DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITGAM and ina-1

DIOPT Version :10

Sequence 1:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens
Sequence 2:NP_499032.1 Gene:ina-1 / 176296 WormBaseID:WBGene00002081 Length:1139 Species:Caenorhabditis elegans


Alignment Length:1369 Identity:308/1369 - (22%)
Similarity:484/1369 - (35%) Gaps:489/1369 - (35%)


- Green bases have known domain annotations that are detailed below.


Human     7 LLTALTLCHGFNLDTENAMTFQENARG--FGQSVVQ-LQGSR--VVVGAPQ---EIVAANQRGSL 63
            ||..|:....||||. ||..::....|  ||.||.: .:|.:  :::|||:   ......:.|::
 Worm    10 LLLCLSCVKSFNLDV-NAPIYRYGPSGTNFGYSVAEHFKGDKPVMLIGAPRGESGQTGTERAGAM 73

Human    64 YQCD----YSTGS---CEPIRLQV---------PVEAVNMS---LGLS---LAAT-----TSPPQ 101
            |.||    |:.||   ||.:|.:.         |.|....:   ||.:   ||:|     |....
 Worm    74 YACDINTFYNGGSNHWCEQVRFEYENVEDYAKRPNETRGRTVHPLGKNDQLLASTIVSKGTKNGS 138

Human   102 LLACGPTV--HQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPH 164
            .|.|.|.:  |||.:   |.:|.|:...||||.|                               
 Worm   139 ALVCAPLIRYHQTAA---YPQGACYELESNLRLQ------------------------------- 169

Human   165 DFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTAT 229
                     ||                                                      
 Worm   170 ---------ST------------------------------------------------------ 171

Human   230 GIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSE 294
                       ....|:||                       :|..||..               
 Worm   172 -----------YATCAQKN-----------------------LPTTDRHN--------------- 187

Human   295 KSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAI 359
                                                                |:....|||||||
 Worm   188 ----------------------------------------------------EYGGCMEGFSAAI 200

Human   360 TSNGPLLSTVGSYDWAGGVFLYTSK--------EKSTFINMTRVDSDM-------NDAYLGYAAA 409
            |.:..:...:|:..|.||||...|.        ||.|   |.:.:.||       :| ||||:..
 Worm   201 TQDTIVTGLIGAVKWTGGVFAKKSSANIFDSVVEKYT---MNQPNGDMIRTRLVAHD-YLGYSVD 261

Human   410 I------ILRNRVQSLVLGAPRYQHIGLVAM--FRQNTG----MWESNANVKGTQIGAYFGASLC 462
            |      ....:..::|.||.||...|.|..  |.|::.    :.|....:.||.:|:.||.|:.
 Worm   262 IGRFGFWYEDGKPITVVSGATRYGEHGAVIFLPFIQDSSSKLTLNEDKFIINGTAMGSAFGYSIE 326

Human   463 SVDVDSNGSTDLVLIGAPHYY----EQTRGGQVSVCPLPRGQRARWQCDAVLYGEQ--GQP--WG 519
            .||::.:|..||: :|||..:    :...||.|.|......||.:.:...|.:..:  ..|  :.
 Worm   327 VVDLNGDGFDDLI-VGAPFEHRSGIDGNFGGIVYVYFSQGVQRKQHESHLVFHPPKILKNPDFYS 390

Human   520 RFGAALTVLGDVNGD--KLTDVAIGAPGEEDNRGAVYLFHGTSG-SGISPSHSQRIAGSKLSPRL 581
            :||.::|.||:|:||  ||.|.|:|||...|..||||::.||.. .......:|.|.|:.| |.|
 Worm   391 QFGLSITKLGNVDGDKSKLNDFAVGAPFAFDGAGAVYIYLGTKNIEKFRKKPAQVIKGNDL-PNL 454

Human   582 -----QYFGQSLSGGQDLTMDGLVDLTVG--AQGHVLLLRSQPVLRVKAIMEFNPREV------- 632
                 :.||.|||||.|:..:|..||.:|  ::..|.||||:||:.::...:...|.|       
 Worm   455 PPGGMRSFGFSLSGGSDMDENGYPDLLIGSPSKNFVALLRSRPVISIETKHKMEKRMVDIDKGVN 519

Human   633 ----ARNVFE------CNDQVVKGKE----AGEVRVC-LHVQKSTRDRLREGQIQSVVTYDLALD 682
                |:..|.      .:::..:|.|    :.:|.:| |.......|....|.|:...:::.:..
 Worm   520 CPRGAKTCFPLDMVIYVDEETKRGAELVDFSSDVFMCNLEAIPFRADTTARGFIEGSHSHNYSWP 584

