DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITGAM and pat-2

DIOPT Version :10

Sequence 1:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens
Sequence 2:NP_498948.1 Gene:pat-2 / 176240 WormBaseID:WBGene00003929 Length:1226 Species:Caenorhabditis elegans


Alignment Length:1444 Identity:274/1444 - (18%)
Similarity:460/1444 - (31%) Gaps:552/1444 - (38%)


- Green bases have known domain annotations that are detailed below.


Human     6 LLLTALTLCHG---FNLDTENAMTFQENARGFGQSV---VQLQGSRV-VVGAPQ------EIVAA 57
            |||..|.|..|   ||:||:|.:........||.|:   .:.:|..| |||||:      .:...
 Worm    12 LLLGLLGLLAGVATFNIDTKNVVVHHMAGNYFGYSLDFYHEQKGMPVLVVGAPEAESNNPNLAGI 76

Human    58 NQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGL 122
            .:.|::|.|..:..:|..:.:.                                      .:|| 
 Worm    77 RRPGAVYACSVNRATCREVHVD--------------------------------------KMKG- 102

Human   123 CFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLF 187
                  ||::                      ::|| .::|.:.:..:.|.:||....|..|.:.
 Worm   103 ------NLKK----------------------LNGS-HLVPIEEKSHQFFGATVRSNDKHDKIVV 138

Human   188 SLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKI 252
            ...:|:      :.:.:|:       :::|                 |...|...||        
 Worm   139 CAPKYT------YFYSKFE-------VIEP-----------------VGTCFYAENG-------- 165

Human   253 LVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNN 317
                     |.:...:.....|..|.|  |:.:|.|                             
 Worm   166 ---------FDNAEEFSSCKQEPARHG--RHRLGYG----------------------------- 190

Human   318 FEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAI----TSNGPLLSTVGSYDWAGGV 378
                                              |.|||||:    ..|...:...|.:.|.|.:
 Worm   191 ----------------------------------QCGFSAAVPGKKNQNRVFIGAPGVWYWQGAM 221

Human   379 FLYTSKEK----STFINMTRVDSDMNDAYLGYAAAI--ILRNRVQSLVLGAPRYQHI-GLVAMFR 436
            |....|.:    :|.......|.||    :||:.|.  ...:.:..:|.|.||...: |.:.::.
 Worm   222 FSQNIKNQTDRPNTEYGSKEYDHDM----MGYSTATGDFDGDGIDDIVAGVPRGNDLHGKLVLYT 282

Human   437 QNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQR 501
            ....|..:..:...||.|.|.|.|:...||:.:|..|::: |.|.|   |..|.|...   :.|.
 Worm   283 SKLKMMINLTDEVSTQHGQYCGGSVAVADVNKDGRDDIIM-GCPFY---TDYGSVKDA---KTQE 340

Human   502 ARWQCDA-----------VLYGEQ-----GQPWGRFGAALTVLGDVNGDKLTDVAIGAP-GEEDN 549
            .:.|.|.           .::|:|     ...|||||.|:...||:|.|...||.:||| ..::.
 Worm   341 RKPQYDVGKVIVMLQTAPGVFGKQIAVVGDDQWGRFGHAVAAAGDLNLDGYNDVIVGAPYAGKNK 405

Human   550 RGAVYLFHGTSGSGISPSHSQRIAGSKLS-PRLQYFGQSLSGGQDLTMDGLVDLTVGA--QGHVL 611
            :||||:.|| |..|:....:|:|.|:.:. ..::.||.||:|.:|:..:|:.|:.|||  .|:..
 Worm   406 QGAVYVIHG-SKDGVRELPTQKIEGANIGHGNIKSFGFSLTGNEDVDGNGMPDIAVGAWKSGNAA 469

Human   612 LLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVT 676
            :|.::||:.|....|.....::.....|:.....||:|     |.|:....:.. .:|...:.:.
 Worm   470 VLLTKPVVTVTGQTEPESALISVEDKNCDVDGKLGKQA-----CKHINTCFKYE-GKGDTPNDLE 528

Human   677 YDLA--LDSGRPHSRAVFNETKNSTRRQTQVLGLTQT-------------------CETLKLQLP 720
            :||.  ||...|..||.|.:....:.|..:|...::|                   |...:....
 Worm   529 FDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVAQGSKTRDHPSSIEQRVRLEKGRQKCFRHRFFAS 593

