DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITGAM and scb

DIOPT Version :10

Sequence 1:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens
Sequence 2:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster


Alignment Length:1341 Identity:259/1341 - (19%)
Similarity:450/1341 - (33%) Gaps:471/1341 - (35%)


- Green bases have known domain annotations that are detailed below.


Human     7 LLTALTLCHGFN--------LDTENAMTF---QENARGFGQSVVQLQGSRVVVGAP--------Q 52
            ||..::....||        :::...:.|   |..:..||.::|..|.| ::||||        |
  Fly    15 LLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS-IIVGAPRAQSTLESQ 78

Human    53 EIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENT 117
            ..:  |:.|::|:|..:.|.|.|                                          
  Fly    79 RTI--NETGAIYRCSLTNGVCSP------------------------------------------ 99

Human   118 YVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSI-IPHDFRRMKEFVSTVMEQLK 181
                                               :::|..|:: .|                  
  Fly   100 -----------------------------------YVLDSRGNVDAP------------------ 111

Human   182 KSKTLFSLMQYSEEFRIHFTF----KEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNIT 242
                      |||     :||    |:|              |.||.:                .
  Fly   112 ----------YSE-----YTFDSERKDF--------------QWLGGS----------------M 131

Human   243 NGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKP 307
            :|..|:..|:||.   ..:|..|...::.:     .||..:|               .||:||.|
  Fly   132 DGGTKDTDKLLVC---APRFYAPSSRDNHL-----HGVCYWV---------------NNTVASTP 173

Human   308 PRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGP--LLSTVG 370
              .||.:::   .|:....|::|:       ..|:.:||.:.|.:.|.||.:..:..  |:...|
  Fly   174 --QHVTRIS---PLRLKSEQVKEE-------DNGNKASFFYIMGELGLSAHVADDNTKFLIGAPG 226

Human   371 SYDWAGGVFLY-----------TSKEKSTFINMTRVDSDMN---------------------DAY 403
            ...|.|.|.||           :.::.|..:..|..|.|.|                     |:|
  Fly   227 INTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSY 291

Human   404 LGYAAA---IILRNRVQSL-VLGAP--------------RYQHIGLVAMFRQNTGMWESNANVKG 450
            .|||.:   ....|..:.| |..||              |.:.|....:||             |
  Fly   292 FGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFR-------------G 343

Human   451 TQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQRARWQCDAVLYGEQG 515
            .|.|.|||.|:.:.|::.:|.||:::....|..|.:.........:.:|   .:..:..:.....
  Fly   344 EQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKG---FFNFERQILRSPV 405

Human   516 QPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPR 580
            :...|||.||:.|||:|.|...|||:|||..  ..|.|:::.| |.:|:....|||:......|.
  Fly   406 ETMARFGTALSRLGDINHDGYNDVAVGAPFA--GNGTVFIYLG-SENGLRDQPSQRLDAPSQQPS 467

Human   581 LQY----FGQSLSGGQDLTMDGLVDLTVGAQG--HVLLLRSQPVLRVKAIMEFNPREVARNVFEC 639
             :|    ||..||.|.|:..:|..|..:||..  .|.|.|:.||::|.|.::...||:...    
  Fly   468 -KYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPE---- 527

Human   640 NDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQ 704
                   :|..::..|..:..::.|:|.:.|..::   .:|:|  :...|..|.:|:.:......
  Fly   528 -------QEKVKITACYRLSTTSTDKLVQEQELAI---RIAMD--KQLKRVKFTQTQTNEISFKV 580

Human   705 VLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLV-GTPLS-AFGNLRPVLAEDAQRLFTALFPF 767
            .....:.|...:.|:....:|..:||.|.:::.|. ..|.| .|.....::.....::.|....|
  Fly   581 NANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIF 645

Human   768 EKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKV 832
            ...|..| :|..||.:....:| ...::|......:...:.|.||.:|..|........|::.:|
  Fly   646 STGCATD-VCTADLQLRSKDVS-PTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV 708

Human   833 STLQNQRSQRSWRLACESASSTEVSGALKSTSCSIN--HPIFPENSEVTFNITFDVDSKASLGNK 895
            ..            .|:...:..|        |.:|  .|:...::: :..|:|||...:  |..
  Fly   709 PG------------NCKVVDAVMV--------CDLNRGRPLAKGDTD-SVTISFDVSQLS--GQS 750

Human   896 LLLKANVTS---ENNMPRTNK-------TEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSR 950
            |::.|.|.|   |.| |..|:       .||.          .:..|.|.:...::.....|::.
  Fly   751 LIIHAEVFSTGYEQN-PTDNRQTNVIGLKEFT----------EIDASGGQTNSQIDLEHYSNSAE 804

Human   951 VMQHQYQVSNLGQRSL-PISLVFLVPV------------------------------------RL 978
            :: :.|::.:.|...: .:::.|.:|:                                    :.
  Fly   805 IV-NNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQN 868

Human   979 NQTVIWDRPQV--TFSENLSSTCHTKER------------------------------------- 1004
            |..::.|..:|  |.|..|..|..|:.|                                     
  Fly   869 NTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKA 933

Human  1005 -------------LPSH----SDFLAEL--RKAPVVNC---SIAVCQRIQCDIPFFGIQEEFNAT 1047
                         :.:|    .||..:|  .:..|.||   .:.:|.|.:       ::..|...
  Fly   934 LTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAE-------MRVHFRPE 991

Human  1048 LKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLL-------PGQGAFVRSQTETKVEP----- 1100
            ...||:..:.:..:..:.::|...|      .|.:|       .|...........::||     
  Fly   992 KSINLNMRYSVDLNEVNAILVDPWE------YFVILTDLKLQKKGDPTSTSFSINRRIEPNIISK 1050

Human  1101 -FEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKD 1140
             .|...|:.:|:.|.:||||||:.|:..|||.|||.|..||
  Fly  1051 HQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKD 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 19/75 (25%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 0/58 (0%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 31/179 (17%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 15/63 (24%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 18/89 (20%)
Int_alpha 453..>495 CDD:214549 11/41 (27%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 21/57 (37%)
Int_alpha 517..563 CDD:214549 20/45 (44%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 21/65 (32%)
Integrin_alpha2 616..979 CDD:462478 69/413 (17%)
Integrin_alpha 1130..1144 CDD:459778 7/11 (64%)
GFFKR motif 1132..1136 3/3 (100%)
scbNP_523750.2 Int_alpha 51..103 CDD:214549 17/131 (13%)
FG-GAP 350..388 CDD:460357 9/37 (24%)
Int_alpha 409..459 CDD:214549 23/52 (44%)
Int_alpha 473..>515 CDD:214549 16/41 (39%)
Integrin_alpha2 509..829 CDD:462478 68/372 (18%)

Return to query results.
Submit another query.