----IVGSSVGGLLLLALITAALYKL 1131
            ...|   |.||:            |.|:|...:.....:    |:.|.:.|:|:.:..|.||||.
  Fly   960 KIGDPTLSSFTI------------EKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKR 1012

Human  1132 GFFKRQYKDMMSE 1144
            |||||..||.:.:
  Fly  1013 GFFKRAIKDDLKQ 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	18..75
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	76..135
		vWA_integrins_alpha_subunit	149..324	CDD:238746
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	339..390		11/51 (22%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	391..442		14/71 (20%)
		Int_alpha	453..>495	CDD:214549	17/46 (37%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..565		20/57 (35%)
		Int_alpha	517..563	CDD:214549	19/45 (42%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	570..630		21/70 (30%)
		Integrin_alpha2	616..979	CDD:462478	80/420 (19%)
		Integrin_alpha	1130..1144	CDD:459778	8/13 (62%)
		GFFKR motif	1132..1136		3/3 (100%)
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	24/80 (30%)
		Int_alpha	384..434	CDD:214549	20/52 (38%)
		Int_alpha	447..>492	CDD:214549	15/44 (34%)
		Integrin_alpha2	486..808	CDD:462478	75/376 (20%)