Human   721 NCIEDPVSPIVLRLNFSLVGTPLSAFGNLR-----PVLAEDAQRLFTALFPFEKNCGNDNICQDD 780
            :.::|.:|||...:|::.|.   |..|.||     |.:.......|........|||.|::|..|
 Worm   594 STMKDKLSPIHWSVNYTYVE---SKTGKLRGDKLEPAIDTTVPLSFQNKINIANNCGKDDLCVPD 655

Human   781 LSIT-------FSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQ 838
            |.:|       |...:.|..::       :.|||:|.|||||.|::.|..|....|..:.::...
 Worm   656 LKVTAVADREKFLLGTQDNTML-------INVTVQNGGEDSYETKLYFDVPQGFEYGGIESVGGD 713

Human   839 RSQRS---------------WRLACESA----SSTEVSGALKSTSCSINHPIFPENSEVTFNITF 884
            .|:.:               |..||:..    ::..||..::.|:.|...|:.|.:.....|.:.
 Worm   714 GSKSAPACSPTSDEPDSDGKWTFACDLGNPLPANKVVSSVVRVTASSDKPPLAPISINAHVNSSN 778

Human   885 DVDSKASLGNKLLLKANVTSENNMP---RTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASE 946
            |.::.....||:.....|..:|.:.   |:|..:....:..|             |:...|..:|
 Worm   779 DEEAHTVADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNK-------------TRVDAFDDNE 830

Human   947 NTSRVMQHQYQVSNLGQRSLPIS---------------LVFLV--PV------------------ 976
             ...|:.|.||:||.|...:..:               |::::  ||                  
 Worm   831 -IGPVVSHLYQISNRGPSEVDSATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVN 894

Human   977 ----RLNQTVIWDRPQVTFSEN------------------LSSTCHTKERLPSH----------- 1008
                |:....:...|.|..:.|                  ..||.|...:..:|           
 Worm   895 PLNLRITNEHVPTEPPVAKTPNEYSREEDDESYEDETTTQSQSTRHQSTQHQTHHQSGPVHVYEK 959

Human  1009 -------------------------------------------SDF------------------- 1011
                                                       .||                   
 Worm   960 DEEKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFEEEDDEDFDRAGSKRVKRNPTPKKKKK 1024

Human  1012 --------------LAELR---------------KAPV----VNCSIAVCQRIQCDIPFFGIQEE 1043
                          .::||               |.|:    |:|:...|..|:|||  :.::|:
 Worm  1025 GGEHRGEPRSDKARFSDLREAVKLSKEAGGVVDYKGPLSRASVDCNSLRCTHIECDI--YDLKED 1087

Human  1044 FNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPG---QGAFVRSQTETKVEPFEVPN 1105
                               ..:|:...:.:..|..|....||   ....:...|.||   :.:|:
 Worm  1088 -------------------EFVLVEIFSRLYTNTLVDEKNPGGDISSLALARVTSTK---YNLPH 1130

Human  1106 PLPLIVGSSVG-----------------------GLLLLALITAALYKLGFFKR----------- 1136
            ...||...|..                       ||.:|.|:...|::.|||||           
 Worm  1131 KPTLITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELR 1195

Human  1137 -------QYKDMMS 1143
                   ||.|..|
 Worm  1196 ADRQPNAQYADSQS 1209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 18/66 (27%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 4/58 (7%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 22/174 (13%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 13/58 (22%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 11/53 (21%)
Int_alpha 453..>495 CDD:214549 14/41 (34%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 26/74 (35%)
Int_alpha 517..563 CDD:214549 22/46 (48%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 20/62 (32%)
Integrin_alpha2 616..979 CDD:462478 91/456 (20%)
Integrin_alpha 1130..1144 CDD:459778 9/32 (28%)
GFFKR motif 1132..1136 3/3 (100%)
pat-2NP_498948.1 Int_alpha 39..98 CDD:214549 14/58 (24%)
Int_alpha 299..359 CDD:214549 17/66 (26%)
Int_alpha 372..427 CDD:214549 24/55 (44%)
Int_alpha 440..>462 CDD:214549 9/21 (43%)
Integrin_alpha2 474..936 CDD:462478 94/491 (19%)
Integrin_alpha 1178..1192 CDD:459778 5/13 (38%)

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