Human   683 SGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSL------VGT 741
            .|..      :..:..|.||...|.:.::            :|.::|:..|...|:      |..
 Worm   585 CGSN------SHVQKRTYRQLIYLPVQES------------KDWITPLKFRFTVSIRNEKKPVQP 631

Human   742 PL-SAFGNLR--PVLAE-DAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVG-----G 797
            |. |...:|:  |||.: .|...|..  ||...||.|:.||.|||:..:|..:.....|     |
 Worm   632 PQGSQLVDLKHYPVLNKYGASYEFDV--PFNTLCGEDHTCQTDLSLKAAFKDIPLTSNGYVSNVG 694

Human   798 PREF-NVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEVSGALK 861
            .::: ::|.||.|..|.:|  |..|:    |.|.: ..|:..:.|.|.|:..|:.....|...|.
 Worm   695 EKDYLDLTFTVENKKEKAY--QANFY----LEYNE-EELELPQVQGSKRMIAETIGKNIVHLPLG 752

Human   862 STSCSINHPIFPEN--SEVTFNITFDV--DSKASLGNKLLLKANVTSENNMP----RTNKTEFQL 918
            :          |.|  |:..|.|.|.:  .....:|..|...|:|.|.:...    :.||.|.::
 Worm   753 N----------PMNGASKHQFTIQFKLTRGRTEGIGKALKFMAHVNSTSQETEEELKDNKWEAEV 807

Human   919 ELPVKYA---VYMV-----VTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQ---RSLPISLVF 972
            :: :|.|   :|.:     |...|.:.........|:...:::|.|.:.|.|.   |::...:.:
 Worm   808 QI-IKKAELEIYGISDPDRVFFGGKARAESELELEEDIGTMVRHNYTIINHGPWTVRNVEAHISW 871

Human   973 LVPVRL--------NQTVIWDRPQVT--FSENLSST--CHTKERLPSHSDFL--AELRKAPVVNC 1023
              |.:|        |...:.|.|.:|  |::..|..  |..|::.    :::  ||::.....:.
 Worm   872 --PYQLRSRFGRGKNALYLLDVPTITTEFTDGTSEVRKCFIKQQY----EYVNPAEIKLNTKYST 930

Human  1024 SIAVCQRI--------------QCD--------IPFFGIQEEFNA-TLKG---------NLS--- 1053
            ......|:              |.|        ||:|.....:|. .:||         :||   
 Worm   931 QETAPHRVEHRMKREIDEDEEEQSDDLGAVEENIPWFSTANFWNLFAIKGGDGRPREVKHLSCQD 995

Human  1054 -----------FDWYIKTSHNHLLIVSTAEILFN----------DSV-------FTLLPGQG--- 1087
                       ||:   ...|..:::.....|:|          :||       ..|...||   
 Worm   996 NTANCFTVICHFDF---IDANSAVVIDLRARLWNATFIEDYSDVESVKIRSFGKLQLDESQGIDD 1057

Human  1088 ------AFVRSQTETKVEPFEVP-----NPLP--LIVGSSVGGLLLLALITAALYKLGFFKRQYK 1139
                  |||    ||..:| :.|     .|:|  :.|.::|.|:|:|:||...|.|.|||||...
 Worm  1058 DPNNNAAFV----ETSADP-DRPTIGDSRPIPWWIYVIAAVIGVLILSLIIICLSKCGFFKRNRL 1117

Human  1140 DMMS 1143
            |..|
 Worm  1118 DQPS 1121

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 22/71 (31%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 23/80 (29%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 8/174 (5%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 19/58 (33%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 18/69 (26%)
Int_alpha 453..>495 CDD:214549 16/45 (36%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 24/64 (38%)
Int_alpha 517..563 CDD:214549 23/50 (46%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 25/66 (38%)
Integrin_alpha2 616..979 CDD:462478 89/427 (21%)
Integrin_alpha 1130..1144 CDD:459778 8/14 (57%)
GFFKR motif 1132..1136 3/3 (100%)
ina-1NP_499032.1 Int_alpha 34..>79 CDD:214549 13/44 (30%)
Int_alpha 317..>362 CDD:214549 16/45 (36%)
Int_alpha 388..434 CDD:214549 22/45 (49%)
Int_alpha 462..>502 CDD:214549 19/39 (49%)
Integrin_alpha2 496..1005 CDD:462478 110/552 (20%)

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