Protein Alignment ITGAM and Itgam

DIOPT Version :10

• Sequence 1: NP_001139280.1
• Gene: ITGAM / 3684
• HGNCID: 6149
• Length: 1153
• Species: Homo sapiens
• Sequence 2: XP_006230276.1
• Gene: Itgam / 25021
• RGDID: 2926
• Length: 1152
• Species: Rattus norvegicus
• Alignment Length: 1153
• Identity: 851/1153 - (73%)
• Similarity: 996/1153 - (86%)
• Gaps: 1/1153 - (0%)

Human     1 MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGAPQEIVAANQRGSLYQ 65
            |.|:.||:|.|||||||||||||.||||||||||||||:||..:||||.||||:.|.||.|:|||
  Rat     1 MTLKFLLVTVLTLCHGFNLDTENPMTFQENARGFGQSVIQLGETRVVVAAPQEVKAVNQTGALYQ 65

Human    66 CDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNL 130
            |||||..|:||.||||.|||||||||||||||.|||||||||||||.|.|||||.|||:||||||
  Rat    66 CDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQLLACGPTVHQNCKENTYVNGLCYLFGSNL 130

Human   131 RQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEE 195
            .::||:||||||||||::|||||||||||||...||::|||||||||:|.:||||||||||||:|
  Rat   131 LRKPQQFPEALRGCPQQESDIAFLIDGSGSINSIDFQKMKEFVSTVMDQFQKSKTLFSLMQYSDE 195

Human   196 FRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGE 260
            ||.||||.:|:.||:|:|.|:||.||.|||.||:||||||||||...||||.||.||||||||||
  Rat   196 FRTHFTFNDFKRNPDPKSHVRPIRQLNGRTKTASGIRKVVRELFQKINGARDNAAKILVVITDGE 260

Human   261 KFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQ 325
            ||||||.||||||||:..|:||||||||:||...:||:||:||||||..||||||:|||||.||:
  Rat   261 KFGDPLNYEDVIPEAEEAGIIRYVIGVGNAFHKPQSRRELDTIASKPAGDHVFQVDNFEALNTIR 325

Human   326 NQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFI 390
            |||:|||||||||||||:|||||||||||||||||||||||.:|||:|||||.|||.||:|:|||
  Rat   326 NQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSAAITSNGPLLGSVGSFDWAGGAFLYPSKDKATFI 390

Human   391 NMTRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGA 455
            |.||:||||||||||||:|:|.||||||||||||||||||||.||:||.|.||.:.::||:|||:
  Rat   391 NTTRIDSDMNDAYLGYASAVISRNRVQSLVLGAPRYQHIGLVVMFKQNFGAWEPHTDIKGSQIGS 455

Human   456 YFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQRARWQCDAVLYGEQGQPWGR 520
            ||||||||||:|::|:|:|:||||||:||:|||||||||||||||||||||:|:|:|:||.||||
  Rat   456 YFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSVCPLPRGQRARWQCEAILHGDQGHPWGR 520

Human   521 FGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFG 585
            ||||||||||||||||||||||||||::|:||||:|||.|.:.||..|||||||::.||.|||||
  Rat   521 FGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTPHSQRIAGARFSPGLQYFG 585

Human   586 QSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAG 650
            ||||||:|||||||:||.|||||.:||:|:|||||::|.|||:|:.:||:||.|.::|||.|:||
  Rat   586 QSLSGGKDLTMDGLMDLAVGAQGRLLLIRAQPVLRLEATMEFSPKNLARSVFACQEEVVKNKDAG 650

Human   651 EVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETL 715
            ||||||||:|:|:||||||.|||.||||||||.||...||.|:||||...|:.:|.||||.||||
  Rat   651 EVRVCLHVRKNTKDRLREGDIQSTVTYDLALDPGRSVVRAFFDETKNGILRRIRVFGLTQKCETL 715

Human   716 KLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDD 780
            ||.||:|:::.||||:||||::|||.||.:..:||||||.:|||:|||:||||||||||.|||||
  Rat   716 KLILPDCVDNSVSPIILRLNYTLVGEPLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDD 780

Human   781 LSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWR 845
            ||||.|.:.::.||||..|:|:|:||:||||||||.|:||.::|..|||||||..|||.|::.||
  Rat   781 LSITVSSIRVNTLVVGDSRDFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSKKPWR 845

Human   846 LACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPR 910
            :..| .||:|..|.||||...|||||||.|||||||:||||||.||||||||||..||||||:.|
  Rat   846 VIAE-PSSSEGQGVLKSTIWDINHPIFPANSEVTFNVTFDVDSDASLGNKLLLKVVVTSENNVSR 909

Human   911 TNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVP 975
            |:|||.|||||||||:||||||...|.|||||||||.||:|:|||||.:||||||.|:|:||.:|
  Rat   910 TDKTESQLELPVKYAIYMVVTSGESSIKYLNFTASEMTSKVIQHQYQFNNLGQRSFPVSVVFWIP 974

Human   976 VRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGI 1040
            |::|:..|||.||||||:||||.|.|:::.||||.|..||.:.||:|||:|||:|||||||.|..
  Rat   975 VQINKVTIWDPPQVTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAVCKRIQCDIPSFNS 1039

Human  1041 QEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPFEVPN 1105
            :|.||.||:|||.|||||:|||:|||:|||||||||||.|.|||||..||::||||||||::|.|
  Rat  1040 KEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLPGQETFVKAQTETKVEPYKVHN 1104

Human  1106 PLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ 1153
            |:|||||||||||:|||||||.|||||||||||||||:|..|....||
  Rat  1105 PVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQDGPPQ 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGAM	NP_001139280.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	18..75		43/56 (77%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	76..135		48/58 (83%)
		vWA_integrins_alpha_subunit	149..324	CDD:238746	131/174 (75%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	339..390		42/50 (84%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	391..442		42/50 (84%)
		Int_alpha	453..>495	CDD:214549	32/41 (78%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	507..565		44/57 (77%)
		Int_alpha	517..563	CDD:214549	39/45 (87%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	570..630		44/59 (75%)
		Integrin_alpha2	616..979	CDD:462478	246/362 (68%)
		Integrin_alpha	1130..1144	CDD:459778	13/13 (100%)
		GFFKR motif	1132..1136		3/3 (100%)
Itgam	XP_006230276.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	131/174 (75%)
		Int_alpha	453..510	CDD:214549	46/56 (82%)
		Int_alpha	517..570	CDD:214549	42/52 (81%)
		Int_alpha	582..>606	CDD:214549	20/23 (87%)
		Integrin_alpha2	616..1032	CDD:462478	279/416 (67%)
		Integrin_alpha	1129..1141	CDD:459778	11/11 (100%)